Matches in SemOpenAlex for { <https://semopenalex.org/work/W298746197> ?p ?o ?g. }
- W298746197 endingPage "13" @default.
- W298746197 startingPage "104" @default.
- W298746197 abstract "A correlation of the logarithmic values of the in vitro dissolution rate, G, and the apparent solubility, S, was evaluated in phosphate and ammonium acetate buffer at an initial pH of 7. The dissolution rates were determined with a newly designed and build miniaturized rotating disk equipment, as well as with a traditional rotating disk apparatus. The two apparatuses gave the same correlation pattern of logG and logS. Thirteen diverse drug substances from all of the classes in the Biopharmaceutics Classification System (BCS) were used for the correlation in the phosphate buffer system, with the results from the miniaturized apparatus only. A coefficient of determination, R2, of 0.982 was found if bases formulated as hydrochloride salts were excluded in the correlation. The miniaturized equipment is used for rapid screening of the dissolution rate, approximately 10 min for one run, and consumes small amounts of substance (about 5 mg) and dissolution media. All quantifications were performed by using reversed phase high-performance liquid chromatography (RPHPLC) with a diode array detector (DAD), integrated with the miniaturized rotating disk equipment." @default.
- W298746197 created "2016-06-24" @default.
- W298746197 creator A5024319019 @default.
- W298746197 creator A5043997542 @default.
- W298746197 creator A5048264333 @default.
- W298746197 date "2009-06-01" @default.
- W298746197 modified "2023-09-23" @default.
- W298746197 title "Correlation of in vitro dissolution rate and apparent solubility in buffered media using a miniaturized rotating disk equipment: Part I. Comparison with a traditional USP rotating disk apparatus." @default.
- W298746197 cites W121978488 @default.
- W298746197 cites W1499768710 @default.
- W298746197 cites W1522161842 @default.
- W298746197 cites W1522767714 @default.
- W298746197 cites W1859219301 @default.
- W298746197 cites W191227402 @default.
- W298746197 cites W1965585024 @default.
- W298746197 cites W1971892118 @default.
- W298746197 cites W1977201403 @default.
- W298746197 cites W1977750336 @default.
- W298746197 cites W1982862993 @default.
- W298746197 cites W1992010938 @default.
- W298746197 cites W1996636629 @default.
- W298746197 cites W1999371780 @default.
- W298746197 cites W2006465449 @default.
- W298746197 cites W2007367498 @default.
- W298746197 cites W2011044581 @default.
- W298746197 cites W2016623235 @default.
- W298746197 cites W2018285775 @default.
- W298746197 cites W2023871203 @default.
- W298746197 cites W2034205145 @default.
- W298746197 cites W2037821082 @default.
- W298746197 cites W2043009504 @default.
- W298746197 cites W2058415843 @default.
- W298746197 cites W2063319086 @default.
- W298746197 cites W2064612766 @default.
- W298746197 cites W2076802558 @default.
- W298746197 cites W2087677039 @default.
- W298746197 cites W2087909593 @default.
- W298746197 cites W2117277757 @default.
- W298746197 cites W2118017028 @default.
- W298746197 cites W2121444977 @default.
- W298746197 cites W2122768566 @default.
- W298746197 cites W2124084576 @default.
- W298746197 cites W2127361200 @default.
- W298746197 cites W2140417949 @default.
- W298746197 cites W2151520572 @default.
- W298746197 cites W2152049632 @default.
- W298746197 cites W2161551306 @default.
- W298746197 cites W2169388362 @default.
- W298746197 cites W2172178712 @default.
- W298746197 cites W2294484752 @default.
- W298746197 cites W2330097054 @default.
- W298746197 cites W289728766 @default.
- W298746197 cites W41378874 @default.
- W298746197 cites W560837695 @default.
- W298746197 cites W579508473 @default.
- W298746197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22495538" @default.
- W298746197 hasPublicationYear "2009" @default.
- W298746197 type Work @default.
- W298746197 sameAs 298746197 @default.
- W298746197 citedByCount "5" @default.
- W298746197 countsByYear W2987461972015 @default.
- W298746197 countsByYear W2987461972016 @default.
- W298746197 crossrefType "journal-article" @default.
- W298746197 hasAuthorship W298746197A5024319019 @default.
- W298746197 hasAuthorship W298746197A5043997542 @default.
- W298746197 hasAuthorship W298746197A5048264333 @default.
- W298746197 hasConcept C105795698 @default.
- W298746197 hasConcept C113196181 @default.
- W298746197 hasConcept C14029885 @default.
- W298746197 hasConcept C155574463 @default.
- W298746197 hasConcept C178790620 @default.
- W298746197 hasConcept C179998833 @default.
- W298746197 hasConcept C185592680 @default.
- W298746197 hasConcept C192562407 @default.
- W298746197 hasConcept C2780092901 @default.
- W298746197 hasConcept C2780782300 @default.
- W298746197 hasConcept C2781430271 @default.
- W298746197 hasConcept C33923547 @default.
- W298746197 hasConcept C43617362 @default.
- W298746197 hasConcept C88380143 @default.
- W298746197 hasConcept C96616956 @default.
- W298746197 hasConceptScore W298746197C105795698 @default.
- W298746197 hasConceptScore W298746197C113196181 @default.
- W298746197 hasConceptScore W298746197C14029885 @default.
- W298746197 hasConceptScore W298746197C155574463 @default.
- W298746197 hasConceptScore W298746197C178790620 @default.
- W298746197 hasConceptScore W298746197C179998833 @default.
- W298746197 hasConceptScore W298746197C185592680 @default.
- W298746197 hasConceptScore W298746197C192562407 @default.
- W298746197 hasConceptScore W298746197C2780092901 @default.
- W298746197 hasConceptScore W298746197C2780782300 @default.
- W298746197 hasConceptScore W298746197C2781430271 @default.
- W298746197 hasConceptScore W298746197C33923547 @default.
- W298746197 hasConceptScore W298746197C43617362 @default.
- W298746197 hasConceptScore W298746197C88380143 @default.
- W298746197 hasConceptScore W298746197C96616956 @default.
- W298746197 hasIssue "3" @default.
- W298746197 hasLocation W2987461971 @default.