FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2987174920> ?p ?o ?g. }

• W2987174920 abstract "Long noncoding RNAs (lncRNAs) are involved in numerous physiological functions. However, their mechanisms in acute myocardial infarction (AMI) are not well understood.We performed an RNA-seq analysis to explore the molecular mechanism of AMI by constructing a lncRNA-miRNA-mRNA axis based on the ceRNA hypothesis. The target microRNA data were used to design a global AMI triple network. Thereafter, a functional enrichment analysis and clustering topological analyses were conducted by using the triple network. The expression of lncRNA SNHG8, SOCS3 and ICAM1 was measured by qRT-PCR. The prognostic values of lncRNA SNHG8, SOCS3 and ICAM1 were evaluated using a receiver operating characteristic (ROC) curve.An AMI lncRNA-miRNA-mRNA network was constructed that included two mRNAs, one miRNA and one lncRNA. After RT-PCR validation of lncRNA SNHG8, SOCS3 and ICAM1 between the AMI and normal samples, only lncRNA SNHG8 had significant diagnostic value for further analysis. The ROC curve showed that SNHG8 presented an AUC of 0.850, while the AUC of SOCS3 was 0.633 and that of ICAM1 was 0.594. After a pairwise comparison, we found that SNHG8 was statistically significant (P SNHG8-ICAM1 = 0.002; P SNHG8-SOCS3 = 0.031). The results of a functional enrichment analysis of the interacting genes and microRNAs showed that the shared lncRNA SNHG8 may be a new factor in AMI.Our investigation of the lncRNA-miRNA-mRNA regulatory networks in AMI revealed a novel lncRNA, lncRNA SNHG8, as a risk factor for AMI and expanded our understanding of the mechanisms involved in the pathogenesis of AMI." @default.
• W2987174920 created "2019-11-22" @default.
• W2987174920 creator A5013570853 @default.
• W2987174920 creator A5031024502 @default.
• W2987174920 creator A5044045871 @default.
• W2987174920 creator A5054870816 @default.
• W2987174920 creator A5055427714 @default.
• W2987174920 creator A5066102428 @default.
• W2987174920 creator A5071654271 @default.
• W2987174920 date "2019-11-18" @default.
• W2987174920 modified "2023-09-26" @default.
• W2987174920 title "LncRNA SNHG8 is identified as a key regulator of acute myocardial infarction by RNA-seq analysis" @default.
• W2987174920 cites W2035618305 @default.
• W2987174920 cites W2046697132 @default.
• W2987174920 cites W2071944562 @default.
• W2987174920 cites W2099374044 @default.
• W2987174920 cites W2113796986 @default.
• W2987174920 cites W2117977572 @default.
• W2987174920 cites W2123479813 @default.
• W2987174920 cites W2125801572 @default.
• W2987174920 cites W2134033103 @default.
• W2987174920 cites W2136850043 @default.
• W2987174920 cites W2146224317 @default.
• W2987174920 cites W2152894234 @default.
• W2987174920 cites W2159612327 @default.
• W2987174920 cites W2159675211 @default.
• W2987174920 cites W2160697532 @default.
• W2987174920 cites W2171398108 @default.
• W2987174920 cites W2198153867 @default.
• W2987174920 cites W2208357705 @default.
• W2987174920 cites W2280289381 @default.
• W2987174920 cites W2315983151 @default.
• W2987174920 cites W2335453170 @default.
• W2987174920 cites W2408279363 @default.
• W2987174920 cites W2431557917 @default.
• W2987174920 cites W2518999583 @default.
• W2987174920 cites W2674744780 @default.
• W2987174920 cites W2744384859 @default.
• W2987174920 cites W2748122449 @default.
• W2987174920 cites W2762559168 @default.
• W2987174920 cites W2781279551 @default.
• W2987174920 cites W2791193877 @default.
• W2987174920 cites W2800934136 @default.
• W2987174920 cites W2809430108 @default.
• W2987174920 cites W2884825556 @default.
• W2987174920 cites W2886886831 @default.
• W2987174920 cites W2888543854 @default.
• W2987174920 cites W2891235718 @default.
• W2987174920 cites W2894197856 @default.
• W2987174920 cites W2900569176 @default.
• W2987174920 cites W2906387824 @default.
• W2987174920 cites W2916543168 @default.
• W2987174920 cites W2921772208 @default.
• W2987174920 cites W2922415061 @default.
• W2987174920 cites W2927312518 @default.
• W2987174920 cites W4238277289 @default.
• W2987174920 doi "https://doi.org/10.1186/s12944-019-1142-0" @default.
• W2987174920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6862811" @default.
• W2987174920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31739782" @default.
• W2987174920 hasPublicationYear "2019" @default.
• W2987174920 type Work @default.
• W2987174920 sameAs 2987174920 @default.
• W2987174920 citedByCount "26" @default.
• W2987174920 countsByYear W29871749202020 @default.
• W2987174920 countsByYear W29871749202021 @default.
• W2987174920 countsByYear W29871749202022 @default.
• W2987174920 countsByYear W29871749202023 @default.
• W2987174920 crossrefType "journal-article" @default.
• W2987174920 hasAuthorship W2987174920A5013570853 @default.
• W2987174920 hasAuthorship W2987174920A5031024502 @default.
• W2987174920 hasAuthorship W2987174920A5044045871 @default.
• W2987174920 hasAuthorship W2987174920A5054870816 @default.
• W2987174920 hasAuthorship W2987174920A5055427714 @default.
• W2987174920 hasAuthorship W2987174920A5066102428 @default.
• W2987174920 hasAuthorship W2987174920A5071654271 @default.
• W2987174920 hasBestOaLocation W29871749201 @default.
• W2987174920 hasConcept C104317684 @default.
• W2987174920 hasConcept C105580179 @default.
• W2987174920 hasConcept C126322002 @default.
• W2987174920 hasConcept C145059251 @default.
• W2987174920 hasConcept C54355233 @default.
• W2987174920 hasConcept C58471807 @default.
• W2987174920 hasConcept C60365752 @default.
• W2987174920 hasConcept C60644358 @default.
• W2987174920 hasConcept C62203573 @default.
• W2987174920 hasConcept C67705224 @default.
• W2987174920 hasConcept C70721500 @default.
• W2987174920 hasConcept C71924100 @default.
• W2987174920 hasConcept C86803240 @default.
• W2987174920 hasConceptScore W2987174920C104317684 @default.
• W2987174920 hasConceptScore W2987174920C105580179 @default.
• W2987174920 hasConceptScore W2987174920C126322002 @default.
• W2987174920 hasConceptScore W2987174920C145059251 @default.
• W2987174920 hasConceptScore W2987174920C54355233 @default.
• W2987174920 hasConceptScore W2987174920C58471807 @default.
• W2987174920 hasConceptScore W2987174920C60365752 @default.
• W2987174920 hasConceptScore W2987174920C60644358 @default.
• W2987174920 hasConceptScore W2987174920C62203573 @default.
• W2987174920 hasConceptScore W2987174920C67705224 @default.
• W2987174920 hasConceptScore W2987174920C70721500 @default.

• next