FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2987117152> ?p ?o ?g. }

• W2987117152 endingPage "1812" @default.
• W2987117152 startingPage "1812" @default.
• W2987117152 abstract "Osteosarcoma (OS) originates from osteoid bone tissues and is prone to metastasis, resulting in a high mortality rate. Although several treatments are available for OS, an effective cure does not exist for most patients with advanced OS. Zoledronic acid (ZOL) is a third-generation bisphosphonate that inhibits osteoclast-mediated bone resorption and has shown efficacy in treating bone metastases in patients with various types of solid tumors. Here, we sought to clarify the mechanisms through which ZOL inhibits OS cell proliferation. ZOL treatment inhibited OS cell proliferation, viability, and colony formation. Autophagy inhibition by RNA interference against Beclin-1 or ATG5 inhibited ZOL-induced OS cell death. ZOL induced autophagy by repressing the protein kinase B/mammalian target of rapamycin/p70S6 kinase pathway and extracellular signal-regulated kinase signaling-dependent autophagy in OS cell lines and patient-derived OS cells. Microarrays of miRNA showed that ZOL increased the levels of miR-212-3p, which is known to play an important role in autophagy, in OS in vitro and in vivo systems. Collectively, our data provided mechanistic insight into how increased miR-212-3p through ZOL treatment induces autophagy synergistically in OS cells, providing a preclinical rationale for conducting a broad-scale clinical evaluation of ZOL + miR-212-3p in treating OS." @default.
• W2987117152 created "2019-11-22" @default.
• W2987117152 creator A5027327441 @default.
• W2987117152 creator A5028760033 @default.
• W2987117152 creator A5031054461 @default.
• W2987117152 creator A5036533905 @default.
• W2987117152 creator A5037066787 @default.
• W2987117152 creator A5049271168 @default.
• W2987117152 creator A5059553965 @default.
• W2987117152 creator A5075799416 @default.
• W2987117152 creator A5077347905 @default.
• W2987117152 creator A5079387134 @default.
• W2987117152 creator A5079842484 @default.
• W2987117152 creator A5081016797 @default.
• W2987117152 creator A5086510739 @default.
• W2987117152 date "2019-11-18" @default.
• W2987117152 modified "2023-10-04" @default.
• W2987117152 title "Synergistic Autophagy Effect of miR-212-3p in Zoledronic Acid-Treated In Vitro and Orthotopic In Vivo Models and in Patient-Derived Osteosarcoma Cells" @default.
• W2987117152 cites W146224257 @default.
• W2987117152 cites W1516720130 @default.
• W2987117152 cites W1523693806 @default.
• W2987117152 cites W1528417811 @default.
• W2987117152 cites W1608453139 @default.
• W2987117152 cites W1870776631 @default.
• W2987117152 cites W1972551831 @default.
• W2987117152 cites W1975200363 @default.
• W2987117152 cites W1976836551 @default.
• W2987117152 cites W1979952830 @default.
• W2987117152 cites W1983788491 @default.
• W2987117152 cites W1992331328 @default.
• W2987117152 cites W2006851815 @default.
• W2987117152 cites W2008373622 @default.
• W2987117152 cites W2013571231 @default.
• W2987117152 cites W2016040396 @default.
• W2987117152 cites W2022114614 @default.
• W2987117152 cites W2049528479 @default.
• W2987117152 cites W2053290255 @default.
• W2987117152 cites W2057274775 @default.
• W2987117152 cites W2065278349 @default.
• W2987117152 cites W2077397852 @default.
• W2987117152 cites W2077546229 @default.
• W2987117152 cites W2078087468 @default.
• W2987117152 cites W2078911476 @default.
• W2987117152 cites W2082972770 @default.
• W2987117152 cites W2084946596 @default.
• W2987117152 cites W2090748725 @default.
• W2987117152 cites W2093275318 @default.
• W2987117152 cites W2110279866 @default.
• W2987117152 cites W2112084862 @default.
• W2987117152 cites W2115871403 @default.
• W2987117152 cites W2126753949 @default.
• W2987117152 cites W2130934441 @default.
• W2987117152 cites W2137649483 @default.
• W2987117152 cites W2137709331 @default.
• W2987117152 cites W2138220544 @default.
• W2987117152 cites W2139503978 @default.
• W2987117152 cites W2140813472 @default.
• W2987117152 cites W2142234592 @default.
• W2987117152 cites W2147859079 @default.
• W2987117152 cites W2160079255 @default.
• W2987117152 cites W2160737079 @default.
• W2987117152 cites W2321334553 @default.
• W2987117152 cites W2359386156 @default.
• W2987117152 cites W2519034150 @default.
• W2987117152 cites W2526927040 @default.
• W2987117152 cites W2617254461 @default.
• W2987117152 cites W2743384359 @default.
• W2987117152 cites W2903348486 @default.
• W2987117152 cites W2964743865 @default.
• W2987117152 doi "https://doi.org/10.3390/cancers11111812" @default.
• W2987117152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6895802" @default.
• W2987117152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31752184" @default.
• W2987117152 hasPublicationYear "2019" @default.
• W2987117152 type Work @default.
• W2987117152 sameAs 2987117152 @default.
• W2987117152 citedByCount "10" @default.
• W2987117152 countsByYear W29871171522020 @default.
• W2987117152 countsByYear W29871171522021 @default.
• W2987117152 countsByYear W29871171522022 @default.
• W2987117152 countsByYear W29871171522023 @default.
• W2987117152 crossrefType "journal-article" @default.
• W2987117152 hasAuthorship W2987117152A5027327441 @default.
• W2987117152 hasAuthorship W2987117152A5028760033 @default.
• W2987117152 hasAuthorship W2987117152A5031054461 @default.
• W2987117152 hasAuthorship W2987117152A5036533905 @default.
• W2987117152 hasAuthorship W2987117152A5037066787 @default.
• W2987117152 hasAuthorship W2987117152A5049271168 @default.
• W2987117152 hasAuthorship W2987117152A5059553965 @default.
• W2987117152 hasAuthorship W2987117152A5075799416 @default.
• W2987117152 hasAuthorship W2987117152A5077347905 @default.
• W2987117152 hasAuthorship W2987117152A5079387134 @default.
• W2987117152 hasAuthorship W2987117152A5079842484 @default.
• W2987117152 hasAuthorship W2987117152A5081016797 @default.
• W2987117152 hasAuthorship W2987117152A5086510739 @default.
• W2987117152 hasBestOaLocation W29871171521 @default.
• W2987117152 hasConcept C126322002 @default.
• W2987117152 hasConcept C150903083 @default.
• W2987117152 hasConcept C184235292 @default.

• next