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- W2987457682 abstract "ALDENSTRUM in 1944 [ 73 described a disease entity which he later called macroglobulinemia [2]. Its characteristic features are: an increased erythrocyte sedimentation rate, hyperglobulinemia, and the presence in the serum of a macroglobulin of high molecular weight which can be demonstrated by ultracentrifugation. There may also be weakness, anemia, mucosal hemorrhages and skin ecchymoses, generalised swelling of lymph nodes, hepatosplenomegaly and, in most cases, infiltration of the bone marrow by lymphoid and plasma cells. In some of the cases cryoglobulins were found and jellification of the blood was noted at room temperature. Since WaldenstrGm described the first patient, about fifty cases have been described, mostly from Continental Europe [ 7-76,40,47,&]; four cases have been described in the United States [77,23,26], two in England [8,27] and one in Canada [38]. This case is the first from Israel and is of interest because of the finding of “grape cells” in the bone marrow in addition to the typical infiltration of the marrow with lymphoid cells. CASE REPORT" @default.
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- W2987457682 date "1958-01-01" @default.
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- W2987457682 title "Macroglobulinemia of Waldenstrijm" @default.
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