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• W2986549885 startingPage "53" @default.
• W2986549885 abstract "Aim: This study profiled differentially expressed long noncoding RNAs (lncRNAs) in lung squamous cell carcinoma (LSCC) to predict LSCC overall survival (OS) using The Cancer Genome Atlas data. Materials & methods: The RNA-seq and clinical dataset of 475 LSCC patients was retrieved from The Cancer Genome Atlas database and statistically analyzed. Results: There were 67 upregulated and 32 downregulated lncRNAs in LSCCs and 12 lncRNAs associated with OS. The seven-lncRNA signature was associated with poor OS and RP11-150O12.6 and CTA-384D8.35 were associated with better OS (p < 0.001). The seven lncRNAs-mRNA interaction network analysis showed their association with 187 protein-coding genes for cancer development, cell migration, adhesion, proliferation, apoptosis, angiogenesis and the MAPK signaling pathways. Conclusion: This seven-lncRNA signature is useful to predict LSCC OS." @default.
• W2986549885 created "2019-11-22" @default.
• W2986549885 creator A5004636265 @default.
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• W2986549885 date "2020-01-01" @default.
• W2986549885 modified "2023-09-23" @default.
• W2986549885 title "A seven long-noncoding RNA signature predicts prognosis of lung squamous cell carcinoma" @default.
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• W2986549885 doi "https://doi.org/10.2217/bmm-2019-0282" @default.
• W2986549885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31729251" @default.
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