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- W2987360672 abstract "Abstract Understanding the mechanisms underlying the selective susceptibility to ischemia of the CA3 region is very important to explain the neuropathology of memory loss after brain ischemia. We used a rat model to study changes in gene expression of the amyloid protein precursor and its cleaving enzymes and tau protein in the hippocampal CA3 sector, after transient 10-min global brain ischemia with survival times of 2, 7, and 30 days. The expression of the α-secretase gene was below control values at all times studied. But, the expression of the β-secretase gene was below the control values at 2–7 days after ischemia and the maximal increase in its expression was observed on day 30. Expression of the presenilin 1 gene was significantly elevated above the control values at 2–7 days after ischemia and decreased below the control values at day 30. Expression of the presenilin 2 gene showed an opposite trend to the expression of presenilin 1. Expression of the amyloid protein precursor gene after ischemia was at all times above the control values with a huge significant overexpression on day 7. Additionally, the expression of the tau protein gene was below the control values 2 days after ischemia, but the significant increase in its expression was observed on days 7–30. Data show that brain ischemia activates neuronal changes and death in the CA3 region of the hippocampus in a manner dependent on amyloid and tau protein, thus determining a new and important way to regulate the survival and/or death of ischemic neurons." @default.
- W2987360672 created "2019-11-22" @default.
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- W2987360672 date "2019-11-12" @default.
- W2987360672 modified "2023-09-27" @default.
- W2987360672 title "Expression of the Tau Protein and Amyloid Protein Precursor Processing Genes in the CA3 Area of the Hippocampus in the Ischemic Model of Alzheimer’s Disease in the Rat" @default.
- W2987360672 cites W1529927626 @default.
- W2987360672 cites W1549697295 @default.
- W2987360672 cites W1687509216 @default.
- W2987360672 cites W1822669487 @default.
- W2987360672 cites W1968578618 @default.
- W2987360672 cites W1970692524 @default.
- W2987360672 cites W1971129331 @default.
- W2987360672 cites W1976572274 @default.
- W2987360672 cites W1979388710 @default.
- W2987360672 cites W1983711535 @default.
- W2987360672 cites W1983920882 @default.
- W2987360672 cites W1984611452 @default.
- W2987360672 cites W1999625786 @default.
- W2987360672 cites W2004908879 @default.
- W2987360672 cites W2004984841 @default.
- W2987360672 cites W2008909874 @default.
- W2987360672 cites W2015199350 @default.
- W2987360672 cites W2021598280 @default.
- W2987360672 cites W2022305760 @default.
- W2987360672 cites W2022380909 @default.
- W2987360672 cites W2024590722 @default.
- W2987360672 cites W2026814715 @default.
- W2987360672 cites W2036450484 @default.
- W2987360672 cites W2038532164 @default.
- W2987360672 cites W2043206977 @default.
- W2987360672 cites W2046759860 @default.
- W2987360672 cites W2051003620 @default.
- W2987360672 cites W2052697605 @default.
- W2987360672 cites W2055751916 @default.
- W2987360672 cites W2061981764 @default.
- W2987360672 cites W2064177315 @default.
- W2987360672 cites W2077935628 @default.
- W2987360672 cites W2085059773 @default.
- W2987360672 cites W2087810518 @default.
- W2987360672 cites W2091868567 @default.
- W2987360672 cites W2103273331 @default.
- W2987360672 cites W2107277218 @default.
- W2987360672 cites W2108677329 @default.
- W2987360672 cites W2116876598 @default.
- W2987360672 cites W2130824857 @default.
- W2987360672 cites W2134812217 @default.
- W2987360672 cites W2138088365 @default.
- W2987360672 cites W2153663044 @default.
- W2987360672 cites W2164735970 @default.
- W2987360672 cites W2188997093 @default.
- W2987360672 cites W2192080449 @default.
- W2987360672 cites W2275525717 @default.
- W2987360672 cites W2284799363 @default.
- W2987360672 cites W2294484379 @default.
- W2987360672 cites W2314401977 @default.
- W2987360672 cites W2389314332 @default.
- W2987360672 cites W2396298713 @default.
- W2987360672 cites W2414995882 @default.
- W2987360672 cites W2441959335 @default.
- W2987360672 cites W2495288752 @default.
- W2987360672 cites W2520224148 @default.
- W2987360672 cites W2567096679 @default.
- W2987360672 cites W2591936998 @default.
- W2987360672 cites W2592291074 @default.
- W2987360672 cites W2601932596 @default.
- W2987360672 cites W2735792123 @default.
- W2987360672 cites W2751298713 @default.
- W2987360672 cites W2792501226 @default.
- W2987360672 cites W2796472971 @default.
- W2987360672 cites W2800599194 @default.
- W2987360672 cites W2801384630 @default.
- W2987360672 cites W2892268684 @default.
- W2987360672 cites W2892685649 @default.
- W2987360672 cites W2899689462 @default.
- W2987360672 cites W2914745822 @default.
- W2987360672 cites W2979847465 @default.
- W2987360672 cites W35269786 @default.
- W2987360672 cites W4246364355 @default.
- W2987360672 cites W4294216491 @default.
- W2987360672 cites W4378610318 @default.
- W2987360672 cites W47694475 @default.
- W2987360672 cites W84489083 @default.
- W2987360672 cites W946224832 @default.
- W2987360672 cites W96277011 @default.
- W2987360672 doi "https://doi.org/10.1007/s12035-019-01799-z" @default.
- W2987360672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7031177" @default.
- W2987360672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31713815" @default.
- W2987360672 hasPublicationYear "2019" @default.
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