FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2987638723> ?p ?o ?g. }

• W2987638723 endingPage "e0225390" @default.
• W2987638723 startingPage "e0225390" @default.
• W2987638723 abstract "Adherence to antihypertensive drugs in patients with diabetes is important. To support adherence, attention should be paid to the dynamic process of implementation, persistence and reinitiation of these drugs. We assessed non-adherence, non-persistence and reinitiation patterns for antihypertensive drugs in patients on oral diabetes drugs and identified pharmacy-based predictors of these processes.We conducted a cohort study in patients on oral diabetes drugs who initiated antihypertensive drugs between 1995-2015, as registered in the IADB.nl pharmacy database. Non-adherence was defined as a medication possession ratio < 80% and non-persistence as a gap > 180 days. We defined reinitiation as the dispensing of an antihypertensive drug within one year following discontinuation. We provide descriptive statistics for different time periods and applied logistic and Cox regressions to assess associations with sociodemographic and drug-related factors.Of 6,669 initiators, non-adherence rates in persistent patients decreased from 11.0% in the first year to 8.5% and 7.7% in the second and third years, respectively. Non-persistence rates decreased from 18.0% in the first year to 3.7% and 2.9% in the second and third years, respectively. Of the 1,201 patients who discontinued in the first year, 22.0% reinitiated treatment within one year. Non-adherence and non-persistence rates were lower in the more recent time period. Predictors of non-adherence were secondary prevention (OR: 1.45; 95% CI: 1.10-1.93) and diuretics as initial drug class (OR: 1.37; 95% CI: 1.08-1.74). Predictors of non-persistence were female gender (HR: 1.18; 95% CI: 1.05-1.32), older age (HR: 1.33; 95% CI: 1.08-1.63) and diuretics, beta-blocking agents or calcium channel blockers as initial drug class. Longer duration of persistence was a predictor of reinitiation.Adherence to antihypertensive drugs in patients on oral diabetes drugs has improved over time. The first year after initiation is the most crucial with regard to non-adherence and non-persistence, and the risk groups are different for both processes. Early non-persistence is a risk factor for not reinitiating treatment." @default.
• W2987638723 created "2019-11-22" @default.
• W2987638723 creator A5029966007 @default.
• W2987638723 creator A5033079155 @default.
• W2987638723 creator A5037086907 @default.
• W2987638723 creator A5064156089 @default.
• W2987638723 date "2019-11-15" @default.
• W2987638723 modified "2023-09-27" @default.
• W2987638723 title "Pharmacy-based predictors of non-adherence, non-persistence and reinitiation of antihypertensive drugs among patients on oral diabetes drugs in the Netherlands" @default.
• W2987638723 cites W106293662 @default.
• W2987638723 cites W1484612952 @default.
• W2987638723 cites W1741567663 @default.
• W2987638723 cites W1975658002 @default.
• W2987638723 cites W1979837385 @default.
• W2987638723 cites W1986541063 @default.
• W2987638723 cites W1992753345 @default.
• W2987638723 cites W2009153615 @default.
• W2987638723 cites W2016503459 @default.
• W2987638723 cites W2020636528 @default.
• W2987638723 cites W2028633414 @default.
• W2987638723 cites W2040445085 @default.
• W2987638723 cites W2041475300 @default.
• W2987638723 cites W2046755163 @default.
• W2987638723 cites W2060082266 @default.
• W2987638723 cites W2064279271 @default.
• W2987638723 cites W2067694868 @default.
• W2987638723 cites W2074540219 @default.
• W2987638723 cites W2080983906 @default.
• W2987638723 cites W2089064114 @default.
• W2987638723 cites W2094121837 @default.
• W2987638723 cites W2124129401 @default.
• W2987638723 cites W2139584372 @default.
• W2987638723 cites W2154579091 @default.
• W2987638723 cites W2155828626 @default.
• W2987638723 cites W2164733897 @default.
• W2987638723 cites W2223422507 @default.
• W2987638723 cites W2316962890 @default.
• W2987638723 cites W2342061947 @default.
• W2987638723 cites W2782004634 @default.
• W2987638723 cites W2811496043 @default.
• W2987638723 cites W2885920730 @default.
• W2987638723 cites W2905449663 @default.
• W2987638723 cites W4213222556 @default.
• W2987638723 doi "https://doi.org/10.1371/journal.pone.0225390" @default.
• W2987638723 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6857926" @default.
• W2987638723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31730627" @default.
• W2987638723 hasPublicationYear "2019" @default.
• W2987638723 type Work @default.
• W2987638723 sameAs 2987638723 @default.
• W2987638723 citedByCount "14" @default.
• W2987638723 countsByYear W29876387232020 @default.
• W2987638723 countsByYear W29876387232021 @default.
• W2987638723 countsByYear W29876387232022 @default.
• W2987638723 countsByYear W29876387232023 @default.
• W2987638723 crossrefType "journal-article" @default.
• W2987638723 hasAuthorship W2987638723A5029966007 @default.
• W2987638723 hasAuthorship W2987638723A5033079155 @default.
• W2987638723 hasAuthorship W2987638723A5037086907 @default.
• W2987638723 hasAuthorship W2987638723A5064156089 @default.
• W2987638723 hasBestOaLocation W29876387231 @default.
• W2987638723 hasConcept C104863432 @default.
• W2987638723 hasConcept C126322002 @default.
• W2987638723 hasConcept C127413603 @default.
• W2987638723 hasConcept C134018914 @default.
• W2987638723 hasConcept C151956035 @default.
• W2987638723 hasConcept C187320778 @default.
• W2987638723 hasConcept C2778176773 @default.
• W2987638723 hasConcept C2778715236 @default.
• W2987638723 hasConcept C2780035454 @default.
• W2987638723 hasConcept C2781009140 @default.
• W2987638723 hasConcept C512399662 @default.
• W2987638723 hasConcept C555293320 @default.
• W2987638723 hasConcept C71924100 @default.
• W2987638723 hasConcept C72563966 @default.
• W2987638723 hasConcept C98274493 @default.
• W2987638723 hasConceptScore W2987638723C104863432 @default.
• W2987638723 hasConceptScore W2987638723C126322002 @default.
• W2987638723 hasConceptScore W2987638723C127413603 @default.
• W2987638723 hasConceptScore W2987638723C134018914 @default.
• W2987638723 hasConceptScore W2987638723C151956035 @default.
• W2987638723 hasConceptScore W2987638723C187320778 @default.
• W2987638723 hasConceptScore W2987638723C2778176773 @default.
• W2987638723 hasConceptScore W2987638723C2778715236 @default.
• W2987638723 hasConceptScore W2987638723C2780035454 @default.
• W2987638723 hasConceptScore W2987638723C2781009140 @default.
• W2987638723 hasConceptScore W2987638723C512399662 @default.
• W2987638723 hasConceptScore W2987638723C555293320 @default.
• W2987638723 hasConceptScore W2987638723C71924100 @default.
• W2987638723 hasConceptScore W2987638723C72563966 @default.
• W2987638723 hasConceptScore W2987638723C98274493 @default.
• W2987638723 hasFunder F4320328515 @default.
• W2987638723 hasIssue "11" @default.
• W2987638723 hasLocation W29876387231 @default.
• W2987638723 hasLocation W29876387232 @default.
• W2987638723 hasLocation W29876387233 @default.
• W2987638723 hasLocation W29876387234 @default.
• W2987638723 hasLocation W29876387235 @default.
• W2987638723 hasLocation W29876387236 @default.

• next