Matches in SemOpenAlex for { <https://semopenalex.org/work/W2987284967> ?p ?o ?g. }
- W2987284967 abstract "Abstract Aim Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy resistance. The present study aimed to summarize the role of hypoxia in cancer therapy by regulating the tumor microenvironment (TME) and to highlight the potential of hypoxia-targeted therapy. Methods Relevant published studies were retrieved from PubMed, Web of Science, and Embase using keywords such as hypoxia, cancer therapy, resistance, TME, cancer, apoptosis, DNA damage, autophagy, p53, and other similar terms. Results Recent studies have shown that hypoxia is associated with poor prognosis in patients by regulating the TME. It confers resistance to conventional therapies through a number of signaling pathways in apoptosis, autophagy, DNA damage, mitochondrial activity, p53, and drug efflux. Conclusion Hypoxia targeting might be relevant to overcome hypoxia-associated resistance in cancer treatment." @default.
- W2987284967 created "2019-11-22" @default.
- W2987284967 creator A5014263686 @default.
- W2987284967 creator A5033921291 @default.
- W2987284967 creator A5066351423 @default.
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- W2987284967 creator A5074904959 @default.
- W2987284967 creator A5079097536 @default.
- W2987284967 creator A5085571166 @default.
- W2987284967 date "2019-11-11" @default.
- W2987284967 modified "2023-10-18" @default.
- W2987284967 title "Role of hypoxia in cancer therapy by regulating the tumor microenvironment" @default.
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