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- W2986437218 abstract "Abstract Implantation of biodegradable wafers near the brain surgery site to deliver anti-cancer agents which target residual tumor cells by bypassing the blood-brain barrier has been a promising method for brain tumor treatment. However, further improvement in the prognosis is still necessary. We herein present novel materials and device technologies for drug delivery to brain tumors, i.e., a flexible, sticky, and biodegradable drug-loaded patch integrated with wireless electronics for controlled intracranial drug delivery through mild-thermic actuation. The flexible and bifacially-designed sticky/hydrophobic device allows conformal adhesion on the brain surgery site and provides spatially-controlled and temporarily-extended drug delivery to brain tumors while minimizing unintended drug leakage to the cerebrospinal fluid. Biodegradation of the entire device minimizes potential neurological side-effects. Application of the device to the mouse model confirms tumor volume suppression and improved survival rate. Demonstration in a large animal model (canine model) exhibited its potential for human application." @default.
- W2986437218 created "2019-11-22" @default.
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- W2986437218 date "2019-11-15" @default.
- W2986437218 modified "2023-10-18" @default.
- W2986437218 title "Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors" @default.
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- W2986437218 doi "https://doi.org/10.1038/s41467-019-13198-y" @default.
- W2986437218 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6858362" @default.
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