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• W2987662007 abstract "Atherosclerosis is considered to be a chronic inflammatory disease of the artery wall. Complications of atherosclerosis, such as myocardial infarction (MI) or ischemic stroke, are the major causes of disability and death in the modern world. Atorvastatin is broadly used as statin therapy to lower the serum lipid level with better safety and tolerance and is a class of statin medication that used in Iraqi healthcare services. The aim of the present study is to explore the expression level of miRNA146a and OX-LDL as a potential diagnostic biomarker of atherosclerotic coronary artery disease which depends upon vessel affected and its associated with the lipid lowering medication (atorvastatin). Subjects and methods A total of 200 blood specimens were collected from adults with atherosclerosis comprise 100 patients subdivided to patients with 20 mg atorvastatin (n = 52) and patients with 40 mg atorvastatin (n = 48), and healthy control subjects which comprise 100. The age range between 30‐ and 60 years old. The disease activity of patients᾿ groups to determine by vessel disease affected. OxLDL determined by competitive ELISA, relative quantification (RQ) of miRNA146a expression, in whole blood was estimated using reverse transcriptase quantitative real time polymerase chain reaction. The statistical analysis showed significant statistical differences between patients and healthy controls in multiple studied parameters. Regarding lipid profile and oxLDL levels in patients taking 20 mg atorvastatin were significantly higher than controls (P < .05). A significant difference in total cholesterol (TC) and low density lipoprotein (LDL-C) between two classes of patients with double disease affected and a significant decrease in the rate of oxidizing LDL (oxLDL) in patients with 40 mg compared to 20 mg. Highly significant upregulated gene expression of miRNA-146a in patients with 20 mg versus 40 mg and the highest folds in a single vessel was observed. OxLDL and miRNA146a demonstrated better performance in atherosclerotic coronary artery disease (ACAD) diagnosis, showing sensitivity (95.3; 75%) (AUC: 0.81; 0.83 at cutoff value 57.94; 1.17) P 0.05. The level of miRNA-146a is positively correlated with oxLDL (p < .05). The applicability of miRNA146a and ox-LDL as potential diagnostic biomarkers of ACAD, by using different protocols. Its diagnostic performance was better than lipid variable and other traditional risk factor. Therefore, our data strongly suggest measuring both parameters for more specific prediction of ACAD." @default.
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• W2987662007 date "2020-03-01" @default.
• W2987662007 modified "2023-09-26" @default.
• W2987662007 title "Plasma oxidized low-density lipoprotein level and miRNA-146a gene expression, as a strong predictor for atherosclerotic coronary artery disease and its associated response to atorvastatin in a sample of the Iraqi population" @default.
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• W2987662007 doi "https://doi.org/10.1016/j.genrep.2019.100563" @default.
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