FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2987130760> ?p ?o ?g. }

• W2987130760 endingPage "109349" @default.
• W2987130760 startingPage "109349" @default.
• W2987130760 abstract "Polyglycolic acid (PGA) is a typical polyester with successful clinical and commercial applications. It causes severe host response and needs modification according to clinical cases. The expression of the pro-healing cytokine, IL-10, from macrophages as indicators of immune-response to PGA medical devices can be the key to be revealed. We thereby intended to modify PGA to affect its degradation profile and modulate the secretion of cytokines by macrophages. Sodium tripolyphosphate (TPP) was incorporated into PGA scaffolds as fillers via a scCO2 foaming process. A porcine subcutaneous model was further employed to evaluate the inflammation and the expression profiles of macrophages (IL-10 and IL-1β as well as their phenotypes) in these implants. It was shown that IL-1β and IL-6 were both inhibited in vitro in PGA and PGA-TPP groups without dependence on pH. The secretion of TNF-α was stimulated when pH was 6.1 and was inhibited by acidosis with pH of 3.6. IL-10 was also suppressed when pH was 3.6. In vivo expression of IL-1β was increased in both groups. However, IL-10 exhibited higher values in PGA-TPP group than in PGA one, although a decreasing trend appeared in PGA-TPP implants from the 2nd to the 4th week. The infiltration of leukocytes was still severe in PGA scaffolds after two weeks post-surgery, while this was evidently relieved in PGA-TPP ones. In summary, the incorporation of TPP into PGA implants could be an efficient way to relief the inflammatory response and to improve the clinical outcomes of translational polyester implants." @default.
• W2987130760 created "2019-11-22" @default.
• W2987130760 creator A5018007380 @default.
• W2987130760 creator A5024230239 @default.
• W2987130760 creator A5028828602 @default.
• W2987130760 creator A5030841645 @default.
• W2987130760 creator A5035287322 @default.
• W2987130760 creator A5055977368 @default.
• W2987130760 creator A5074173740 @default.
• W2987130760 date "2020-01-01" @default.
• W2987130760 modified "2023-10-17" @default.
• W2987130760 title "Regulation of inflammatory response to polyglycolic acid scaffolds through incorporation of sodium tripolyphosphate" @default.
• W2987130760 cites W1486200716 @default.
• W2987130760 cites W1672848901 @default.
• W2987130760 cites W1968339853 @default.
• W2987130760 cites W1975117977 @default.
• W2987130760 cites W1978518757 @default.
• W2987130760 cites W1984016972 @default.
• W2987130760 cites W1988635537 @default.
• W2987130760 cites W2006540005 @default.
• W2987130760 cites W2016844038 @default.
• W2987130760 cites W2017139528 @default.
• W2987130760 cites W2028161955 @default.
• W2987130760 cites W2038660589 @default.
• W2987130760 cites W2040575016 @default.
• W2987130760 cites W2044242789 @default.
• W2987130760 cites W2045274824 @default.
• W2987130760 cites W2051101763 @default.
• W2987130760 cites W2063632665 @default.
• W2987130760 cites W2069121320 @default.
• W2987130760 cites W2071202308 @default.
• W2987130760 cites W2073659287 @default.
• W2987130760 cites W2085701716 @default.
• W2987130760 cites W2103722820 @default.
• W2987130760 cites W2112771109 @default.
• W2987130760 cites W2113505916 @default.
• W2987130760 cites W2120626152 @default.
• W2987130760 cites W2126392408 @default.
• W2987130760 cites W2130503287 @default.
• W2987130760 cites W2142258375 @default.
• W2987130760 cites W2145639361 @default.
• W2987130760 cites W2157976579 @default.
• W2987130760 cites W2165708288 @default.
• W2987130760 cites W2167830630 @default.
• W2987130760 cites W2301044272 @default.
• W2987130760 cites W2325763682 @default.
• W2987130760 cites W2420925260 @default.
• W2987130760 cites W2516087537 @default.
• W2987130760 cites W2517700447 @default.
• W2987130760 cites W2531611735 @default.
• W2987130760 cites W2545342348 @default.
• W2987130760 cites W2589941896 @default.
• W2987130760 cites W2599741499 @default.
• W2987130760 cites W2609729296 @default.
• W2987130760 cites W2614841288 @default.
• W2987130760 cites W2735803903 @default.
• W2987130760 cites W2768843562 @default.
• W2987130760 cites W2775666728 @default.
• W2987130760 cites W2779523127 @default.
• W2987130760 cites W2796358875 @default.
• W2987130760 cites W2914326108 @default.
• W2987130760 cites W2944324936 @default.
• W2987130760 cites W4206730491 @default.
• W2987130760 doi "https://doi.org/10.1016/j.eurpolymj.2019.109349" @default.
• W2987130760 hasPublicationYear "2020" @default.
• W2987130760 type Work @default.
• W2987130760 sameAs 2987130760 @default.
• W2987130760 citedByCount "8" @default.
• W2987130760 countsByYear W29871307602020 @default.
• W2987130760 countsByYear W29871307602021 @default.
• W2987130760 countsByYear W29871307602022 @default.
• W2987130760 countsByYear W29871307602023 @default.
• W2987130760 crossrefType "journal-article" @default.
• W2987130760 hasAuthorship W2987130760A5018007380 @default.
• W2987130760 hasAuthorship W2987130760A5024230239 @default.
• W2987130760 hasAuthorship W2987130760A5028828602 @default.
• W2987130760 hasAuthorship W2987130760A5030841645 @default.
• W2987130760 hasAuthorship W2987130760A5035287322 @default.
• W2987130760 hasAuthorship W2987130760A5055977368 @default.
• W2987130760 hasAuthorship W2987130760A5074173740 @default.
• W2987130760 hasConcept C150903083 @default.
• W2987130760 hasConcept C153400128 @default.
• W2987130760 hasConcept C159985019 @default.
• W2987130760 hasConcept C178790620 @default.
• W2987130760 hasConcept C185592680 @default.
• W2987130760 hasConcept C192562407 @default.
• W2987130760 hasConcept C202751555 @default.
• W2987130760 hasConcept C203014093 @default.
• W2987130760 hasConcept C207001950 @default.
• W2987130760 hasConcept C2776914184 @default.
• W2987130760 hasConcept C2778690821 @default.
• W2987130760 hasConcept C49039625 @default.
• W2987130760 hasConcept C537181965 @default.
• W2987130760 hasConcept C55493867 @default.
• W2987130760 hasConcept C71924100 @default.
• W2987130760 hasConcept C86803240 @default.
• W2987130760 hasConcept C8891405 @default.
• W2987130760 hasConcept C98274493 @default.

• next