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• W2986573745 abstract "<h3>BACKGROUND</h3> This study was designed to test the association of <i>Chlamydia pneumoniae </i>infection with asthma in a multiracial population, after adjustments for several potential confounding variables. <h3>METHODS</h3> Antibodies to<i> C pneumoniae</i>were measured by microimmunofluorescence in 123 patients with acute asthma, 1518 control subjects admitted to the same hospital with various non-cardiovascular, non-pulmonary disorders, and 46 patients with severe chronic asthma, including some with “brittle” asthma. Acute infection or reinfection was defined by titres of IgG of ⩾512 or IgM ⩾8 or a fourfold rise in IgG, and previous infection by IgG 64–256 or IgA ⩾8. Logistic regression was used to control for likely confounders, including ethnic origin, age, sex, smoking habit, steroid medication, diabetes mellitus and social deprivation, on antibody levels. <h3>RESULTS</h3> Antibody titres consistent with acute<i>C pneumoniae </i>infection were found in 5.7% of patients with acute asthma and 5.7% of control patients, while 14.6% of patients with acute asthma and 12.7% of control patients had titres suggesting previous infection. These two groups did not differ significantly. However, titres suggesting previous infection were found in 34.8% of patients with severe chronic asthma: the difference between this group and the control group was statistically significant with an adjusted odds ratio of 3.99 (95% confidence interval 1.60 to 9.97). <h3>CONCLUSIONS</h3> These data raise important questions about the previously demonstrated association of <i>C pneumoniae</i> infection with asthma, and suggest that future studies of this association should give particular attention to the presence or absence of a history of severe chronic asthma." @default.
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• W2986573745 date "1998-04-01" @default.
• W2986573745 modified "2023-10-10" @default.
• W2986573745 title "Chlamydia pneumoniae and asthma" @default.
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• W2986573745 doi "https://doi.org/10.1136/thx.53.4.254" @default.
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