Matches in SemOpenAlex for { <https://semopenalex.org/work/W2987291710> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2987291710 abstract "Abstract A computational model is developed to study electrical propagation of vasodilatory signals and arteriolar regulation of blood flow depending on the oxygen tension and agonist distribution in capillary network. The involving key parameters of endothelial cell-to-cell electrical conductivity and plasma membrane area per unit volume were calibrated with the experimental data on an isolated endothelial tube of mouse skeletal feeding arteries. The oxygen saturation parameters in terms of ATP release from erythrocytes are estimated from the data of a left anterior descending coronary blood perfusion of dog. In regard to the acetylcholine induced upstream conduction, our model shows that spatially uniform superfusion of acetylcholine attenuates the electrical signal propagation, and blocking calcium activated potassium channels suppresses that attenuation. On the other hand, local infusion of acetylcholine induces enhanced electrical propagation that corresponds to physiological relevance. In the integration of the endothelial tube and the lumped arterioles vessel model, we show that endothelial purinergic oxygen sensing of ATP released from erythrocytes and local infusion of acetylcholine are all individually effective to induce vasodilatory signals to regulate blood flow in arterioles. We have recapitulated the upstream vasomotion in arterioles from the elevated oxygen tension in the downstream capillary domain. This study is a foundation for characterizing effective pharmaceutical strategies for ascending vasodilation and oxygenation." @default.
- W2987291710 created "2019-11-22" @default.
- W2987291710 creator A5003134797 @default.
- W2987291710 date "2019-11-13" @default.
- W2987291710 modified "2023-09-25" @default.
- W2987291710 title "Electrical propagation of vasodilatory signals in capillary networks" @default.
- W2987291710 cites W1224852380 @default.
- W2987291710 cites W1487735792 @default.
- W2987291710 cites W1513041539 @default.
- W2987291710 cites W1569090332 @default.
- W2987291710 cites W1863186034 @default.
- W2987291710 cites W1980874227 @default.
- W2987291710 cites W1982278691 @default.
- W2987291710 cites W1984179683 @default.
- W2987291710 cites W2016487986 @default.
- W2987291710 cites W2021724833 @default.
- W2987291710 cites W2024998621 @default.
- W2987291710 cites W2025644841 @default.
- W2987291710 cites W2032019404 @default.
- W2987291710 cites W2041609901 @default.
- W2987291710 cites W2041987144 @default.
- W2987291710 cites W2043697091 @default.
- W2987291710 cites W2044889656 @default.
- W2987291710 cites W2070851028 @default.
- W2987291710 cites W2073924708 @default.
- W2987291710 cites W2081056330 @default.
- W2987291710 cites W2102433198 @default.
- W2987291710 cites W2107941038 @default.
- W2987291710 cites W2108745939 @default.
- W2987291710 cites W2116602505 @default.
- W2987291710 cites W2117721152 @default.
- W2987291710 cites W2120016695 @default.
- W2987291710 cites W2122286457 @default.
- W2987291710 cites W2134256354 @default.
- W2987291710 cites W2145146752 @default.
- W2987291710 cites W2149085167 @default.
- W2987291710 cites W2155321653 @default.
- W2987291710 cites W2160368044 @default.
- W2987291710 cites W2163219993 @default.
- W2987291710 cites W2165938078 @default.
- W2987291710 cites W2168126615 @default.
- W2987291710 cites W2264322793 @default.
- W2987291710 cites W2332135198 @default.
- W2987291710 doi "https://doi.org/10.1101/840280" @default.
- W2987291710 hasPublicationYear "2019" @default.
- W2987291710 type Work @default.
- W2987291710 sameAs 2987291710 @default.
- W2987291710 citedByCount "0" @default.
- W2987291710 crossrefType "posted-content" @default.
- W2987291710 hasAuthorship W2987291710A5003134797 @default.
- W2987291710 hasBestOaLocation W29872917101 @default.
- W2987291710 hasConcept C120770815 @default.
- W2987291710 hasConcept C12554922 @default.
- W2987291710 hasConcept C126322002 @default.
- W2987291710 hasConcept C12722491 @default.
- W2987291710 hasConcept C185592680 @default.
- W2987291710 hasConcept C2775910092 @default.
- W2987291710 hasConcept C2777583614 @default.
- W2987291710 hasConcept C2779482390 @default.
- W2987291710 hasConcept C71924100 @default.
- W2987291710 hasConcept C86803240 @default.
- W2987291710 hasConceptScore W2987291710C120770815 @default.
- W2987291710 hasConceptScore W2987291710C12554922 @default.
- W2987291710 hasConceptScore W2987291710C126322002 @default.
- W2987291710 hasConceptScore W2987291710C12722491 @default.
- W2987291710 hasConceptScore W2987291710C185592680 @default.
- W2987291710 hasConceptScore W2987291710C2775910092 @default.
- W2987291710 hasConceptScore W2987291710C2777583614 @default.
- W2987291710 hasConceptScore W2987291710C2779482390 @default.
- W2987291710 hasConceptScore W2987291710C71924100 @default.
- W2987291710 hasConceptScore W2987291710C86803240 @default.
- W2987291710 hasLocation W29872917101 @default.
- W2987291710 hasOpenAccess W2987291710 @default.
- W2987291710 hasPrimaryLocation W29872917101 @default.
- W2987291710 hasRelatedWork W1568267272 @default.
- W2987291710 hasRelatedWork W1981774849 @default.
- W2987291710 hasRelatedWork W2015696723 @default.
- W2987291710 hasRelatedWork W2030537932 @default.
- W2987291710 hasRelatedWork W2035779422 @default.
- W2987291710 hasRelatedWork W2050523857 @default.
- W2987291710 hasRelatedWork W2056406931 @default.
- W2987291710 hasRelatedWork W2087968036 @default.
- W2987291710 hasRelatedWork W2115218292 @default.
- W2987291710 hasRelatedWork W2161075298 @default.
- W2987291710 hasRelatedWork W2288937776 @default.
- W2987291710 hasRelatedWork W2300459209 @default.
- W2987291710 hasRelatedWork W2380741844 @default.
- W2987291710 hasRelatedWork W2405099285 @default.
- W2987291710 hasRelatedWork W2753846428 @default.
- W2987291710 hasRelatedWork W2805177944 @default.
- W2987291710 hasRelatedWork W3091832293 @default.
- W2987291710 hasRelatedWork W3153326289 @default.
- W2987291710 hasRelatedWork W3174297363 @default.
- W2987291710 hasRelatedWork W2074199882 @default.
- W2987291710 isParatext "false" @default.
- W2987291710 isRetracted "false" @default.
- W2987291710 magId "2987291710" @default.
- W2987291710 workType "article" @default.