Matches in SemOpenAlex for { <https://semopenalex.org/work/W2987537683> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2987537683 endingPage "13" @default.
- W2987537683 startingPage "1" @default.
- W2987537683 abstract "Colorectal cancer (CRC) is one of the most common malignant tumors. The aim of the present study was to identify key genes and pathways to improve the understanding of the mechanism of CRC. GSE87211, including 203 CRC samples and 160 control samples, was screened to identify differentially expressed genes (DEGs). In total, 853 DEGs were obtained, including 363 upregulated genes and 490 downregulated genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of DEGs were performed to obtain enrichment datasets. GO analysis showed that DEGs were significantly enriched in the extracellular region, cell-cell signaling, hormone activity, and cytokine activity. KEGG pathway analysis revealed that the DEGs were mainly enriched in the cytokine-cytokine receptor interaction, drug metabolism, androgen and estrogen metabolism, and neuroactive ligand-receptor interaction. The Protein-Protein Interaction (PPI) network of DEGs was constructed by using Search Tool for the Retrieval of Interacting Genes (STRING). The app MCODE plugged in Cytoscape was used to explore the key modules involved in disease development. 43 key genes involved in the top two modules were identified. Six hub genes (CXCL 2 , CXCL 3 , PTGDR2, GRP, CXCL 11 , and AGTR1) were statistically associated with patient overall survival or disease-free survival. The functions of six hub genes were mainly related to the hormone and chemokine activities. In conclusion, the present study may help understand the molecular mechanisms of CRC development." @default.
- W2987537683 created "2019-11-22" @default.
- W2987537683 creator A5014661038 @default.
- W2987537683 creator A5041249821 @default.
- W2987537683 date "2019-11-06" @default.
- W2987537683 modified "2023-10-18" @default.
- W2987537683 title "Hub Genes and Key Pathway Identification in Colorectal Cancer Based on Bioinformatic Analysis" @default.
- W2987537683 cites W1965531953 @default.
- W2987537683 cites W1986986419 @default.
- W2987537683 cites W2006683252 @default.
- W2987537683 cites W2028816293 @default.
- W2987537683 cites W2079936627 @default.
- W2987537683 cites W2104265287 @default.
- W2987537683 cites W2112887890 @default.
- W2987537683 cites W2140149776 @default.
- W2987537683 cites W2146233513 @default.
- W2987537683 cites W2272984102 @default.
- W2987537683 cites W2288326375 @default.
- W2987537683 cites W2290587140 @default.
- W2987537683 cites W2511283352 @default.
- W2987537683 cites W2606281208 @default.
- W2987537683 cites W2607129810 @default.
- W2987537683 cites W2613716330 @default.
- W2987537683 cites W2749717647 @default.
- W2987537683 cites W2758889181 @default.
- W2987537683 cites W2770893462 @default.
- W2987537683 cites W2793015008 @default.
- W2987537683 cites W2795229823 @default.
- W2987537683 cites W2904592547 @default.
- W2987537683 cites W2904973250 @default.
- W2987537683 cites W2907695702 @default.
- W2987537683 cites W2920863623 @default.
- W2987537683 cites W2947468316 @default.
- W2987537683 cites W2949821018 @default.
- W2987537683 cites W2950319780 @default.
- W2987537683 cites W2950408983 @default.
- W2987537683 cites W2950823359 @default.
- W2987537683 cites W2951206054 @default.
- W2987537683 doi "https://doi.org/10.1155/2019/1545680" @default.
- W2987537683 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6874977" @default.
- W2987537683 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31781593" @default.
- W2987537683 hasPublicationYear "2019" @default.
- W2987537683 type Work @default.
- W2987537683 sameAs 2987537683 @default.
- W2987537683 citedByCount "16" @default.
- W2987537683 countsByYear W29875376832021 @default.
- W2987537683 countsByYear W29875376832022 @default.
- W2987537683 countsByYear W29875376832023 @default.
- W2987537683 crossrefType "journal-article" @default.
- W2987537683 hasAuthorship W2987537683A5014661038 @default.
- W2987537683 hasAuthorship W2987537683A5041249821 @default.
- W2987537683 hasBestOaLocation W29875376831 @default.
- W2987537683 hasConcept C104317684 @default.
- W2987537683 hasConcept C150194340 @default.
- W2987537683 hasConcept C152724338 @default.
- W2987537683 hasConcept C162317418 @default.
- W2987537683 hasConcept C54355233 @default.
- W2987537683 hasConcept C60644358 @default.
- W2987537683 hasConcept C70721500 @default.
- W2987537683 hasConcept C86803240 @default.
- W2987537683 hasConceptScore W2987537683C104317684 @default.
- W2987537683 hasConceptScore W2987537683C150194340 @default.
- W2987537683 hasConceptScore W2987537683C152724338 @default.
- W2987537683 hasConceptScore W2987537683C162317418 @default.
- W2987537683 hasConceptScore W2987537683C54355233 @default.
- W2987537683 hasConceptScore W2987537683C60644358 @default.
- W2987537683 hasConceptScore W2987537683C70721500 @default.
- W2987537683 hasConceptScore W2987537683C86803240 @default.
- W2987537683 hasLocation W29875376831 @default.
- W2987537683 hasLocation W29875376832 @default.
- W2987537683 hasLocation W29875376833 @default.
- W2987537683 hasLocation W29875376834 @default.
- W2987537683 hasOpenAccess W2987537683 @default.
- W2987537683 hasPrimaryLocation W29875376831 @default.
- W2987537683 hasRelatedWork W1991523530 @default.
- W2987537683 hasRelatedWork W2002128513 @default.
- W2987537683 hasRelatedWork W2020824267 @default.
- W2987537683 hasRelatedWork W2171277769 @default.
- W2987537683 hasRelatedWork W2909382709 @default.
- W2987537683 hasRelatedWork W3200763748 @default.
- W2987537683 hasRelatedWork W3217162714 @default.
- W2987537683 hasRelatedWork W4281916997 @default.
- W2987537683 hasRelatedWork W4385334780 @default.
- W2987537683 hasRelatedWork W2092874662 @default.
- W2987537683 hasVolume "2019" @default.
- W2987537683 isParatext "false" @default.
- W2987537683 isRetracted "false" @default.
- W2987537683 magId "2987537683" @default.
- W2987537683 workType "article" @default.