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- W2987448992 endingPage "e17803" @default.
- W2987448992 startingPage "e17803" @default.
- W2987448992 abstract "High-grade serous ovarian carcinoma (HGSOC) is the most prevalent and malignant ovarian tumor.To identify co-expression modules and hub genes correlated with platinum-based chemotherapy resistant and sensitive HGSOC, we performed weighted gene co-expression network analysis (WGCNA) on microarray data of HGSOC with 12 resistant samples and 16 sensitive samples of GSE51373 dataset.A total of 5122 genes were included in WGCNA, and 16 modules were identified. Module-trait analysis identified that the module salmon (cor = 0.50), magenta (cor = 0.49), and black (cor = 0.45) were discovered associated with chemotherapy resistant, and the significance for these platinum-resistant modules were validated in the GSE63885 dataset. Given that the black module was validated to be the most related one, hub genes of this module, alcohol dehydrogenase 1B, cadherin 11, and vestigial like family member 3were revealed to be expressional related with platinum resistance, and could serve as prognostic markers for ovarian cancer.Our analysis might provide insight for molecular mechanisms of platinum-based chemotherapy resistance and treatment response in ovarian cancer." @default.
- W2987448992 created "2019-11-22" @default.
- W2987448992 creator A5020146209 @default.
- W2987448992 creator A5039791175 @default.
- W2987448992 creator A5045839676 @default.
- W2987448992 creator A5052937683 @default.
- W2987448992 date "2019-11-01" @default.
- W2987448992 modified "2023-10-12" @default.
- W2987448992 title "Identification of modules and hub genes associated with platinum-based chemotherapy resistance and treatment response in ovarian cancer by weighted gene co-expression network analysis" @default.
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