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• W2986644114 endingPage "104600" @default.
• W2986644114 startingPage "104600" @default.
• W2986644114 abstract "To assess whether subgingival irrigation with 0.12 % or 0.2 % chlorhexidine (CHX) immediately after scaling and root planing (SRP) enhances periodontal tissue repair compared to irrigation with saline solution (control). Periodontitis was ligature-induced in rat molars for 7 days. Animals were distributed into three groups: 1) SRP group, SRP and irrigation with 0.9 % saline (n = 30); 2) SRP + 0.12 % CHX group, SRP and irrigation with 0.12 % CHX (n = 30); 3) SRP + 0.2 % CHX group, SRP and irrigation with 0.2 % CHX (n = 30). Animals were killed at 7, 15, and 30 days after treatment. Furcation region was histometrically analyzed to determine the bone area. Immunohistochemical reactions were performed for receptor activator of nuclear factor-kB ligand (RANKL), osteoprotegerin (OPG) and tartrate-resistant acid phosphatase (TRAP). Both chlorhexidine groups presented less inflammation and improved tissue repair along the entire experiment when compared with the SRP group. In the histometric analysis at 7, 15 and 30 days, SRP group (4.58 ± 2.51 mm2, 4.21 ± 1.25 mm2, 3.49 ± 1.48 mm2), showed statistically less bone area than groups SRP + 0.12 % CHX (1.86 ± 1.11 mm2; 0.79 ± 0.27 mm2; 0.34 ± 0.14 mm2) and SRP + 0.2 % CHX (1.14 ± 0.51 mm2; 0.98 ± 0.40 mm2; 0.41 ± 0.21 mm2). Both chlorhexidine concentrations modulated the expression of TRAP, RANKL and OPG. Subgingival irrigation with chlorhexidine contributed for a quicker shift from a proinflammatory destructive profile to healing of periodontal tissues." @default.
• W2986644114 created "2019-11-22" @default.
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• W2986644114 date "2020-02-01" @default.
• W2986644114 modified "2023-10-14" @default.
• W2986644114 title "Treatment of experimental periodontitis with chlorhexidine as adjuvant to scaling and root planing" @default.
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• W2986644114 doi "https://doi.org/10.1016/j.archoralbio.2019.104600" @default.
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