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- W2986290296 abstract "Abstract Background Obesity and nonalcoholic steatohepatitis (NASH) are well-known risk factors of hepatocellular carcinoma (HCC). The lipid-rich environment enhances the proliferation and metastasis abilities of tumor cells. Previous studies showed the effect of the ubiquitin–proteasome system (UPS) on tumor cell proliferation. However, the underlying mechanism of UPS in regulating the proliferation of lipid-rich tumor cells is not totally clear. Results Here, we identify two proteasome 26S subunits, non-ATPase 1 and 2 ( PSMD1 and PSMD2 ), which regulate HepG2 cells proliferation via modulating cellular lipid metabolism. Briefly, the knockdown of PSMD1 and/or PSMD2 decreases the formation of cellular lipid droplets, the provider of the energy and membrane components for tumor cell proliferation. Mechanically, PSMD1 and PSMD2 regulate the expression of genes related to de novo lipid synthesis via p38-JNK and AKT signaling. Moreover, the high expression of PSMD1 and PSMD2 is significantly correlated with poor prognosis of HCC. Conclusion We demonstrate that PSMD1 and PSMD2 promote the proliferation of HepG2 cells via facilitating cellular lipid droplet accumulation. This study provides a potential therapeutic strategy for the treatment of lipid-rich tumors." @default.
- W2986290296 created "2019-11-22" @default.
- W2986290296 creator A5033577646 @default.
- W2986290296 creator A5043657110 @default.
- W2986290296 creator A5076167118 @default.
- W2986290296 creator A5081851613 @default.
- W2986290296 date "2019-11-08" @default.
- W2986290296 modified "2023-10-14" @default.
- W2986290296 title "PSMD1 and PSMD2 regulate HepG2 cell proliferation and apoptosis via modulating cellular lipid droplet metabolism" @default.
- W2986290296 cites W1485543117 @default.
- W2986290296 cites W1485927957 @default.
- W2986290296 cites W1516920003 @default.
- W2986290296 cites W1605704109 @default.
- W2986290296 cites W1757407923 @default.
- W2986290296 cites W1908445283 @default.
- W2986290296 cites W1970826261 @default.
- W2986290296 cites W1972893985 @default.
- W2986290296 cites W1976806248 @default.
- W2986290296 cites W1982654262 @default.
- W2986290296 cites W1988117658 @default.
- W2986290296 cites W1989105287 @default.
- W2986290296 cites W1991841644 @default.
- W2986290296 cites W1991930087 @default.
- W2986290296 cites W1992174702 @default.
- W2986290296 cites W1992689141 @default.
- W2986290296 cites W1995646666 @default.
- W2986290296 cites W1996575904 @default.
- W2986290296 cites W2003924932 @default.
- W2986290296 cites W2005062144 @default.
- W2986290296 cites W2015975538 @default.
- W2986290296 cites W2017613824 @default.
- W2986290296 cites W2020031294 @default.
- W2986290296 cites W2022650450 @default.
- W2986290296 cites W2022733347 @default.
- W2986290296 cites W2024103922 @default.
- W2986290296 cites W2026788714 @default.
- W2986290296 cites W2027037928 @default.
- W2986290296 cites W2033715459 @default.
- W2986290296 cites W2034781186 @default.
- W2986290296 cites W2041237929 @default.
- W2986290296 cites W2043234667 @default.
- W2986290296 cites W2055811314 @default.
- W2986290296 cites W2059515537 @default.
- W2986290296 cites W2060608010 @default.
- W2986290296 cites W2060660978 @default.
- W2986290296 cites W2060905615 @default.
- W2986290296 cites W2061063821 @default.
- W2986290296 cites W2061795728 @default.
- W2986290296 cites W2062546298 @default.
- W2986290296 cites W2067653691 @default.
- W2986290296 cites W2070219820 @default.
- W2986290296 cites W2071191421 @default.
- W2986290296 cites W2073692026 @default.
- W2986290296 cites W2073858365 @default.
- W2986290296 cites W2076425088 @default.
- W2986290296 cites W2085390667 @default.
- W2986290296 cites W2086039159 @default.
- W2986290296 cites W2086500674 @default.
- W2986290296 cites W2086589308 @default.
- W2986290296 cites W2090914127 @default.
- W2986290296 cites W2100253993 @default.
- W2986290296 cites W2102714295 @default.
- W2986290296 cites W2105706568 @default.
- W2986290296 cites W2110096065 @default.
- W2986290296 cites W2132218352 @default.
- W2986290296 cites W2136187443 @default.
- W2986290296 cites W2138090713 @default.
- W2986290296 cites W2147347287 @default.
- W2986290296 cites W2147963733 @default.
- W2986290296 cites W2150494760 @default.
- W2986290296 cites W2151458137 @default.
- W2986290296 cites W2152794772 @default.
- W2986290296 cites W2161002942 @default.
- W2986290296 cites W2162571565 @default.
- W2986290296 cites W2165424687 @default.
- W2986290296 cites W2166064199 @default.
- W2986290296 cites W2167681464 @default.
- W2986290296 cites W2170731941 @default.
- W2986290296 cites W2178503716 @default.
- W2986290296 cites W2188093405 @default.
- W2986290296 cites W2188375152 @default.
- W2986290296 cites W2257489030 @default.
- W2986290296 cites W2277539891 @default.
- W2986290296 cites W2304335366 @default.
- W2986290296 cites W2461005767 @default.
- W2986290296 cites W2509246155 @default.
- W2986290296 cites W2521650041 @default.
- W2986290296 cites W2559506169 @default.
- W2986290296 cites W2591921185 @default.
- W2986290296 cites W2605610684 @default.
- W2986290296 cites W2607129810 @default.
- W2986290296 cites W2739293386 @default.
- W2986290296 cites W2743327074 @default.
- W2986290296 cites W2743619083 @default.
- W2986290296 cites W2745050039 @default.
- W2986290296 cites W2756293698 @default.
- W2986290296 cites W2772305187 @default.
- W2986290296 cites W2803384724 @default.
- W2986290296 cites W2808186933 @default.
- W2986290296 cites W3141734911 @default.