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- W2986875327 abstract "Age-related macular degeneration (AMD) remains the leading cause of blindness in elderly people, but the pathophysiology of this disease is still largely unknown. We investigated the systemic expression of angiogenesis-regulating growth factors and selected miRNAs known to regulate angiogenesis in AMD patients. We also focused on possible correlations of their expression with the presence of CFH Y402H or ARMS A69S risk variants. A total of 354 AMD patients and 121 controls were enrolled in this study. The levels of angiogenesis-regulating factors were analyzed in plasma samples using Luminex technology. The expression of selected miRNAs was analyzed in peripheral blood plasma using real-time qPCR. The genetic analysis was performed with an Illumina NextSeq500 system. AMD was an independent factor associated with lower levels of angiogenin (β = −0.29, p < 0.001), endostatin (β = −0.18, p < 0.001), FGF-basic (β = −0.18, p < 0.001), PlGF (β = −0.24, p < 0.001), miRNA-21-3p (β = −0.13, p = 0.01) and miRNA-155-5p (β = −0.16, p = 0.002); and with higher levels of FGF-acidic (β = 0.11, p = 0.03), miRNA-23a-3p (β = 0.17, p < 0.001), miRNA-126-5p (β = 0.13, p = 0.009), miRNA-16-5p (β = 0.40, p < 0.001), miRNA-17-3p (β = 0.13, p = 0.01), miRNA-17-5p (β = 0.17, p < 0.001), miRNA-223-3p (β = 0.15, p = 0.004), and miRNA-93 (β = 0.11, p = 0.04). The expression of analyzed miRNA molecules significantly correlated with the levels of tested angiogenesis-regulating factors and clinical parameters in AMD patients, whereas such correlations were not observed in controls. We also found an association between the CFH Y402H polymorphism and miRNA profiles, whereby TT homozygotes showed evidently higher expression of miRNA-16-5p than CC homozygotes or TC heterozygotes (p = 0.0007). Our results suggest that the balance between systemic pro- and anti-angiogenic factors and miRNAs is vital in multifactorial AMD pathogenesis." @default.
- W2986875327 created "2019-11-22" @default.
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- W2986875327 date "2019-11-15" @default.
- W2986875327 modified "2023-10-14" @default.
- W2986875327 title "Associations of MicroRNAs, Angiogenesis-Regulating Factors and CFH Y402H Polymorphism—An Attempt to Search for Systemic Biomarkers in Age-Related Macular Degeneration" @default.
- W2986875327 cites W1089052599 @default.
- W2986875327 cites W1501997379 @default.
- W2986875327 cites W1534760353 @default.
- W2986875327 cites W1576012659 @default.
- W2986875327 cites W1578173684 @default.
- W2986875327 cites W158938192 @default.
- W2986875327 cites W1919257374 @default.
- W2986875327 cites W1968904691 @default.
- W2986875327 cites W1973118519 @default.
- W2986875327 cites W1976384923 @default.
- W2986875327 cites W1987126756 @default.
- W2986875327 cites W1988077870 @default.
- W2986875327 cites W1990301804 @default.
- W2986875327 cites W1994719482 @default.
- W2986875327 cites W1995340861 @default.
- W2986875327 cites W1997623840 @default.
- W2986875327 cites W1998525239 @default.
- W2986875327 cites W2006298215 @default.
- W2986875327 cites W2008304553 @default.
- W2986875327 cites W2025252582 @default.
- W2986875327 cites W2027875367 @default.
- W2986875327 cites W2031678227 @default.
- W2986875327 cites W2032768676 @default.
- W2986875327 cites W2035743945 @default.
- W2986875327 cites W2036897871 @default.
- W2986875327 cites W2036923470 @default.
- W2986875327 cites W2037348124 @default.
- W2986875327 cites W2039150416 @default.
- W2986875327 cites W2039794526 @default.
- W2986875327 cites W2042034090 @default.
- W2986875327 cites W2052397130 @default.
- W2986875327 cites W2056392188 @default.
- W2986875327 cites W2063186163 @default.
- W2986875327 cites W2073534453 @default.
- W2986875327 cites W2089946654 @default.
- W2986875327 cites W2091576301 @default.
- W2986875327 cites W2093646832 @default.
- W2986875327 cites W2103441770 @default.
- W2986875327 cites W2110733383 @default.
- W2986875327 cites W2110943754 @default.
- W2986875327 cites W2111044102 @default.
- W2986875327 cites W2114112168 @default.
- W2986875327 cites W2131798870 @default.
- W2986875327 cites W2140931030 @default.
- W2986875327 cites W2149440805 @default.
- W2986875327 cites W2150767213 @default.
- W2986875327 cites W2162415186 @default.
- W2986875327 cites W2168057091 @default.
- W2986875327 cites W2175574776 @default.
- W2986875327 cites W2213421734 @default.
- W2986875327 cites W2230804447 @default.
- W2986875327 cites W2310003175 @default.
- W2986875327 cites W2313043717 @default.
- W2986875327 cites W2342643431 @default.
- W2986875327 cites W2347205644 @default.
- W2986875327 cites W2399798984 @default.
- W2986875327 cites W2407915694 @default.
- W2986875327 cites W2411860059 @default.
- W2986875327 cites W2412434883 @default.
- W2986875327 cites W2414824006 @default.
- W2986875327 cites W2417483443 @default.
- W2986875327 cites W2460407087 @default.
- W2986875327 cites W2521207889 @default.
- W2986875327 cites W2530911331 @default.
- W2986875327 cites W2537276878 @default.
- W2986875327 cites W2552510066 @default.
- W2986875327 cites W2559556008 @default.
- W2986875327 cites W2599586899 @default.
- W2986875327 cites W2710560069 @default.
- W2986875327 cites W2734136842 @default.
- W2986875327 cites W2735153727 @default.
- W2986875327 cites W2747725012 @default.
- W2986875327 cites W2763114619 @default.
- W2986875327 cites W2768379464 @default.
- W2986875327 cites W2769785917 @default.
- W2986875327 cites W2772569182 @default.
- W2986875327 cites W2811428863 @default.
- W2986875327 cites W2884169738 @default.
- W2986875327 cites W2948037662 @default.
- W2986875327 cites W2981423461 @default.