FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2987326625> ?p ?o ?g. }

• W2987326625 abstract "The development of multidrug resistance (MDR) has seriously impeded the efficacy of drug treatment of chronic myeloid leukemia (CML). Recent studies have indicated that S100 calcium‑binding protein A8 (S100A8) is associated with the occurrence and development of MDR. Traditional Chinese medicine may provide drugs with the potential to be used as multidrug resistance reversal agents with low toxicity and multi‑target characteristics. The present study selected K562/DOX cells, a CML drug‑resistant cell line, as a research model, and aimed to examine whether curcumin was able to reverse the resistance to doxorubicin (DOX), and elucidate the underlying molecular mechanisms. An MTT cytotoxicity assay indicated that curcumin at 0.5‑2 µM reversed DOX resistance with a reversal index of 1.3‑9.3. Western blot analysis revealed that curcumin treatment caused a downregulation of the expression of P‑glycoprotein (P‑gp) and S100A8 in a dose‑ and time‑dependent manner. To study the internal association between S100A8 and P‑gp, and the S100A8 role in drug resistance reversal, an RNA knockdown assay was conducted; however, S100A8 did not regulate the expression of P‑gp or vice versa. After inhibiting the expression of S100A8 with specific small interfering RNA (si‑S100A8), the sensitivity of K562/DOX cells to DOX was enhanced. In addition, si‑S100A8 did not increase the intracellular accumulation of DOX, but increased the intracellular free calcium ion content, and the expression and activity of apoptosis‑associated proteins, thereby inducing apoptosis. In conclusion, the present study suggested that inhibition of S100A8 expression increased DOX‑induced apoptosis, and curcumin acted independently on S100A8 and P‑gp to exert its drug resistance reversal effects." @default.
• W2987326625 created "2019-11-22" @default.
• W2987326625 creator A5001300435 @default.
• W2987326625 creator A5019595634 @default.
• W2987326625 creator A5045874942 @default.
• W2987326625 creator A5086900951 @default.
• W2987326625 date "2019-11-13" @default.
• W2987326625 modified "2023-09-28" @default.
• W2987326625 title "Curcumin increases the sensitivity of K562/DOX cells to doxorubicin by targeting S100 calcium‑binding protein A8 and P‑glycoprotein" @default.
• W2987326625 cites W1545285984 @default.
• W2987326625 cites W1964951456 @default.
• W2987326625 cites W1972179974 @default.
• W2987326625 cites W1977672095 @default.
• W2987326625 cites W1979145183 @default.
• W2987326625 cites W1980931112 @default.
• W2987326625 cites W1981072770 @default.
• W2987326625 cites W1989323482 @default.
• W2987326625 cites W1999594247 @default.
• W2987326625 cites W2000353551 @default.
• W2987326625 cites W2001566658 @default.
• W2987326625 cites W2002439304 @default.
• W2987326625 cites W2010243889 @default.
• W2987326625 cites W2015996393 @default.
• W2987326625 cites W2022297793 @default.
• W2987326625 cites W2023019884 @default.
• W2987326625 cites W2032565254 @default.
• W2987326625 cites W2036145275 @default.
• W2987326625 cites W2045629975 @default.
• W2987326625 cites W2054767580 @default.
• W2987326625 cites W2057793836 @default.
• W2987326625 cites W2061443158 @default.
• W2987326625 cites W2062029885 @default.
• W2987326625 cites W2063483498 @default.
• W2987326625 cites W2064200041 @default.
• W2987326625 cites W2069668312 @default.
• W2987326625 cites W2072421347 @default.
• W2987326625 cites W2091597277 @default.
• W2987326625 cites W2100465045 @default.
• W2987326625 cites W2104182362 @default.
• W2987326625 cites W2107922803 @default.
• W2987326625 cites W2115494253 @default.
• W2987326625 cites W2125961046 @default.
• W2987326625 cites W2131349383 @default.
• W2987326625 cites W2132940659 @default.
• W2987326625 cites W2133614237 @default.
• W2987326625 cites W2143494947 @default.
• W2987326625 cites W2143626453 @default.
• W2987326625 cites W2157894448 @default.
• W2987326625 cites W2192095672 @default.
• W2987326625 cites W2308408790 @default.
• W2987326625 cites W2517883814 @default.
• W2987326625 cites W2518885026 @default.
• W2987326625 cites W2547930084 @default.
• W2987326625 cites W2587496999 @default.
• W2987326625 cites W2604154469 @default.
• W2987326625 cites W2730689048 @default.
• W2987326625 cites W2738413581 @default.
• W2987326625 cites W2767410966 @default.
• W2987326625 cites W2782601539 @default.
• W2987326625 cites W2796552195 @default.
• W2987326625 cites W2806693786 @default.
• W2987326625 cites W2807073560 @default.
• W2987326625 cites W2861982167 @default.
• W2987326625 cites W2888846303 @default.
• W2987326625 cites W3025968138 @default.
• W2987326625 cites W4255760236 @default.
• W2987326625 doi "https://doi.org/10.3892/ol.2019.11083" @default.
• W2987326625 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6924120" @default.
• W2987326625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31897118" @default.
• W2987326625 hasPublicationYear "2019" @default.
• W2987326625 type Work @default.
• W2987326625 sameAs 2987326625 @default.
• W2987326625 citedByCount "12" @default.
• W2987326625 countsByYear W29873266252020 @default.
• W2987326625 countsByYear W29873266252021 @default.
• W2987326625 countsByYear W29873266252022 @default.
• W2987326625 countsByYear W29873266252023 @default.
• W2987326625 crossrefType "journal-article" @default.
• W2987326625 hasAuthorship W2987326625A5001300435 @default.
• W2987326625 hasAuthorship W2987326625A5019595634 @default.
• W2987326625 hasAuthorship W2987326625A5045874942 @default.
• W2987326625 hasAuthorship W2987326625A5086900951 @default.
• W2987326625 hasBestOaLocation W29873266251 @default.
• W2987326625 hasConcept C104317684 @default.
• W2987326625 hasConcept C109316439 @default.
• W2987326625 hasConcept C114851261 @default.
• W2987326625 hasConcept C127561419 @default.
• W2987326625 hasConcept C133936738 @default.
• W2987326625 hasConcept C153911025 @default.
• W2987326625 hasConcept C171122931 @default.
• W2987326625 hasConcept C173396325 @default.
• W2987326625 hasConcept C185592680 @default.
• W2987326625 hasConcept C190283241 @default.
• W2987326625 hasConcept C202751555 @default.
• W2987326625 hasConcept C22615655 @default.
• W2987326625 hasConcept C2776694085 @default.
• W2987326625 hasConcept C2778250585 @default.
• W2987326625 hasConcept C2778557267 @default.
• W2987326625 hasConcept C2778707650 @default.
• W2987326625 hasConcept C2780783641 @default.

• next