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• W2987388410 endingPage "1054" @default.
• W2987388410 startingPage "1054" @default.
• W2987388410 abstract "Infectious bronchitis virus (IBV) infection in chickens can lead to an economically important disease, namely, infectious bronchitis (IB). New IBV variants are continuously emerging, which complicates vaccination-based IB control. In this study, five IBVs were isolated from clinical samples submitted to a diagnostic laboratory in Ontario, Canada, and subjected to detailed molecular characterization. Analysis of the spike (S)1 gene showed that these five IBVs were highly related to the Delmarva (DMV/1639) strain (~97.0% nucleotide sequence similarity) that was firstly isolated from an IB outbreak in the Delmarva peninsula, United States of America (USA), in 2011. However, the complete genomic sequence analysis showed a 93.5–93.7% similarity with the Connecticut (Conn) vaccine strain, suggesting that Conn-like viruses contributed to the evolution of the five Canadian IBV/DMV isolates. A SimPlot analysis of the complete genomic sequence showed evidence of recombination for at least three different IBV strains, including a Conn vaccine-like strain, a 4/91 vaccine-like strain, and one strain that is yet-unidentified. The unidentified strain may have contributed the genomic regions of the S, 3, and membrane (M) genes of the five Canadian IBV/DMV isolates. The study outcomes add to the existing knowledge about involvement of recombination in IBV evolution." @default.
• W2987388410 created "2019-11-22" @default.
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• W2987388410 date "2019-11-13" @default.
• W2987388410 modified "2023-09-26" @default.
• W2987388410 title "Delmarva (DMV/1639) Infectious Bronchitis Virus (IBV) Variants Isolated in Eastern Canada Show Evidence of Recombination" @default.
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• W2987388410 doi "https://doi.org/10.3390/v11111054" @default.
• W2987388410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6893544" @default.
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• W2987388410 hasPublicationYear "2019" @default.
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