Matches in SemOpenAlex for { <https://semopenalex.org/work/W2986500190> ?p ?o ?g. }
- W2986500190 abstract "Plants make chemical compounds to protect themselves. For example, chili peppers produce the spicy compound capsaicin to inhibit pathogen damage and animal feeding. In humans, capsaicin binds to a membrane channel protein, creating the sensation of heat, while in microbes, capsaicin limits energy production by binding respiratory enzymes. However, some data suggest that capsaicin also disrupts membranes. Here, we studied fungal pathogens ( Alternaria , Colletotrichum , Fusarium , and Phomopsis ) isolated from a wild chili pepper, Capsicum chacoense . By measuring growth rates in the presence of antibiotics with known respiratory targets, we inferred that wild-plant pathogens might be rich in alternative respiratory enzymes. A zone of clearance around the colonies, as well as liquid chromatography-mass spectrometry data, further indicated that these fungi can break down capsaicin. Finally, the total inhibitory effect of capsaicin was not fully explained by its effect on respiratory enzymes. Our findings lend credence to studies proposing that capsaicin may disrupt cell membranes, with implications for microbiology, as well as human health." @default.
- W2986500190 created "2019-11-22" @default.
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- W2986500190 date "2020-01-21" @default.
- W2986500190 modified "2023-09-29" @default.
- W2986500190 title "Fungal Seed Pathogens of Wild Chili Peppers Possess Multiple Mechanisms To Tolerate Capsaicinoids" @default.
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- W2986500190 doi "https://doi.org/10.1128/aem.01697-19" @default.
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