FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2986474427> ?p ?o ?g. }

• W2986474427 endingPage "vi137" @default.
• W2986474427 startingPage "vi137" @default.
• W2986474427 abstract "Abstract PURPOSE Glioblastomas (GBM) are the most common primary brain tumour recurring in most patients despite maximal management. Patient selection for appropriate treatment modality remains challenging resulting in heterogeneity in management. We examined the patterns of failure and developed a scoring system for patient stratification to optimise clinical decision making. METHODS 822 adults (BC Cancer Agency registry) diagnosed 2005–2015 age ≥60 with histologically confirmed GBM ICD-O-3 codes (9440/3, 9441/3, 9442/3) were reviewed. Univariate and Kaplan-Meier analysis were performed. Performance status (PS), age and resection status were assigned a score, cummulative maximal (favorable) score of 10 and minimum (unfavorable) score of 3. Patterns of failure were further analysed in the subset of patients with radiographic follow-up. RESULTS PS score of 3(KPS >80, ECOG 0/1), 2 (KPS 60–70, ECOG 2), 1 (KPS < 60, ECOG 3/4) (median OS 11, 6, 3 months respectively), age score and resection status were prognostic for OS with PS resulting in the most significant curve separation (p< 0.0001). Biopsy as compared to STR/GTR resulted in poorer OS in patients over 70 (age score 1/2) but had less impact in patients younger than 70 (age scores 3/4). The median OS for cumulative scores of 9/10 (123 patients), 7/8 (286 patients), 5/6 (313 patients), and 3/4 (55 patients) were 14, 8, 4 and 2 months respectively (p< 0.0001) allowing for stratification into 4 prognostic groups. 133 patients had >3 MRIs following diagnosis allowing for clinical and radiographic analysis of progression. Clinical/radiographic progression occurred within 3 months (29%/45%), 6 months (50%/66%), 9 months (70%/81%). Progression type (radiographic, clinical, both was not associated with OS. CONCLUSION Our novel prognostic scoring system is effective in achieving patient stratification and may guide clinical decision making. Early radiographic progression appears to precede clinical deterioration and may represent true progression in the elderly." @default.
• W2986474427 created "2019-11-22" @default.
• W2986474427 creator A5006218720 @default.
• W2986474427 creator A5036844482 @default.
• W2986474427 creator A5089466497 @default.
• W2986474427 date "2019-11-01" @default.
• W2986474427 modified "2023-10-03" @default.
• W2986474427 title "INNV-34. PATTERNS OF FAILURE AND DEVELOPMENT OF A NOVEL PROGNOSTIC SCORING SYSTEM IN ELDERLY PATIENTS WITH GLIOBLASTOMA – FOLLOW UP ON 10 YEAR ANALYSIS OF THE BC CANCER AGENCY POPULATION" @default.
• W2986474427 doi "https://doi.org/10.1093/neuonc/noz175.575" @default.
• W2986474427 hasPublicationYear "2019" @default.
• W2986474427 type Work @default.
• W2986474427 sameAs 2986474427 @default.
• W2986474427 citedByCount "2" @default.
• W2986474427 countsByYear W29864744272022 @default.
• W2986474427 countsByYear W29864744272023 @default.
• W2986474427 crossrefType "journal-article" @default.
• W2986474427 hasAuthorship W2986474427A5006218720 @default.
• W2986474427 hasAuthorship W2986474427A5036844482 @default.
• W2986474427 hasAuthorship W2986474427A5089466497 @default.
• W2986474427 hasBestOaLocation W29864744271 @default.
• W2986474427 hasConcept C121608353 @default.
• W2986474427 hasConcept C126322002 @default.
• W2986474427 hasConcept C141071460 @default.
• W2986474427 hasConcept C144301174 @default.
• W2986474427 hasConcept C2776194525 @default.
• W2986474427 hasConcept C2776907518 @default.
• W2986474427 hasConcept C2908647359 @default.
• W2986474427 hasConcept C38180746 @default.
• W2986474427 hasConcept C502942594 @default.
• W2986474427 hasConcept C71924100 @default.
• W2986474427 hasConcept C99454951 @default.
• W2986474427 hasConceptScore W2986474427C121608353 @default.
• W2986474427 hasConceptScore W2986474427C126322002 @default.
• W2986474427 hasConceptScore W2986474427C141071460 @default.
• W2986474427 hasConceptScore W2986474427C144301174 @default.
• W2986474427 hasConceptScore W2986474427C2776194525 @default.
• W2986474427 hasConceptScore W2986474427C2776907518 @default.
• W2986474427 hasConceptScore W2986474427C2908647359 @default.
• W2986474427 hasConceptScore W2986474427C38180746 @default.
• W2986474427 hasConceptScore W2986474427C502942594 @default.
• W2986474427 hasConceptScore W2986474427C71924100 @default.
• W2986474427 hasConceptScore W2986474427C99454951 @default.
• W2986474427 hasIssue "Supplement_6" @default.
• W2986474427 hasLocation W29864744271 @default.
• W2986474427 hasLocation W29864744272 @default.
• W2986474427 hasOpenAccess W2986474427 @default.
• W2986474427 hasPrimaryLocation W29864744271 @default.
• W2986474427 hasRelatedWork W2000431044 @default.
• W2986474427 hasRelatedWork W2011936303 @default.
• W2986474427 hasRelatedWork W2030729277 @default.
• W2986474427 hasRelatedWork W2044980821 @default.
• W2986474427 hasRelatedWork W2130254160 @default.
• W2986474427 hasRelatedWork W2171699024 @default.
• W2986474427 hasRelatedWork W2414949291 @default.
• W2986474427 hasRelatedWork W2418168045 @default.
• W2986474427 hasRelatedWork W2606371609 @default.
• W2986474427 hasRelatedWork W3030061193 @default.
• W2986474427 hasVolume "21" @default.
• W2986474427 isParatext "false" @default.
• W2986474427 isRetracted "false" @default.
• W2986474427 magId "2986474427" @default.
• W2986474427 workType "article" @default.