FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2986717577> ?p ?o ?g. }

• W2986717577 endingPage "267" @default.
• W2986717577 startingPage "258" @default.
• W2986717577 abstract "Patterns observed by examining the evolutionary relationships among proteins of common origin can reveal the structural and functional importance of specific residue positions. In particular, amino acids that are highly conserved (i.e., their positions evolve at a slower rate than other positions) are particularly likely to be of biological importance, for example, for ligand binding. ConSurf is a bioinformatics tool for accurately estimating the evolutionary rate of each position in a protein family. Here we introduce a new release of ConSurf-DB, a database of precalculated ConSurf evolutionary conservation profiles for proteins of known structure. ConSurf-DB provides high-accuracy estimates of the evolutionary rates of the amino acids in each protein. A reliable estimate of a query protein's evolutionary rates depends on having a sufficiently large number of effective homologues (i.e., nonredundant yet sufficiently similar). With current sequence data, ConSurf-DB covers 82% of the PDB proteins. It will be updated on a regular basis to ensure that coverage remains high-and that it might even increase. Much effort was dedicated to improving the user experience. The repository is available at https://consurfdb.tau.ac.il/. BROADER AUDIENCE: By comparing a protein to other proteins of similar origin, it is possible to determine the extent to which each amino acid position in the protein evolved slowly or rapidly. A protein's evolutionary profile can provide valuable insights: For example, amino acid positions that are highly conserved (i.e., evolved slowly) are particularly likely to be of structural and/or functional importance, for example, for ligand binding and catalysis. We introduce here a new and improved version of ConSurf-DB, a continually updated database that provides precalculated evolutionary profiles of proteins with known structure." @default.
• W2986717577 created "2019-11-22" @default.
• W2986717577 creator A5028450007 @default.
• W2986717577 creator A5037671858 @default.
• W2986717577 creator A5039821505 @default.
• W2986717577 creator A5057094793 @default.
• W2986717577 creator A5058123116 @default.
• W2986717577 creator A5067301802 @default.
• W2986717577 creator A5082969872 @default.
• W2986717577 creator A5088415650 @default.
• W2986717577 date "2019-11-22" @default.
• W2986717577 modified "2023-10-17" @default.
• W2986717577 title "ConSurf‐DB: An accessible repository for the evolutionary conservation patterns of the majority of PDB proteins" @default.
• W2986717577 cites W1965582988 @default.
• W2986717577 cites W1967293793 @default.
• W2986717577 cites W2003788979 @default.
• W2986717577 cites W2013357048 @default.
• W2986717577 cites W2017519756 @default.
• W2986717577 cites W2024341709 @default.
• W2986717577 cites W2040481795 @default.
• W2986717577 cites W2051872583 @default.
• W2986717577 cites W2054668663 @default.
• W2986717577 cites W2062018285 @default.
• W2986717577 cites W2069119484 @default.
• W2986717577 cites W2069152576 @default.
• W2986717577 cites W2076048958 @default.
• W2986717577 cites W2077539484 @default.
• W2986717577 cites W2096702350 @default.
• W2986717577 cites W2102461176 @default.
• W2986717577 cites W2102652793 @default.
• W2986717577 cites W2110094991 @default.
• W2986717577 cites W2116099439 @default.
• W2986717577 cites W2125314454 @default.
• W2986717577 cites W2127774996 @default.
• W2986717577 cites W2130479394 @default.
• W2986717577 cites W2132629607 @default.
• W2986717577 cites W2137071423 @default.
• W2986717577 cites W2139134537 @default.
• W2986717577 cites W2143776567 @default.
• W2986717577 cites W2150444353 @default.
• W2986717577 cites W2153153865 @default.
• W2986717577 cites W2154139219 @default.
• W2986717577 cites W2156125289 @default.
• W2986717577 cites W2160297538 @default.
• W2986717577 cites W2160378127 @default.
• W2986717577 cites W2162574056 @default.
• W2986717577 cites W2163352757 @default.
• W2986717577 cites W2163627198 @default.
• W2986717577 cites W2167689124 @default.
• W2986717577 cites W2170747616 @default.
• W2986717577 cites W2170968124 @default.
• W2986717577 cites W2376573086 @default.
• W2986717577 cites W2521298622 @default.
• W2986717577 cites W2751476102 @default.
• W2986717577 cites W2806399642 @default.
• W2986717577 cites W2898364362 @default.
• W2986717577 cites W3136918052 @default.
• W2986717577 cites W4237007771 @default.
• W2986717577 doi "https://doi.org/10.1002/pro.3779" @default.
• W2986717577 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6933843" @default.
• W2986717577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31702846" @default.
• W2986717577 hasPublicationYear "2019" @default.
• W2986717577 type Work @default.
• W2986717577 sameAs 2986717577 @default.
• W2986717577 citedByCount "72" @default.
• W2986717577 countsByYear W29867175772020 @default.
• W2986717577 countsByYear W29867175772021 @default.
• W2986717577 countsByYear W29867175772022 @default.
• W2986717577 countsByYear W29867175772023 @default.
• W2986717577 crossrefType "journal-article" @default.
• W2986717577 hasAuthorship W2986717577A5028450007 @default.
• W2986717577 hasAuthorship W2986717577A5037671858 @default.
• W2986717577 hasAuthorship W2986717577A5039821505 @default.
• W2986717577 hasAuthorship W2986717577A5057094793 @default.
• W2986717577 hasAuthorship W2986717577A5058123116 @default.
• W2986717577 hasAuthorship W2986717577A5067301802 @default.
• W2986717577 hasAuthorship W2986717577A5082969872 @default.
• W2986717577 hasAuthorship W2986717577A5088415650 @default.
• W2986717577 hasBestOaLocation W29867175771 @default.
• W2986717577 hasConcept C199216141 @default.
• W2986717577 hasConcept C3017666073 @default.
• W2986717577 hasConcept C41008148 @default.
• W2986717577 hasConcept C54355233 @default.
• W2986717577 hasConcept C552990157 @default.
• W2986717577 hasConcept C55493867 @default.
• W2986717577 hasConcept C60644358 @default.
• W2986717577 hasConcept C65556437 @default.
• W2986717577 hasConcept C70721500 @default.
• W2986717577 hasConcept C78458016 @default.
• W2986717577 hasConcept C86803240 @default.
• W2986717577 hasConceptScore W2986717577C199216141 @default.
• W2986717577 hasConceptScore W2986717577C3017666073 @default.
• W2986717577 hasConceptScore W2986717577C41008148 @default.
• W2986717577 hasConceptScore W2986717577C54355233 @default.
• W2986717577 hasConceptScore W2986717577C552990157 @default.
• W2986717577 hasConceptScore W2986717577C55493867 @default.
• W2986717577 hasConceptScore W2986717577C60644358 @default.
• W2986717577 hasConceptScore W2986717577C65556437 @default.

• next