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- W2986700091 abstract "Polysaccharide from Grifola frondosa is an excellent metal-ion chelating agent owing to its distinctive structure and outstanding functional activities. Our previous research has successfully synthesized novel organic chromium derived from the chelation of G. frondosa polysaccharide-chromium (III) [GFP-Cr(III)]. The purpose of present research was to reveal the hypoglycemic and hypolipidemic mechanism of GFP-Cr(III), and its relationship with the modulation of intestinal microflora. Successful fabrication of GFP-Cr(III) was verified by thermogravimetric analysis (TGA), powder X-ray diffraction (XRD) and 1H NMR spectrum. The hypoglycemic and hypolipidemic effects were examined using type 2 diabetic mice induced by a high-fat diet (HFD) and streptozocin (STZ). Results indicated that GFP-Cr(III) intervention improved abnormal serum biochemical indicators (triglyceride (TG), cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and glucose), inhibited lipid accumulation and steatosis in the liver. Metagenomic analysis revealed that GFP-Cr(III) treatment produced obvious changes on the intestinal microflora in T2DM mice. The correlation network analysis further revealed that the serum and hepatic lipid profiles were positively correlated with Streptococcus and Enterococcus, but negatively correlated with Enterorhabdus, Ruminococcaceae-UCG-011, Coriobacteriaceae and Micrococcaceae. Meanwhile, oral administration with GFP-Cr(III) regulated the mRNA expression related to glucose and lipid metabolism. These results of present study suggest that GFP-Cr(III) could be used as potential functional food ingredients for the amelioration of hyperglycemia and hyperlipidemia." @default.
- W2986700091 created "2019-11-22" @default.
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- W2986700091 date "2020-02-01" @default.
- W2986700091 modified "2023-10-02" @default.
- W2986700091 title "Hypoglycemic and hypolipidemic mechanism of organic chromium derived from chelation of Grifola frondosa polysaccharide-chromium (III) and its modulation of intestinal microflora in high fat-diet and STZ-induced diabetic mice" @default.
- W2986700091 cites W1580768328 @default.
- W2986700091 cites W1987033858 @default.
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- W2986700091 cites W2030698401 @default.
- W2986700091 cites W2033492964 @default.
- W2986700091 cites W2034810986 @default.
- W2986700091 cites W2037590998 @default.
- W2986700091 cites W2053530099 @default.
- W2986700091 cites W2056856345 @default.
- W2986700091 cites W2068183058 @default.
- W2986700091 cites W2086560185 @default.
- W2986700091 cites W2086609292 @default.
- W2986700091 cites W2112291880 @default.
- W2986700091 cites W2126602792 @default.
- W2986700091 cites W2132399049 @default.
- W2986700091 cites W2140849098 @default.
- W2986700091 cites W2168261002 @default.
- W2986700091 cites W2170203388 @default.
- W2986700091 cites W2192244866 @default.
- W2986700091 cites W2220151442 @default.
- W2986700091 cites W2235603614 @default.
- W2986700091 cites W2319967630 @default.
- W2986700091 cites W2374285893 @default.
- W2986700091 cites W2395121817 @default.
- W2986700091 cites W2404355916 @default.
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- W2986700091 cites W2516285945 @default.
- W2986700091 cites W2523562287 @default.
- W2986700091 cites W2588162513 @default.
- W2986700091 cites W2753558181 @default.
- W2986700091 cites W2755695100 @default.
- W2986700091 cites W2763518393 @default.
- W2986700091 cites W2774621382 @default.
- W2986700091 cites W2781607585 @default.
- W2986700091 cites W2793650324 @default.
- W2986700091 cites W2794354802 @default.
- W2986700091 cites W2800035564 @default.
- W2986700091 cites W2803111352 @default.
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- W2986700091 doi "https://doi.org/10.1016/j.ijbiomac.2019.09.206" @default.
- W2986700091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31726162" @default.
- W2986700091 hasPublicationYear "2020" @default.
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