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- W2987306739 abstract "The Arctic fungus Eutypella sp. D-1, previously found to produce a variety of cytotoxic cyclopropyl-fused and cyclobutyl-fused pimarane diterpenoids when grown in the defined medium, was induced to produce unusual metabolites by growing on solid rice medium. A chemical investigation on the rice medium extract led to the isolation of four new meroterpenoids, eutypellacytosporins A–D (1–4), along with the known biogenetically related compound cytosporin D (5). The structures of the new compounds were elucidated by their detailed spectroscopic analysis and modified Mosher’s method. Compounds 1–4 may be formed by the 12,32-ester linkage of two moieties, cytosporin D (5) and decipienolide A or B. All isolated compounds, except 5, showed weak cytotoxicity against DU145, SW1990, Huh7, and PANC-1 cell lines with IC50 values ranging from 4.9 to 17.1 μM." @default.
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- W2987306739 date "2019-11-08" @default.
- W2987306739 modified "2023-10-16" @default.
- W2987306739 title "Eutypellacytosporins A–D, Meroterpenoids from the Arctic Fungus <i>Eutypella</i> sp. D-1" @default.
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- W2987306739 doi "https://doi.org/10.1021/acs.jnatprod.9b00700" @default.
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