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- W2987187812 abstract "Cardiovascular (CV) diseases are the most common health problems worldwide, with a permanent increase in incidence. Growing evidence underlines that insulin-like growth factor 1 (IGF-1) is a very important hormone responsible for normal CV system physiology. IGF-1 is an anabolic growth hormone, responsible for cell growth, differentiation, proliferation, and survival. Despite systemic effects, IGF-1 exerts a wide array of influences in the CV system affecting metabolic homeostasis, vasorelaxation, cardiac contractility and hypertrophy, autophagy, apoptosis, and antioxidative processes. The vasodilatory effect of IGF-1, is achieved through the regulation of the activity of endothelial nitric oxide synthase (eNOS) and, at least partly, through enhancing inducible NOS (iNOS) activity. Also, IGF-1 stimulates vascular relaxation through regulation of sodium/potassiumadenosine- triphosphatase. Numerous animal studies provided evidence of diverse influences of IGF-1 in the CV system such as vasorelaxation, anti-apoptotic and prosurvival effects. Human studies indicate that low serum levels of free or total IGF-1 contribute to an increased risk of CV and cerebrovascular disease. Large human trials aiming at finding clinical efficacy and outcome of IGF-1-related therapy are of great interest. We look forward to the development of new IGF 1 therapies with minor side effects. In this review, we discuss the latest literature data regarding the function of IGF-1 in the CV system in the physiological and pathophysiological conditions." @default.
- W2987187812 created "2019-11-22" @default.
- W2987187812 creator A5017148360 @default.
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- W2987187812 creator A5051146926 @default.
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- W2987187812 creator A5090318561 @default.
- W2987187812 date "2019-12-11" @default.
- W2987187812 modified "2023-09-28" @default.
- W2987187812 title "Effects of IGF-1 on the Cardiovascular System" @default.
- W2987187812 cites W1488424161 @default.
- W2987187812 cites W1513391734 @default.
- W2987187812 cites W1551967741 @default.
- W2987187812 cites W1591165395 @default.
- W2987187812 cites W167582018 @default.
- W2987187812 cites W1754505974 @default.
- W2987187812 cites W1783515128 @default.
- W2987187812 cites W1835553983 @default.
- W2987187812 cites W1952816788 @default.
- W2987187812 cites W1963513641 @default.
- W2987187812 cites W1966187427 @default.
- W2987187812 cites W1970754801 @default.
- W2987187812 cites W1971028533 @default.
- W2987187812 cites W1972624341 @default.
- W2987187812 cites W1975454942 @default.
- W2987187812 cites W1975467688 @default.
- W2987187812 cites W1979677540 @default.
- W2987187812 cites W1984748893 @default.
- W2987187812 cites W1987378051 @default.
- W2987187812 cites W1995992086 @default.
- W2987187812 cites W1997146974 @default.
- W2987187812 cites W1999281645 @default.
- W2987187812 cites W2002120032 @default.
- W2987187812 cites W2004690081 @default.
- W2987187812 cites W2010399667 @default.
- W2987187812 cites W2010615112 @default.
- W2987187812 cites W2011449660 @default.
- W2987187812 cites W2012907081 @default.
- W2987187812 cites W2013040235 @default.
- W2987187812 cites W2014569485 @default.
- W2987187812 cites W2017207516 @default.
- W2987187812 cites W2017520143 @default.
- W2987187812 cites W2018830451 @default.
- W2987187812 cites W2024537012 @default.
- W2987187812 cites W2027784532 @default.
- W2987187812 cites W2028933014 @default.
- W2987187812 cites W2032848165 @default.
- W2987187812 cites W2033011007 @default.
- W2987187812 cites W2033420871 @default.
- W2987187812 cites W2034234987 @default.
- W2987187812 cites W2040427574 @default.
- W2987187812 cites W2042150160 @default.
- W2987187812 cites W2043692755 @default.
- W2987187812 cites W2050565531 @default.
- W2987187812 cites W2051040739 @default.
- W2987187812 cites W2051789726 @default.
- W2987187812 cites W2054021842 @default.
- W2987187812 cites W2057270626 @default.
- W2987187812 cites W2058720714 @default.
- W2987187812 cites W2061344163 @default.
- W2987187812 cites W2063567825 @default.
- W2987187812 cites W2065830159 @default.
- W2987187812 cites W2067984644 @default.
- W2987187812 cites W2068859480 @default.
- W2987187812 cites W2069035046 @default.
- W2987187812 cites W2069869036 @default.
- W2987187812 cites W2072667441 @default.
- W2987187812 cites W2076186944 @default.
- W2987187812 cites W2083807723 @default.
- W2987187812 cites W2084490045 @default.
- W2987187812 cites W2087061858 @default.
- W2987187812 cites W2087457070 @default.
- W2987187812 cites W2088723641 @default.
- W2987187812 cites W2088786418 @default.
- W2987187812 cites W2093065996 @default.
- W2987187812 cites W2100509042 @default.
- W2987187812 cites W2104744177 @default.
- W2987187812 cites W2105111757 @default.
- W2987187812 cites W2108928659 @default.
- W2987187812 cites W2111154780 @default.
- W2987187812 cites W2111980604 @default.
- W2987187812 cites W2114549166 @default.
- W2987187812 cites W2115292334 @default.
- W2987187812 cites W2115525455 @default.
- W2987187812 cites W2116667120 @default.
- W2987187812 cites W2121020585 @default.
- W2987187812 cites W2121408705 @default.
- W2987187812 cites W2128667978 @default.
- W2987187812 cites W2128911266 @default.
- W2987187812 cites W2130052411 @default.
- W2987187812 cites W2133132838 @default.
- W2987187812 cites W2133836273 @default.
- W2987187812 cites W2133867913 @default.
- W2987187812 cites W2133870378 @default.
- W2987187812 cites W2135276220 @default.
- W2987187812 cites W2138032600 @default.