Matches in SemOpenAlex for { <https://semopenalex.org/work/W2987362023> ?p ?o ?g. }
- W2987362023 endingPage "250.e8" @default.
- W2987362023 startingPage "241" @default.
- W2987362023 abstract "The signal recognition particle (SRP), responsible for co-translational protein targeting and delivery to cellular membranes, depends on the native long-hairpin fold of its RNA to confer functionality. Since RNA initiates folding during its synthesis, we used high-resolution optical tweezers to follow in real time the co-transcriptional folding of SRP RNA. Surprisingly, SRP RNA folding is robust to transcription rate changes and the presence or absence of its 5'-precursor sequence. The folding pathway also reveals the obligatory attainment of a non-native hairpin intermediate (H1) that eventually rearranges into the native fold. Furthermore, H1 provides a structural platform alternative to the native fold for RNase P to bind and mature SRP RNA co-transcriptionally. Delays in attaining the final native fold are detrimental to the cell, altogether showing that a co-transcriptional folding pathway underpins the proper biogenesis of function-essential SRP RNA." @default.
- W2987362023 created "2019-11-22" @default.
- W2987362023 creator A5007647025 @default.
- W2987362023 creator A5010743284 @default.
- W2987362023 creator A5014664746 @default.
- W2987362023 creator A5024954997 @default.
- W2987362023 creator A5043687273 @default.
- W2987362023 creator A5091830780 @default.
- W2987362023 date "2020-01-01" @default.
- W2987362023 modified "2023-10-15" @default.
- W2987362023 title "The Biogenesis of SRP RNA Is Modulated by an RNA Folding Intermediate Attained during Transcription" @default.
- W2987362023 cites W110087793 @default.
- W2987362023 cites W1490955408 @default.
- W2987362023 cites W1514207700 @default.
- W2987362023 cites W1550782287 @default.
- W2987362023 cites W1572494942 @default.
- W2987362023 cites W196616756 @default.
- W2987362023 cites W1966919808 @default.
- W2987362023 cites W1970103400 @default.
- W2987362023 cites W1979197349 @default.
- W2987362023 cites W1980301976 @default.
- W2987362023 cites W1983010859 @default.
- W2987362023 cites W1986067700 @default.
- W2987362023 cites W1988205757 @default.
- W2987362023 cites W1990245422 @default.
- W2987362023 cites W1992263711 @default.
- W2987362023 cites W1997368981 @default.
- W2987362023 cites W2022096556 @default.
- W2987362023 cites W2022310029 @default.
- W2987362023 cites W2024080095 @default.
- W2987362023 cites W2028243446 @default.
- W2987362023 cites W2029150001 @default.
- W2987362023 cites W2032446389 @default.
- W2987362023 cites W2036475903 @default.
- W2987362023 cites W2042001563 @default.
- W2987362023 cites W2042070371 @default.
- W2987362023 cites W2042987116 @default.
- W2987362023 cites W2067947421 @default.
- W2987362023 cites W2068146975 @default.
- W2987362023 cites W2075601360 @default.
- W2987362023 cites W2087581187 @default.
- W2987362023 cites W2091343095 @default.
- W2987362023 cites W2092043019 @default.
- W2987362023 cites W2092792860 @default.
- W2987362023 cites W2092867032 @default.
- W2987362023 cites W2094507358 @default.
- W2987362023 cites W2102506763 @default.
- W2987362023 cites W2133968430 @default.
- W2987362023 cites W2137032962 @default.
- W2987362023 cites W2138438888 @default.
- W2987362023 cites W2140435480 @default.
- W2987362023 cites W2145747826 @default.
- W2987362023 cites W2146841180 @default.
- W2987362023 cites W2148575508 @default.
- W2987362023 cites W2148641266 @default.
- W2987362023 cites W2152002881 @default.
- W2987362023 cites W2152466935 @default.
- W2987362023 cites W2160445124 @default.
- W2987362023 cites W2170813053 @default.
- W2987362023 cites W2252113956 @default.
- W2987362023 cites W2588569080 @default.
- W2987362023 cites W2784066815 @default.
- W2987362023 cites W2883967095 @default.
- W2987362023 cites W2952381529 @default.
- W2987362023 cites W4236305042 @default.
- W2987362023 cites W46085118 @default.
- W2987362023 doi "https://doi.org/10.1016/j.molcel.2019.10.006" @default.
- W2987362023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31706702" @default.
- W2987362023 hasPublicationYear "2020" @default.
- W2987362023 type Work @default.
- W2987362023 sameAs 2987362023 @default.
- W2987362023 citedByCount "17" @default.
- W2987362023 countsByYear W29873620232021 @default.
- W2987362023 countsByYear W29873620232022 @default.
- W2987362023 countsByYear W29873620232023 @default.
- W2987362023 crossrefType "journal-article" @default.
- W2987362023 hasAuthorship W2987362023A5007647025 @default.
- W2987362023 hasAuthorship W2987362023A5010743284 @default.
- W2987362023 hasAuthorship W2987362023A5014664746 @default.
- W2987362023 hasAuthorship W2987362023A5024954997 @default.
- W2987362023 hasAuthorship W2987362023A5043687273 @default.
- W2987362023 hasAuthorship W2987362023A5091830780 @default.
- W2987362023 hasBestOaLocation W29873620231 @default.
- W2987362023 hasConcept C104317684 @default.
- W2987362023 hasConcept C10879258 @default.
- W2987362023 hasConcept C12554922 @default.
- W2987362023 hasConcept C131934819 @default.
- W2987362023 hasConcept C138885662 @default.
- W2987362023 hasConcept C172827444 @default.
- W2987362023 hasConcept C179926584 @default.
- W2987362023 hasConcept C186175293 @default.
- W2987362023 hasConcept C194993378 @default.
- W2987362023 hasConcept C36457064 @default.
- W2987362023 hasConcept C41282012 @default.
- W2987362023 hasConcept C41895202 @default.
- W2987362023 hasConcept C55493867 @default.
- W2987362023 hasConcept C67705224 @default.
- W2987362023 hasConcept C86803240 @default.