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• W2986248540 endingPage "83" @default.
• W2986248540 startingPage "76" @default.
• W2986248540 abstract "It has long been known that the electrophysiological effects of many cardioactive drugs strongly depend on the rate dependent frequency. This was recognized first for class I antiarrhythmic agents: their Vmax suppressive effect was attenuated at long cycle lengths. Later many Ca2+ channel blockers were also found to follow such kinetics. The explanation was provided by the modulated and the guarded receptor theories. Regarding the duration of cardiac action potentials (APD) an opposite frequency-dependence was observed, i.e. the drug-induced changes in APD were proportional with the cycle length of stimulation, therefore it was referred as “reverse rate-dependency”. The beat-to-beat, or short term variability of APD (SV) has been recognized as an important proarrhythmic mechanism, its magnitude can be used as an arrhythmia predictor. SV is modulated by several cardioactive agents, however, these drugs modify also APD itself. In order to clear the drug-specific effects on SV from the concomitant unspecific APD-change related ones, the term of “relative variability” was introduced. Relative variability is increased by ion channel blockers that decrease the negative feedback control of APD (i.e. blockers of ICa, IKr and IKs) and also by elevation of cytosolic Ca2+. Cardiac arrhythmias are also often categorized according to the characteristic heart rate (tachy- and bradyarrhythmias). Tachycardia is proarrhythmic primarily due to the concomitant Ca2+ overload causing delayed afterdepolarizations. Early afterdepolarizations (EADs) are complications of the bradycardic heart. What is common in the reverse rate-dependent nature of drug action on APD, increased SV and EAD incidence associated with bradycardia." @default.
• W2986248540 created "2019-11-22" @default.
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• W2986248540 date "2020-11-01" @default.
• W2986248540 modified "2023-10-15" @default.
• W2986248540 title "Implication of frequency-dependent protocols in antiarrhythmic and proarrhythmic drug testing" @default.
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• W2986248540 cites W1530248218 @default.
• W2986248540 cites W1575242179 @default.
• W2986248540 cites W1594424305 @default.
• W2986248540 cites W1967151871 @default.
• W2986248540 cites W1969629906 @default.
• W2986248540 cites W1969727832 @default.
• W2986248540 cites W1969813878 @default.
• W2986248540 cites W1975255825 @default.
• W2986248540 cites W1978834734 @default.
• W2986248540 cites W1998687211 @default.
• W2986248540 cites W2002374666 @default.
• W2986248540 cites W2002711428 @default.
• W2986248540 cites W2006529566 @default.
• W2986248540 cites W2007312710 @default.
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• W2986248540 cites W2021839839 @default.
• W2986248540 cites W2026630708 @default.
• W2986248540 cites W2027509335 @default.
• W2986248540 cites W2028167410 @default.
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• W2986248540 cites W2101483365 @default.
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• W2986248540 cites W2126112930 @default.
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• W2986248540 cites W2128728321 @default.
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• W2986248540 cites W2148835630 @default.
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• W2986248540 cites W2166325927 @default.
• W2986248540 cites W2167440643 @default.
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• W2986248540 doi "https://doi.org/10.1016/j.pbiomolbio.2019.11.001" @default.
• W2986248540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31726065" @default.
• W2986248540 hasPublicationYear "2020" @default.
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