Matches in SemOpenAlex for { <https://semopenalex.org/work/W2987706306> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2987706306 endingPage "vi138" @default.
- W2987706306 startingPage "vi138" @default.
- W2987706306 abstract "Abstract BACKGROUND Venous thromboembolism (VTE) is a debilitating and life-threating condition that is common in patients with cancer, especially glioma. Antithrombotic prophylaxis is controversial in glioma patients because of possible intracerebral hemorrhage. Effective VTE prediction models exist for patients with other cancers, but not glioma. Our prior publications suggested a protective role of IDH1 mutations (IDHmut) against VTE, as well as a positive association between elevated circulating Tissue Factor (TF), a procoagulant secreted by cancers, and VTE in glioma patients. Others have recently found a correlation between podoplanin, a platelet activator, and tumor-associated VTE, but this has not been proven in gliomas. Our objective is to develop a multidimensional VTE prediction tool to improve glioma patient care, incorporating clinical, blood-based, histologic, and molecular markers. METHODS The Northwestern University Nervous System Tumor Bank provided preoperative arterial blood, tumor tissue, and clinical-pathologic data from 265 grade II-IV glioma patients over a 3-year interval. Molecular profiling was done by GlioSeq NGS. RESULTS Seventy-seven out of 265 grade II-IV glioma patients (29%) experienced VTE during their disease course. VTE was itself a negative prognostic marker for median overall survival (18 vs. 54 months, P< 0.001). Positive risk factors for VTE included advanced patient age, high body mass index, high tumor grade, prior history of VTE, coronary artery disease, hyperlipidemia, hypertension, and elevated circulating TF activity. While tumor expression of podoplanin positively correlated with VTE, circulating podoplanin did not. Among molecular markers, only IDHmut correlated with VTE risk, and it was associated with greatly reduced risk (OR=0.28; 95% CI=0.12–0.64, P=0.001). CONCLUSIONS This study identified multiple risk factors for glioma-associated VTE. Using these data, we are developing a multivariable prediction calculator that will improve patient care by identifying patients who would benefit most from prophylactic anticoagulation." @default.
- W2987706306 created "2019-11-22" @default.
- W2987706306 creator A5002164393 @default.
- W2987706306 creator A5009670051 @default.
- W2987706306 creator A5011353980 @default.
- W2987706306 creator A5023585542 @default.
- W2987706306 creator A5027351735 @default.
- W2987706306 creator A5039676534 @default.
- W2987706306 creator A5040033062 @default.
- W2987706306 creator A5051028110 @default.
- W2987706306 creator A5051556128 @default.
- W2987706306 creator A5072438602 @default.
- W2987706306 date "2019-11-01" @default.
- W2987706306 modified "2023-09-26" @default.
- W2987706306 title "INNV-42. VENOUS THROMBOEMBOLISM RISK ASSESSMENT IN PATIENTS WITH GLIOMA" @default.
- W2987706306 doi "https://doi.org/10.1093/neuonc/noz175.581" @default.
- W2987706306 hasPublicationYear "2019" @default.
- W2987706306 type Work @default.
- W2987706306 sameAs 2987706306 @default.
- W2987706306 citedByCount "0" @default.
- W2987706306 crossrefType "journal-article" @default.
- W2987706306 hasAuthorship W2987706306A5002164393 @default.
- W2987706306 hasAuthorship W2987706306A5009670051 @default.
- W2987706306 hasAuthorship W2987706306A5011353980 @default.
- W2987706306 hasAuthorship W2987706306A5023585542 @default.
- W2987706306 hasAuthorship W2987706306A5027351735 @default.
- W2987706306 hasAuthorship W2987706306A5039676534 @default.
- W2987706306 hasAuthorship W2987706306A5040033062 @default.
- W2987706306 hasAuthorship W2987706306A5051028110 @default.
- W2987706306 hasAuthorship W2987706306A5051556128 @default.
- W2987706306 hasAuthorship W2987706306A5072438602 @default.
- W2987706306 hasBestOaLocation W29877063061 @default.
- W2987706306 hasConcept C121608353 @default.
- W2987706306 hasConcept C126322002 @default.
- W2987706306 hasConcept C143998085 @default.
- W2987706306 hasConcept C2777015399 @default.
- W2987706306 hasConcept C2778227246 @default.
- W2987706306 hasConcept C502942594 @default.
- W2987706306 hasConcept C71924100 @default.
- W2987706306 hasConcept C90924648 @default.
- W2987706306 hasConceptScore W2987706306C121608353 @default.
- W2987706306 hasConceptScore W2987706306C126322002 @default.
- W2987706306 hasConceptScore W2987706306C143998085 @default.
- W2987706306 hasConceptScore W2987706306C2777015399 @default.
- W2987706306 hasConceptScore W2987706306C2778227246 @default.
- W2987706306 hasConceptScore W2987706306C502942594 @default.
- W2987706306 hasConceptScore W2987706306C71924100 @default.
- W2987706306 hasConceptScore W2987706306C90924648 @default.
- W2987706306 hasIssue "Supplement_6" @default.
- W2987706306 hasLocation W29877063061 @default.
- W2987706306 hasLocation W29877063062 @default.
- W2987706306 hasOpenAccess W2987706306 @default.
- W2987706306 hasPrimaryLocation W29877063061 @default.
- W2987706306 hasRelatedWork W2517015656 @default.
- W2987706306 hasRelatedWork W2517354513 @default.
- W2987706306 hasRelatedWork W2599306953 @default.
- W2987706306 hasRelatedWork W2766845515 @default.
- W2987706306 hasRelatedWork W2893427112 @default.
- W2987706306 hasRelatedWork W2906583422 @default.
- W2987706306 hasRelatedWork W3000724560 @default.
- W2987706306 hasRelatedWork W3028012141 @default.
- W2987706306 hasRelatedWork W3159138021 @default.
- W2987706306 hasRelatedWork W4206060802 @default.
- W2987706306 hasVolume "21" @default.
- W2987706306 isParatext "false" @default.
- W2987706306 isRetracted "false" @default.
- W2987706306 magId "2987706306" @default.
- W2987706306 workType "article" @default.