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• W2986564487 endingPage "117529" @default.
• W2986564487 startingPage "117529" @default.
• W2986564487 abstract "Abnormal expression of MicroRNA-21 (miRNA-21) is considered to be a reliable biomarker for the early diagnosis of cancer. In this work, a novel paper based biosensor was fabricated to detect sub-micro molar concentrations of miRNA-21 based on peroxidase mimetic activity of DNA-templated Ag/Pt nanoclusters (DNA-Ag/Pt NCs), which could catalyze the reaction of hydrogen peroxide and 3,3',5,5' tetramethylbenzidine (TMB), to produce a blue color. The Mechanism of reaction was based on the inhibition effect of miRNA-21 on peroxidase-like activity of nanosensor which resulted to quantitative determination of miRNA-21 concentration. It was found that miRNA-21 could be linearly detected in the range from 1-700 pM (A652 = 0.16x-0.96, R2 = 0.99; x = -log [miRNA-21]) with a detection limit of 0.6 pM. Moreover, a paper assay was carried out on a Y-shaped paper-based microfluidic device in order to use the distinctive features of micro-channels such as short response time, very low reagent volume, low fabrication cost, etc. After performing paper based assay, a good linear range was observed between 10-1000 pM (y = 0.06x+147.48, R2 = 0.99; x = [miRNA-21]) with detection limit of 4.1 pM. The practical application of proposed method for detection of miRNA-21 in real sample was assayed in the human urine sample and indicated the colorimetric method had acceptable accuracy." @default.
• W2986564487 created "2019-11-22" @default.
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• W2986564487 date "2020-02-01" @default.
• W2986564487 modified "2023-10-15" @default.
• W2986564487 title "Paper based colorimetric detection of miRNA-21 using Ag/Pt nanoclusters" @default.
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• W2986564487 doi "https://doi.org/10.1016/j.saa.2019.117529" @default.
• W2986564487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31703998" @default.
• W2986564487 hasPublicationYear "2020" @default.
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