FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2986341714> ?p ?o ?g. }

• W2986341714 endingPage "335" @default.
• W2986341714 startingPage "335" @default.
• W2986341714 abstract "The objective of this study was to investigate the dose-dependent effect of 1α,25-(OH)2VD3 (Vit D3) on invitro proliferation of goat luteinised granulosa cells (LGCs) and to determine the underlying mechanisms of its action by overexpressing and silencing vitamin D receptor (VDR) in LGCs. Results showed that VDR was prominently localised in GCs and theca cells (TCs) and its expression increased with follicle diameter, but was lower in atretic follicles than in healthy follicles. The proliferation rate of LGCs was significantly higher in the Vit D3-treated groups than in the control group, with the highest proliferation rate observed in the 10nM group; this was accompanied by changes in the expression of cell cycle-related genes. These data indicate that Vit D3 affects LGC proliferation in a dose-dependent manner. Contrary to the VDR knockdown effects, its overexpression upregulated and downregulated cell cycle- and apoptosis-related genes respectively; moreover, supplementation with 10nM of Vit D3 significantly enhanced these effects. These results suggest that changes in VDR expression patterns in LGCs may be associated with follicular development by regulation of cell proliferation and apoptosis. These findings will enhance the understanding of the roles of Vit D3 and VDR in goat ovarian follicular development." @default.
• W2986341714 created "2019-11-22" @default.
• W2986341714 creator A5005678403 @default.
• W2986341714 creator A5036653885 @default.
• W2986341714 creator A5047953619 @default.
• W2986341714 creator A5065058975 @default.
• W2986341714 creator A5066052268 @default.
• W2986341714 creator A5075195393 @default.
• W2986341714 creator A5087839934 @default.
• W2986341714 date "2020-01-01" @default.
• W2986341714 modified "2023-09-26" @default.
• W2986341714 title "Roles of vitamin D and its receptor in the proliferation and apoptosis of luteinised granulosa cells in the goat" @default.
• W2986341714 cites W1569138725 @default.
• W2986341714 cites W1814451158 @default.
• W2986341714 cites W1964335024 @default.
• W2986341714 cites W1967211197 @default.
• W2986341714 cites W1968057472 @default.
• W2986341714 cites W1973859913 @default.
• W2986341714 cites W1981755240 @default.
• W2986341714 cites W1986821460 @default.
• W2986341714 cites W1989693389 @default.
• W2986341714 cites W1990454289 @default.
• W2986341714 cites W1990505546 @default.
• W2986341714 cites W2012543499 @default.
• W2986341714 cites W2013300858 @default.
• W2986341714 cites W2017019792 @default.
• W2986341714 cites W2023683218 @default.
• W2986341714 cites W2038138833 @default.
• W2986341714 cites W2041290320 @default.
• W2986341714 cites W2052153800 @default.
• W2986341714 cites W2053516868 @default.
• W2986341714 cites W2059147235 @default.
• W2986341714 cites W2063667483 @default.
• W2986341714 cites W2066362146 @default.
• W2986341714 cites W2067938814 @default.
• W2986341714 cites W2073427932 @default.
• W2986341714 cites W2075144393 @default.
• W2986341714 cites W2082177709 @default.
• W2986341714 cites W2097191932 @default.
• W2986341714 cites W2105346319 @default.
• W2986341714 cites W2122187541 @default.
• W2986341714 cites W2127675927 @default.
• W2986341714 cites W2143286740 @default.
• W2986341714 cites W2148321928 @default.
• W2986341714 cites W2150903452 @default.
• W2986341714 cites W2155746549 @default.
• W2986341714 cites W2163649651 @default.
• W2986341714 cites W2165975054 @default.
• W2986341714 cites W2327878033 @default.
• W2986341714 cites W2345030075 @default.
• W2986341714 cites W2526188163 @default.
• W2986341714 cites W2557260628 @default.
• W2986341714 cites W2575955237 @default.
• W2986341714 cites W2580547060 @default.
• W2986341714 cites W2590790840 @default.
• W2986341714 cites W2594384223 @default.
• W2986341714 cites W2598988730 @default.
• W2986341714 cites W2744949294 @default.
• W2986341714 cites W2757337574 @default.
• W2986341714 cites W2767407320 @default.
• W2986341714 cites W2768366646 @default.
• W2986341714 cites W2768544209 @default.
• W2986341714 cites W2770457711 @default.
• W2986341714 cites W2773928224 @default.
• W2986341714 cites W2791700822 @default.
• W2986341714 cites W2792082196 @default.
• W2986341714 cites W2792706623 @default.
• W2986341714 cites W2793676847 @default.
• W2986341714 cites W2803566043 @default.
• W2986341714 cites W2805842931 @default.
• W2986341714 cites W2898007959 @default.
• W2986341714 cites W2899226093 @default.
• W2986341714 cites W2901217872 @default.
• W2986341714 cites W3022293799 @default.
• W2986341714 doi "https://doi.org/10.1071/rd18442" @default.
• W2986341714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31708013" @default.
• W2986341714 hasPublicationYear "2020" @default.
• W2986341714 type Work @default.
• W2986341714 sameAs 2986341714 @default.
• W2986341714 citedByCount "9" @default.
• W2986341714 countsByYear W29863417142020 @default.
• W2986341714 countsByYear W29863417142021 @default.
• W2986341714 countsByYear W29863417142022 @default.
• W2986341714 countsByYear W29863417142023 @default.
• W2986341714 crossrefType "journal-article" @default.
• W2986341714 hasAuthorship W2986341714A5005678403 @default.
• W2986341714 hasAuthorship W2986341714A5036653885 @default.
• W2986341714 hasAuthorship W2986341714A5047953619 @default.
• W2986341714 hasAuthorship W2986341714A5065058975 @default.
• W2986341714 hasAuthorship W2986341714A5066052268 @default.
• W2986341714 hasAuthorship W2986341714A5075195393 @default.
• W2986341714 hasAuthorship W2986341714A5087839934 @default.
• W2986341714 hasConcept C104317684 @default.
• W2986341714 hasConcept C124490489 @default.
• W2986341714 hasConcept C126322002 @default.
• W2986341714 hasConcept C127561419 @default.
• W2986341714 hasConcept C134018914 @default.
• W2986341714 hasConcept C16685009 @default.

• next