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• W2987519005 abstract "본 연구는 혈당상승 및 당뇨병 질환 개선을 위한 주요 목표효소인 α-glucosidase에 대하여 콩 주요 기능성 성분인 isoflavone 및 soyasaponin 성분에 대한 저해 효능 평가를 살펴보았다. 실험에 사용된 22종류의 성분 중 isoflavone에서는 genistein 및 daidzein 성분이 α-glucosidase 억제 효능이 뛰어났으며, ICSUB50/SUB 값은 각각 8.8±2.6 및 13.7±2.5 μM로 양성 대조군인 acarbose(ICSUB50/SUB=620.2 μM)에 비해 각각 70배 및 45배 더 우수한 효과를 보였다. 또한 genistein 및 daidzein 성분은 α-glucosidase에 대해 비경쟁적 저해를 하는 것으로 분석되었으며, Dixon plot을 이용하여 저해와 관련한 상수 KSUBi/SUB 값은 10.1 및 14.5 μM로 분석되었다. 하지만 일반 콩 종실에 많이 함유된 malonyl기 계열 및 배당체 형태의 isoflavone들은 100 μM 농도에서 저해 효과가 없었다. 콩 soyasaponin 중에서는 그룹B 계열의 사포닌인 soyasaponin Ba, Bb 및 Bb" @default.
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• W2987519005 date "2019-09-30" @default.
• W2987519005 modified "2023-10-17" @default.
• W2987519005 title "α-Glucosidase Inhibitory Activity of Isoflavones and Saponins from Soybean (Glycine max L.) and Comparisons of Their Constituents during Heat Treatments" @default.
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• W2987519005 doi "https://doi.org/10.3746/jkfn.2019.48.9.953" @default.
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