FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2986343422> ?p ?o ?g. }

• W2986343422 abstract "Abstract The plant immune system relies on both cell-surface and intracellular NLR (nucleotide-binding, leucine-rich repeat) receptors. NLRs respond to pathogen effectors and activate effector-triggered immunity: a cocktail of responses, often accompanied by cell death, resulting in resistance. RPW8 encodes an unusual non-NLR Resistance (R) protein and confers broad-spectrum powdery mildew resistance. It requires genetic components also required by some NLRs, resembles the HeLo-containing protein MLKL (necroptosis executor in animals) and HET-S (cell death executor in fungi) and is targeted to the extra-haustorial membrane during powdery mildew infection by its N-terminal non-cleaved signal anchor domain. RPW8 displays extensive recent duplication events in Arabidopsis and certain alleles can induce oligomerisation-dependent activation of the NLR RPP7. All these features enabled us to formulate hypotheses for RPW8 function: (1) RPW8 could be a cell death executor for defence against pathogens. (2) RPW8 could be a decoy for effector targets. To test these hypotheses, we generated a quadruple knock-out mutant of the four RPW8 -homologous copies in Arabidopsis Col-0, using CRISPR. The mutant still displays cell death upon activation of four well-characterised NLRs. However, it is partially impaired in powdery mildew resistance and also in bacterial resistance. Interestingly Col-0_ rpw8 is delayed in flowering transition. In conclusion, RPW8 plays a broad role in immunity and plant development, beyond resistance to powdery mildew. There is no evidence that it is involved in executing ETI-associated cell death." @default.
• W2986343422 created "2019-11-22" @default.
• W2986343422 creator A5002834524 @default.
• W2986343422 creator A5020852320 @default.
• W2986343422 creator A5034927034 @default.
• W2986343422 creator A5083911307 @default.
• W2986343422 date "2019-11-12" @default.
• W2986343422 modified "2023-09-27" @default.
• W2986343422 title "An <i>rpw8</i> quadruple mutant of Arabidopsis Col-0 is partially compromised in bacterial and fungal resistance" @default.
• W2986343422 cites W1599420452 @default.
• W2986343422 cites W1887883084 @default.
• W2986343422 cites W1963837218 @default.
• W2986343422 cites W1970893992 @default.
• W2986343422 cites W1975359899 @default.
• W2986343422 cites W1988178270 @default.
• W2986343422 cites W1993613360 @default.
• W2986343422 cites W1996573117 @default.
• W2986343422 cites W2010174706 @default.
• W2986343422 cites W2045554913 @default.
• W2986343422 cites W2050823608 @default.
• W2986343422 cites W2051410022 @default.
• W2986343422 cites W2051866530 @default.
• W2986343422 cites W2057055150 @default.
• W2986343422 cites W2073936714 @default.
• W2986343422 cites W2076770517 @default.
• W2986343422 cites W2092388446 @default.
• W2986343422 cites W2098439072 @default.
• W2986343422 cites W2107277218 @default.
• W2986343422 cites W2113030015 @default.
• W2986343422 cites W2123426755 @default.
• W2986343422 cites W2132888578 @default.
• W2986343422 cites W2135198664 @default.
• W2986343422 cites W2135575280 @default.
• W2986343422 cites W2138826207 @default.
• W2986343422 cites W2150010045 @default.
• W2986343422 cites W2160253662 @default.
• W2986343422 cites W2160864234 @default.
• W2986343422 cites W2162515800 @default.
• W2986343422 cites W2165462764 @default.
• W2986343422 cites W2171673901 @default.
• W2986343422 cites W2229860479 @default.
• W2986343422 cites W2287080039 @default.
• W2986343422 cites W2479540212 @default.
• W2986343422 cites W2509994829 @default.
• W2986343422 cites W2526924313 @default.
• W2986343422 cites W2555833859 @default.
• W2986343422 cites W2611732598 @default.
• W2986343422 cites W2622162736 @default.
• W2986343422 cites W2674992612 @default.
• W2986343422 cites W2761688050 @default.
• W2986343422 cites W2769076637 @default.
• W2986343422 cites W2785524837 @default.
• W2986343422 cites W2899395786 @default.
• W2986343422 cites W2906030297 @default.
• W2986343422 cites W2906522235 @default.
• W2986343422 cites W2914397585 @default.
• W2986343422 cites W2920875031 @default.
• W2986343422 cites W2924139971 @default.
• W2986343422 cites W2925693760 @default.
• W2986343422 cites W2927068340 @default.
• W2986343422 cites W2943758969 @default.
• W2986343422 cites W2947946230 @default.
• W2986343422 cites W2949951347 @default.
• W2986343422 cites W2952594972 @default.
• W2986343422 cites W2969268623 @default.
• W2986343422 cites W2969680514 @default.
• W2986343422 cites W2969924257 @default.
• W2986343422 cites W4243039810 @default.
• W2986343422 doi "https://doi.org/10.1101/839308" @default.
• W2986343422 hasPublicationYear "2019" @default.
• W2986343422 type Work @default.
• W2986343422 sameAs 2986343422 @default.
• W2986343422 citedByCount "2" @default.
• W2986343422 countsByYear W29863434222020 @default.
• W2986343422 countsByYear W29863434222022 @default.
• W2986343422 crossrefType "posted-content" @default.
• W2986343422 hasAuthorship W2986343422A5002834524 @default.
• W2986343422 hasAuthorship W2986343422A5020852320 @default.
• W2986343422 hasAuthorship W2986343422A5034927034 @default.
• W2986343422 hasAuthorship W2986343422A5083911307 @default.
• W2986343422 hasBestOaLocation W29863434221 @default.
• W2986343422 hasConcept C104317684 @default.
• W2986343422 hasConcept C143065580 @default.
• W2986343422 hasConcept C17744445 @default.
• W2986343422 hasConcept C180591056 @default.
• W2986343422 hasConcept C199539241 @default.
• W2986343422 hasConcept C2776460866 @default.
• W2986343422 hasConcept C2779336322 @default.
• W2986343422 hasConcept C2779491563 @default.
• W2986343422 hasConcept C2780381237 @default.
• W2986343422 hasConcept C51785407 @default.
• W2986343422 hasConcept C54355233 @default.
• W2986343422 hasConcept C59822182 @default.
• W2986343422 hasConcept C86803240 @default.
• W2986343422 hasConcept C95444343 @default.
• W2986343422 hasConceptScore W2986343422C104317684 @default.
• W2986343422 hasConceptScore W2986343422C143065580 @default.
• W2986343422 hasConceptScore W2986343422C17744445 @default.
• W2986343422 hasConceptScore W2986343422C180591056 @default.
• W2986343422 hasConceptScore W2986343422C199539241 @default.

• next