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- W2987133083 abstract "Pattern recognition receptors (PRRs) are sensors of exogenous and endogenous danger signals from pathogen-associated molecular patterns (PAMPs), and damage associated molecular patterns (DAMPs), while autophagy can respond to these signals to control homeostasis. Almost all PRRs can induce autophagy directly or indirectly. Toll-like receptors (TLRs), Nod-like receptors (NLRs), retinoic acid-inducible gene-I-like receptors (RLRs), and cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway can induce autophagy directly through Beclin-1 or LC3-dependent pathway, while the interactions with the receptor for advanced glycation end products (RAGE)/high mobility group box 1 (HMGB1), CD91/Calreticulin, and TLRs/HSPs are achieved by protein, Ca2+, and mitochondrial homeostasis. Autophagy presents antigens to PRRs and helps to clean the pathogens. In addition, the induced autophagy can form a negative feedback regulation of PRRs-mediated inflammation in cell/disease-specific manner to maintain homeostasis and prevent excessive inflammation. Understanding the interaction between PRRs and autophagy in a specific disease will promote drug development for immunotherapy. Here, we focus on the interactions between PRRs and autophagy and how they affect the inflammatory response." @default.
- W2987133083 created "2019-11-22" @default.
- W2987133083 creator A5000500229 @default.
- W2987133083 creator A5021974651 @default.
- W2987133083 creator A5026359889 @default.
- W2987133083 creator A5041819469 @default.
- W2987133083 creator A5048564689 @default.
- W2987133083 creator A5048864350 @default.
- W2987133083 creator A5053441128 @default.
- W2987133083 creator A5053515591 @default.
- W2987133083 date "2019-01-01" @default.
- W2987133083 modified "2023-10-01" @default.
- W2987133083 title "The Interplay Between Pattern Recognition Receptors and Autophagy in Inflammation" @default.
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