FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2987756070> ?p ?o ?g. }

• W2987756070 abstract "Abstract Dendritic spikes in thin dendritic branches (basal and oblique dendrites) of pyramidal neurons are traditionally inferred from spikelets measured in the cell body. Here, we used laser-spot voltage-sensitive dye imaging in cortical pyramidal neurons (rat brain slices) to investigate the voltage waveforms of dendritic potentials occurring in response to spatially-restricted glutamatergic inputs. Local dendritic potentials lasted 200–500 ms and propagated to the cell body where they caused sustained 10-20 mV depolarizations. Plateau potentials propagating from dendrite to soma, and action potentials propagating from soma to dendrite, created complex voltage waveforms in the middle of the thin basal dendrite, comprised of local sodium spikelets, local plateau potentials, and back-propagating action potentials, superimposed on each other. Our model replicated these experimental observations and made predictions, which were tested in experiments. Dendritic plateau potentials occurring in basal and oblique branches put pyramidal neurons into an activated neuronal state (“prepared state”), characterized by depolarized membrane potential and faster membrane responses. The prepared state provides a time window of 200-500 ms during which cortical neurons are particularly excitable and capable of following afferent inputs. At the network level, this predicts that sets of cells with simultaneous plateaus would provide cellular substrate for the formation of functional neuronal ensembles. New & Noteworthy In cortical pyramidal neurons, we recorded glutamate-mediated dendritic plateau potentials using voltage imaging, and created a computer model that recreated experimental measures from dendrite and cell body. Our model made new predictions, which were then tested in experiments. Plateau potentials profoundly change neuronal state -- a plateau potential triggered in one basal dendrite depolarizes the soma and shortens membrane time constant, making the cell more susceptible to firing triggered by other afferent inputs." @default.
• W2987756070 created "2019-11-22" @default.
• W2987756070 creator A5024837522 @default.
• W2987756070 creator A5027748067 @default.
• W2987756070 creator A5039229085 @default.
• W2987756070 creator A5044060170 @default.
• W2987756070 creator A5056426700 @default.
• W2987756070 creator A5065359796 @default.
• W2987756070 creator A5071370049 @default.
• W2987756070 creator A5082122443 @default.
• W2987756070 creator A5088113273 @default.
• W2987756070 date "2019-11-02" @default.
• W2987756070 modified "2023-10-18" @default.
• W2987756070 title "Local Glutamate-Mediated Dendritic Plateau Potentials Change the State of the Cortical Pyramidal Neuron" @default.
• W2987756070 cites W1520210681 @default.
• W2987756070 cites W1558113371 @default.
• W2987756070 cites W1587372183 @default.
• W2987756070 cites W1645542202 @default.
• W2987756070 cites W1897919376 @default.
• W2987756070 cites W1971944962 @default.
• W2987756070 cites W1972759447 @default.
• W2987756070 cites W1973137648 @default.
• W2987756070 cites W1974719053 @default.
• W2987756070 cites W1975776821 @default.
• W2987756070 cites W1979009696 @default.
• W2987756070 cites W1983101457 @default.
• W2987756070 cites W1987510656 @default.
• W2987756070 cites W1995297165 @default.
• W2987756070 cites W1999134832 @default.
• W2987756070 cites W1999838582 @default.
• W2987756070 cites W2002918474 @default.
• W2987756070 cites W2013479315 @default.
• W2987756070 cites W2014905699 @default.
• W2987756070 cites W2016379134 @default.
• W2987756070 cites W2022707775 @default.
• W2987756070 cites W2023680694 @default.
• W2987756070 cites W2024776216 @default.
• W2987756070 cites W2031534534 @default.
• W2987756070 cites W2036021747 @default.
• W2987756070 cites W2037038958 @default.
• W2987756070 cites W2039940203 @default.
• W2987756070 cites W2047405616 @default.
• W2987756070 cites W2047598284 @default.
• W2987756070 cites W2047878451 @default.
• W2987756070 cites W2054434960 @default.
• W2987756070 cites W2055067231 @default.
• W2987756070 cites W2058858982 @default.
• W2987756070 cites W2063738372 @default.
• W2987756070 cites W2065469428 @default.
• W2987756070 cites W2067327770 @default.
• W2987756070 cites W2067840211 @default.
• W2987756070 cites W2072230901 @default.
• W2987756070 cites W2078170624 @default.
• W2987756070 cites W2080185027 @default.
• W2987756070 cites W2081287258 @default.
• W2987756070 cites W2083896210 @default.
• W2987756070 cites W2088755150 @default.
• W2987756070 cites W2110323906 @default.
• W2987756070 cites W2116797486 @default.
• W2987756070 cites W2117120818 @default.
• W2987756070 cites W2121239869 @default.
• W2987756070 cites W2123350104 @default.
• W2987756070 cites W2139975927 @default.
• W2987756070 cites W2140885691 @default.
• W2987756070 cites W2144925492 @default.
• W2987756070 cites W2150753693 @default.
• W2987756070 cites W2152685321 @default.
• W2987756070 cites W2154323800 @default.
• W2987756070 cites W2156196802 @default.
• W2987756070 cites W2168943209 @default.
• W2987756070 cites W2171529265 @default.
• W2987756070 cites W2286046377 @default.
• W2987756070 cites W2411645165 @default.
• W2987756070 cites W2423540713 @default.
• W2987756070 cites W2533503574 @default.
• W2987756070 cites W2555072090 @default.
• W2987756070 cites W2562989337 @default.
• W2987756070 cites W2612427969 @default.
• W2987756070 cites W2619444695 @default.
• W2987756070 cites W2747517156 @default.
• W2987756070 cites W2753962205 @default.
• W2987756070 cites W2767528263 @default.
• W2987756070 cites W2798240694 @default.
• W2987756070 cites W2897717946 @default.
• W2987756070 cites W2981328134 @default.
• W2987756070 cites W2982442582 @default.
• W2987756070 doi "https://doi.org/10.1101/828582" @default.
• W2987756070 hasPublicationYear "2019" @default.
• W2987756070 type Work @default.
• W2987756070 sameAs 2987756070 @default.
• W2987756070 citedByCount "0" @default.
• W2987756070 crossrefType "posted-content" @default.
• W2987756070 hasAuthorship W2987756070A5024837522 @default.
• W2987756070 hasAuthorship W2987756070A5027748067 @default.
• W2987756070 hasAuthorship W2987756070A5039229085 @default.
• W2987756070 hasAuthorship W2987756070A5044060170 @default.
• W2987756070 hasAuthorship W2987756070A5056426700 @default.
• W2987756070 hasAuthorship W2987756070A5065359796 @default.
• W2987756070 hasAuthorship W2987756070A5071370049 @default.
• W2987756070 hasAuthorship W2987756070A5082122443 @default.

• next