FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2987364071> ?p ?o ?g. }

• W2987364071 endingPage "39" @default.
• W2987364071 startingPage "30" @default.
• W2987364071 abstract "To examine whether genetic variation affecting the expression or function of lipid-lowering drug targets is associated with Alzheimer disease (AD) risk, to evaluate the potential impact of long-term exposure to corresponding therapeutics.We conducted Mendelian randomization analyses using variants in genes that encode the protein targets of several approved lipid-lowering drug classes: HMGCR (encoding the target for statins), PCSK9 (encoding the target for PCSK9 inhibitors, eg, evolocumab and alirocumab), NPC1L1 (encoding the target for ezetimibe), and APOB (encoding the target of mipomersen). Variants were weighted by associations with low-density lipoprotein cholesterol (LDL-C) using data from lipid genetics consortia (n up to 295,826). We meta-analyzed Mendelian randomization estimates for regional variants weighted by LDL-C on AD risk from 2 large samples (total n = 24,718 cases, 56,685 controls).Models for HMGCR, APOB, and NPC1L1 did not suggest that the use of related lipid-lowering drug classes would affect AD risk. In contrast, genetically instrumented exposure to PCSK9 inhibitors was predicted to increase AD risk in both of the AD samples (combined odds ratio per standard deviation lower LDL-C inducible by the drug target = 1.45, 95% confidence interval = 1.23-1.69). This risk increase was opposite to, although more modest than, the degree of protection from coronary artery disease predicted by these same methods for PCSK9 inhibition.We did not identify genetic support for the repurposing of statins, ezetimibe, or mipomersen for AD prevention. Notwithstanding caveats to this genetic evidence, pharmacovigilance for AD risk among users of PCSK9 inhibitors may be warranted. ANN NEUROL 2020;87:30-39." @default.
• W2987364071 created "2019-11-22" @default.
• W2987364071 creator A5016704551 @default.
• W2987364071 creator A5018148532 @default.
• W2987364071 creator A5081842404 @default.
• W2987364071 creator A5085267690 @default.
• W2987364071 creator A5087932701 @default.
• W2987364071 date "2019-12-13" @default.
• W2987364071 modified "2023-10-15" @default.
• W2987364071 title "Lipid lowering and Alzheimer disease risk: A mendelian randomization study" @default.
• W2987364071 cites W1530780272 @default.
• W2987364071 cites W1757841311 @default.
• W2987364071 cites W1905058580 @default.
• W2987364071 cites W1922625321 @default.
• W2987364071 cites W1972696558 @default.
• W2987364071 cites W1993023011 @default.
• W2987364071 cites W1996719014 @default.
• W2987364071 cites W2038304466 @default.
• W2987364071 cites W2038845402 @default.
• W2987364071 cites W2045017910 @default.
• W2987364071 cites W2047972989 @default.
• W2987364071 cites W2082429191 @default.
• W2987364071 cites W2083006110 @default.
• W2987364071 cites W2083625312 @default.
• W2987364071 cites W2084899590 @default.
• W2987364071 cites W2104549677 @default.
• W2987364071 cites W2112848098 @default.
• W2987364071 cites W2113699335 @default.
• W2987364071 cites W2118743532 @default.
• W2987364071 cites W2120070267 @default.
• W2987364071 cites W2144907160 @default.
• W2987364071 cites W2153118028 @default.
• W2987364071 cites W2175943040 @default.
• W2987364071 cites W2310542696 @default.
• W2987364071 cites W2324862792 @default.
• W2987364071 cites W2401811918 @default.
• W2987364071 cites W2462634178 @default.
• W2987364071 cites W2463641243 @default.
• W2987364071 cites W2528302205 @default.
• W2987364071 cites W2529053508 @default.
• W2987364071 cites W2559592043 @default.
• W2987364071 cites W2604218568 @default.
• W2987364071 cites W2607529696 @default.
• W2987364071 cites W2608642452 @default.
• W2987364071 cites W2724719188 @default.
• W2987364071 cites W2767038995 @default.
• W2987364071 cites W2769398456 @default.
• W2987364071 cites W2774720490 @default.
• W2987364071 cites W2784344699 @default.
• W2987364071 cites W2800766177 @default.
• W2987364071 cites W2805983714 @default.
• W2987364071 cites W2807752244 @default.
• W2987364071 cites W2811289319 @default.
• W2987364071 cites W2883840241 @default.
• W2987364071 cites W2908002252 @default.
• W2987364071 cites W2916749909 @default.
• W2987364071 cites W2995908837 @default.
• W2987364071 cites W605291159 @default.
• W2987364071 doi "https://doi.org/10.1002/ana.25642" @default.
• W2987364071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6944510" @default.
• W2987364071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31714636" @default.
• W2987364071 hasPublicationYear "2019" @default.
• W2987364071 type Work @default.
• W2987364071 sameAs 2987364071 @default.
• W2987364071 citedByCount "46" @default.
• W2987364071 countsByYear W29873640712020 @default.
• W2987364071 countsByYear W29873640712021 @default.
• W2987364071 countsByYear W29873640712022 @default.
• W2987364071 countsByYear W29873640712023 @default.
• W2987364071 crossrefType "journal-article" @default.
• W2987364071 hasAuthorship W2987364071A5016704551 @default.
• W2987364071 hasAuthorship W2987364071A5018148532 @default.
• W2987364071 hasAuthorship W2987364071A5081842404 @default.
• W2987364071 hasAuthorship W2987364071A5085267690 @default.
• W2987364071 hasAuthorship W2987364071A5087932701 @default.
• W2987364071 hasBestOaLocation W29873640711 @default.
• W2987364071 hasConcept C104317684 @default.
• W2987364071 hasConcept C126322002 @default.
• W2987364071 hasConcept C134018914 @default.
• W2987364071 hasConcept C135763542 @default.
• W2987364071 hasConcept C156957248 @default.
• W2987364071 hasConcept C2778163477 @default.
• W2987364071 hasConcept C2778657065 @default.
• W2987364071 hasConcept C2779901538 @default.
• W2987364071 hasConcept C2780072125 @default.
• W2987364071 hasConcept C2780948078 @default.
• W2987364071 hasConcept C2993967602 @default.
• W2987364071 hasConcept C43554185 @default.
• W2987364071 hasConcept C54355233 @default.
• W2987364071 hasConcept C60644358 @default.
• W2987364071 hasConcept C71924100 @default.
• W2987364071 hasConcept C86803240 @default.
• W2987364071 hasConcept C98274493 @default.
• W2987364071 hasConceptScore W2987364071C104317684 @default.
• W2987364071 hasConceptScore W2987364071C126322002 @default.
• W2987364071 hasConceptScore W2987364071C134018914 @default.
• W2987364071 hasConceptScore W2987364071C135763542 @default.
• W2987364071 hasConceptScore W2987364071C156957248 @default.

• next