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- W2986744827 abstract "Maintenance of an appropriate oxygen concentration is essential for the function of the liver. However, in many pathological conditions, and particularly in the tumor microenvironment, cells and tissues are frequently in a hypoxic state. In the presence of hypoxia, the cells adapt to the low oxygen levels through the hypoxia‑inducible factor (HIF) pathway. Overgrowth of tumor cells restricts the diffusion of oxygen in tumors, leading to insufficient blood supply and the creation of a hypoxic microenvironment, and, as a consequence, activation of the expression of HIFs. HIFs possess a wide range of target genes, which function to control a variety of signaling pathways; thus, HIFs modulate cellular metabolism, immune escape, angiogenesis, metastasis, extracellular matrix remodeling, cancer stem cells and other properties of the tumor. Given their crucial role in the occurrence and development of tumors, HIFs are expected to become new targets of precise treatment of hepatocellular carcinoma." @default.
- W2986744827 created "2019-11-22" @default.
- W2986744827 creator A5000147534 @default.
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- W2986744827 date "2019-11-01" @default.
- W2986744827 modified "2023-09-30" @default.
- W2986744827 title "Hypoxia‑inducible factors in hepatocellular carcinoma (Review)" @default.
- W2986744827 cites W1010999108 @default.
- W2986744827 cites W1498451757 @default.
- W2986744827 cites W1550989298 @default.
- W2986744827 cites W1580865462 @default.
- W2986744827 cites W1749022239 @default.
- W2986744827 cites W1908276267 @default.
- W2986744827 cites W1965498876 @default.
- W2986744827 cites W1968248545 @default.
- W2986744827 cites W1970311419 @default.
- W2986744827 cites W1973614037 @default.
- W2986744827 cites W1975726973 @default.
- W2986744827 cites W1978577068 @default.
- W2986744827 cites W1983443820 @default.
- W2986744827 cites W1984369648 @default.
- W2986744827 cites W1985642671 @default.
- W2986744827 cites W1987974662 @default.
- W2986744827 cites W1988380443 @default.
- W2986744827 cites W1991796034 @default.
- W2986744827 cites W1993873907 @default.
- W2986744827 cites W1994450509 @default.
- W2986744827 cites W1996022540 @default.
- W2986744827 cites W1996463890 @default.
- W2986744827 cites W1997889852 @default.
- W2986744827 cites W2004941068 @default.
- W2986744827 cites W2011053463 @default.
- W2986744827 cites W2011376105 @default.
- W2986744827 cites W2011615798 @default.
- W2986744827 cites W2018722597 @default.
- W2986744827 cites W2022427127 @default.
- W2986744827 cites W2023259982 @default.
- W2986744827 cites W2027121745 @default.
- W2986744827 cites W2028506395 @default.
- W2986744827 cites W2029175400 @default.
- W2986744827 cites W2033526132 @default.
- W2986744827 cites W2033958147 @default.
- W2986744827 cites W2035266548 @default.
- W2986744827 cites W2035396934 @default.
- W2986744827 cites W2035983112 @default.
- W2986744827 cites W2038974826 @default.
- W2986744827 cites W2039775393 @default.
- W2986744827 cites W2040031153 @default.
- W2986744827 cites W2046605553 @default.
- W2986744827 cites W2057366549 @default.
- W2986744827 cites W2058837304 @default.
- W2986744827 cites W2066379425 @default.
- W2986744827 cites W2069698188 @default.
- W2986744827 cites W2071361463 @default.
- W2986744827 cites W2073731809 @default.
- W2986744827 cites W2075109680 @default.
- W2986744827 cites W2082525702 @default.
- W2986744827 cites W2083573359 @default.
- W2986744827 cites W2087408685 @default.
- W2986744827 cites W2091068407 @default.
- W2986744827 cites W2091788036 @default.
- W2986744827 cites W2093014461 @default.
- W2986744827 cites W2095510412 @default.
- W2986744827 cites W2098134455 @default.
- W2986744827 cites W2102322990 @default.
- W2986744827 cites W2102416115 @default.
- W2986744827 cites W2102476325 @default.
- W2986744827 cites W2103214055 @default.
- W2986744827 cites W2104108149 @default.
- W2986744827 cites W2104551938 @default.
- W2986744827 cites W2107297677 @default.
- W2986744827 cites W2108517168 @default.
- W2986744827 cites W2110085982 @default.
- W2986744827 cites W2116159404 @default.
- W2986744827 cites W2122012410 @default.
- W2986744827 cites W2127491141 @default.
- W2986744827 cites W2131931500 @default.
- W2986744827 cites W2136875815 @default.
- W2986744827 cites W2137090229 @default.
- W2986744827 cites W2137547292 @default.
- W2986744827 cites W2142786915 @default.
- W2986744827 cites W2144954025 @default.
- W2986744827 cites W2145306792 @default.
- W2986744827 cites W2146260726 @default.
- W2986744827 cites W2147718842 @default.
- W2986744827 cites W2151713424 @default.
- W2986744827 cites W2153895029 @default.
- W2986744827 cites W2154576630 @default.
- W2986744827 cites W2157177585 @default.
- W2986744827 cites W2158794894 @default.
- W2986744827 cites W2158821976 @default.
- W2986744827 cites W2163823536 @default.
- W2986744827 cites W2173592022 @default.
- W2986744827 cites W2186266682 @default.