FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2986759968> ?p ?o ?g. }

• W2986759968 abstract "Synaptic dopamine (DA) is mainly regulated by the presynaptic DA transporter (DAT). Single-photon emission computerized tomography (SPECT) with the DAT radiotracer [123I]FP-CIT assesses changes in synaptic DA availability when endogenous DA displaces [123I]FP-CIT or competes for DAT. Here, we investigated the effects of haloperidol (HAL) and clozapine (CLZ) on [123I]FP-CIT binding in the rat striatum and midbrain to assess the utility of [123I]FP-CIT SPECT to quantify changes in synaptic DA availability. Rats underwent [123I]FP-CIT SPECT after intraperitoneal administration of normal saline (vehicle), HAL (1 and 7 mg/kg), CLZ (10 and 54 mg/kg) and bupropion (BUP, a DAT blocker, 20 and 100 mg/kg). In the striatum and midbrain, percent differences in the nondisplaceable binding potential (BPND) of [123I]FP-CIT compared to the vehicle were calculated for the various drugs and doses. In another experiment, changes in endogenous striatal DA concentration were measured by in vivo microdialysis under the conditions used in the SPECT study. BUP dose-dependently occupied DAT at considerable levels. Compared to the vehicle, HAL decreased [123I]FP-CIT BPND in the striatum (-25.29% and -2.27% for 1 and 7 mg/kg, respectively) and to a greater degree in the midbrain (-58.74% and -49.64% for 1 and 7 mg/kg, respectively), whereas the CLZ-treated group showed a decrease in the midbrain (-38.60% and -40.38% for 10 and 54 mg/kg, respectively) but an increase in the striatum (18.85% and 38.64% for 10 and 54 mg/kg, respectively). Antipsychotic-induced changes in endogenous striatal DA concentrations varied across drugs and doses. The data demonstrate that [123I]FP-CIT SPECT may be a useful preclinical technique for detecting increases in synaptic DA availability in the midbrain and striatum in response to HAL, with results comparable to those of in vivo microdialysis." @default.
• W2986759968 created "2019-11-22" @default.
• W2986759968 creator A5007611070 @default.
• W2986759968 creator A5020627389 @default.
• W2986759968 creator A5022935280 @default.
• W2986759968 creator A5045189061 @default.
• W2986759968 creator A5045337799 @default.
• W2986759968 creator A5066394949 @default.
• W2986759968 date "2019-10-31" @default.
• W2986759968 modified "2023-10-17" @default.
• W2986759968 title "Combination of In Vivo [123I]FP-CIT SPECT and Microdialysis Reveals an Antipsychotic Drug Haloperidol-induced Synaptic Dopamine Availability in the Rat Midbrain and Striatum" @default.
• W2986759968 cites W1764194029 @default.
• W2986759968 cites W1838041407 @default.
• W2986759968 cites W1925492557 @default.
• W2986759968 cites W1945720487 @default.
• W2986759968 cites W1969169028 @default.
• W2986759968 cites W1970507402 @default.
• W2986759968 cites W1973188992 @default.
• W2986759968 cites W1974898145 @default.
• W2986759968 cites W1976846700 @default.
• W2986759968 cites W1980773450 @default.
• W2986759968 cites W1983193398 @default.
• W2986759968 cites W1986748661 @default.
• W2986759968 cites W2000858615 @default.
• W2986759968 cites W2020502982 @default.
• W2986759968 cites W2022725791 @default.
• W2986759968 cites W2030148308 @default.
• W2986759968 cites W2031121115 @default.
• W2986759968 cites W2035229535 @default.
• W2986759968 cites W2052500414 @default.
• W2986759968 cites W2058784273 @default.
• W2986759968 cites W2068026066 @default.
• W2986759968 cites W2068876663 @default.
• W2986759968 cites W2079985430 @default.
• W2986759968 cites W2080423091 @default.
• W2986759968 cites W2082175181 @default.
• W2986759968 cites W2084909071 @default.
• W2986759968 cites W2092416470 @default.
• W2986759968 cites W2104465880 @default.
• W2986759968 cites W2108772940 @default.
• W2986759968 cites W2114949911 @default.
• W2986759968 cites W2118035595 @default.
• W2986759968 cites W2126060120 @default.
• W2986759968 cites W2128407929 @default.
• W2986759968 cites W2128480619 @default.
• W2986759968 cites W2135925171 @default.
• W2986759968 cites W2143857681 @default.
• W2986759968 cites W2147936404 @default.
• W2986759968 cites W2162992596 @default.
• W2986759968 cites W2171512901 @default.
• W2986759968 cites W2396393259 @default.
• W2986759968 cites W2547034751 @default.
• W2986759968 cites W2590126519 @default.
• W2986759968 cites W2802993096 @default.
• W2986759968 cites W4297913044 @default.
• W2986759968 cites W45776812 @default.
• W2986759968 doi "https://doi.org/10.5607/en.2019.28.5.602" @default.
• W2986759968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6844836" @default.
• W2986759968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31698552" @default.
• W2986759968 hasPublicationYear "2019" @default.
• W2986759968 type Work @default.
• W2986759968 sameAs 2986759968 @default.
• W2986759968 citedByCount "4" @default.
• W2986759968 countsByYear W29867599682020 @default.
• W2986759968 countsByYear W29867599682022 @default.
• W2986759968 crossrefType "journal-article" @default.
• W2986759968 hasAuthorship W2986759968A5007611070 @default.
• W2986759968 hasAuthorship W2986759968A5020627389 @default.
• W2986759968 hasAuthorship W2986759968A5022935280 @default.
• W2986759968 hasAuthorship W2986759968A5045189061 @default.
• W2986759968 hasAuthorship W2986759968A5045337799 @default.
• W2986759968 hasAuthorship W2986759968A5066394949 @default.
• W2986759968 hasBestOaLocation W29867599681 @default.
• W2986759968 hasConcept C126322002 @default.
• W2986759968 hasConcept C134018914 @default.
• W2986759968 hasConcept C137183658 @default.
• W2986759968 hasConcept C185592680 @default.
• W2986759968 hasConcept C2776755682 @default.
• W2986759968 hasConcept C2780062018 @default.
• W2986759968 hasConcept C2780948584 @default.
• W2986759968 hasConcept C50156730 @default.
• W2986759968 hasConcept C513476851 @default.
• W2986759968 hasConcept C529278444 @default.
• W2986759968 hasConcept C552161191 @default.
• W2986759968 hasConcept C71924100 @default.
• W2986759968 hasConcept C98274493 @default.
• W2986759968 hasConceptScore W2986759968C126322002 @default.
• W2986759968 hasConceptScore W2986759968C134018914 @default.
• W2986759968 hasConceptScore W2986759968C137183658 @default.
• W2986759968 hasConceptScore W2986759968C185592680 @default.
• W2986759968 hasConceptScore W2986759968C2776755682 @default.
• W2986759968 hasConceptScore W2986759968C2780062018 @default.
• W2986759968 hasConceptScore W2986759968C2780948584 @default.
• W2986759968 hasConceptScore W2986759968C50156730 @default.
• W2986759968 hasConceptScore W2986759968C513476851 @default.
• W2986759968 hasConceptScore W2986759968C529278444 @default.
• W2986759968 hasConceptScore W2986759968C552161191 @default.
• W2986759968 hasConceptScore W2986759968C71924100 @default.
• W2986759968 hasConceptScore W2986759968C98274493 @default.
• W2986759968 hasFunder F4320322030 @default.

• next