FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2987197834> ?p ?o ?g. }

• W2987197834 endingPage "1225" @default.
• W2987197834 startingPage "1216" @default.
• W2987197834 abstract "Albumin binding is the major cause for the toxicity of protein bound uremic toxins (PBUTs) in uremic patients. Albumin binding property is exploited to address this issue, as some of the extracorporeal dialysis systems use albumin as dialysate. In this line, a detailed study about binding of PBUTs to human serum albumin (HSA) and its domains gives valuable information. The focus of this work emphasizes the mechanism of binding of HSA and its domains with a few selected PBUTs such as hippuric acid (HA), indole acetic acid (IAA) and melatonin. The HSA domains (D2, D3 and D2–3) were expressed in Pichia pastoris and purified by using Albupure matrix. The binding of the expressed domains and HSA, with PBUTs, was measured using surface plasmon resonance and analyzed. All the three domains have significant affinity towards PBUTs, while D3 had greater affinity for all the three selected PBUTs. Docking studies showed that the basic amino acid, lysine, was forming hydrogen bond with PUBTs inorder to stabile these complex. This study would be having therapeutic importance for preparing the extracorporeal dialysis systems, in combination of different domains of HSA to remove the PBUTs." @default.
• W2987197834 created "2019-11-22" @default.
• W2987197834 creator A5009636609 @default.
• W2987197834 creator A5009796178 @default.
• W2987197834 creator A5036770520 @default.
• W2987197834 creator A5077113916 @default.
• W2987197834 creator A5090463612 @default.
• W2987197834 date "2020-07-01" @default.
• W2987197834 modified "2023-10-17" @default.
• W2987197834 title "Truncated domains of human serum albumin improves the binding efficiency of uremic toxins: A surface plasmon resonance and computational approach" @default.
• W2987197834 cites W1518752203 @default.
• W2987197834 cites W1940950303 @default.
• W2987197834 cites W1954882272 @default.
• W2987197834 cites W1964200863 @default.
• W2987197834 cites W1965793914 @default.
• W2987197834 cites W1973238993 @default.
• W2987197834 cites W1975586699 @default.
• W2987197834 cites W1982267707 @default.
• W2987197834 cites W1988240997 @default.
• W2987197834 cites W1995666127 @default.
• W2987197834 cites W1996484588 @default.
• W2987197834 cites W2003442606 @default.
• W2987197834 cites W2004006450 @default.
• W2987197834 cites W2015206392 @default.
• W2987197834 cites W2016401253 @default.
• W2987197834 cites W2017654147 @default.
• W2987197834 cites W2018053812 @default.
• W2987197834 cites W2026830425 @default.
• W2987197834 cites W2030342919 @default.
• W2987197834 cites W2035240741 @default.
• W2987197834 cites W2040656960 @default.
• W2987197834 cites W2046231111 @default.
• W2987197834 cites W2046749537 @default.
• W2987197834 cites W2052720632 @default.
• W2987197834 cites W2053128592 @default.
• W2987197834 cites W2053696590 @default.
• W2987197834 cites W2053857618 @default.
• W2987197834 cites W2058399710 @default.
• W2987197834 cites W2059654186 @default.
• W2987197834 cites W2065954013 @default.
• W2987197834 cites W2078707812 @default.
• W2987197834 cites W2078923880 @default.
• W2987197834 cites W2083480064 @default.
• W2987197834 cites W2086075183 @default.
• W2987197834 cites W2088900329 @default.
• W2987197834 cites W2091749136 @default.
• W2987197834 cites W2104571730 @default.
• W2987197834 cites W2108986117 @default.
• W2987197834 cites W2118785002 @default.
• W2987197834 cites W2122231873 @default.
• W2987197834 cites W2124050480 @default.
• W2987197834 cites W2145073188 @default.
• W2987197834 cites W2147940704 @default.
• W2987197834 cites W2161969401 @default.
• W2987197834 cites W2164649676 @default.
• W2987197834 cites W2287645939 @default.
• W2987197834 cites W2324079694 @default.
• W2987197834 cites W2328396575 @default.
• W2987197834 cites W2764169630 @default.
• W2987197834 cites W2764275022 @default.
• W2987197834 doi "https://doi.org/10.1016/j.ijbiomac.2019.11.089" @default.
• W2987197834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31734369" @default.
• W2987197834 hasPublicationYear "2020" @default.
• W2987197834 type Work @default.
• W2987197834 sameAs 2987197834 @default.
• W2987197834 citedByCount "4" @default.
• W2987197834 countsByYear W29871978342021 @default.
• W2987197834 countsByYear W29871978342022 @default.
• W2987197834 countsByYear W29871978342023 @default.
• W2987197834 crossrefType "journal-article" @default.
• W2987197834 hasAuthorship W2987197834A5009636609 @default.
• W2987197834 hasAuthorship W2987197834A5009796178 @default.
• W2987197834 hasAuthorship W2987197834A5036770520 @default.
• W2987197834 hasAuthorship W2987197834A5077113916 @default.
• W2987197834 hasAuthorship W2987197834A5090463612 @default.
• W2987197834 hasConcept C106847996 @default.
• W2987197834 hasConcept C107824862 @default.
• W2987197834 hasConcept C155672457 @default.
• W2987197834 hasConcept C159110408 @default.
• W2987197834 hasConcept C165616093 @default.
• W2987197834 hasConcept C171250308 @default.
• W2987197834 hasConcept C185592680 @default.
• W2987197834 hasConcept C192562407 @default.
• W2987197834 hasConcept C2776125364 @default.
• W2987197834 hasConcept C2776706248 @default.
• W2987197834 hasConcept C2778597219 @default.
• W2987197834 hasConcept C2780026642 @default.
• W2987197834 hasConcept C2780548424 @default.
• W2987197834 hasConcept C41685203 @default.
• W2987197834 hasConcept C515207424 @default.
• W2987197834 hasConcept C51639874 @default.
• W2987197834 hasConcept C55493867 @default.
• W2987197834 hasConcept C71924100 @default.
• W2987197834 hasConcept C86807702 @default.
• W2987197834 hasConceptScore W2987197834C106847996 @default.
• W2987197834 hasConceptScore W2987197834C107824862 @default.
• W2987197834 hasConceptScore W2987197834C155672457 @default.
• W2987197834 hasConceptScore W2987197834C159110408 @default.

• next