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- W2987811700 abstract "Aspergillus fumigatus and Pseudomonas aeruginosa are the most prevalent fungal and bacterial pathogens associated with cystic-fibrosis-related infections, respectively. P. aeruginosa eventually predominates as the primary pathogen, though it is unknown why this is the case. Label-free quantitative proteomics was employed to investigate the cellular response of the alveolar epithelial cell line, A549, to coexposure of A. fumigatus and P. aeruginosa. These studies revealed a significant increase in the rate of P. aeruginosa proliferation where A. fumigatus was present. Shotgun proteomics performed on A549 cells exposed to either A. fumigatus or P. aeruginosa or to A. fumigatus and P. aeruginosa sequentially revealed distinct changes to the host cell proteome in response to either or both pathogens. While key signatures of infection were retained among all pathogen-exposed groups, including changes in mitochondrial activity and energy output, the relative abundance of proteins associated with endocytosis, phagosomes, and lysosomes was decreased in sequentially exposed cells compared to cells exposed to either pathogen. Our findings indicate that A. fumigatus renders A549 cells unable to internalize bacteria, thus providing an environment in which P. aeruginosa can proliferate. This research provides novel insights into the whole-cell proteomic response of A549 cells to A. fumigatus and P. aeruginosa and highlights distinct differences in the proteome following sequential exposure to both pathogens, which may explain why P. aeruginosa can predominate." @default.
- W2987811700 created "2019-11-22" @default.
- W2987811700 creator A5043776406 @default.
- W2987811700 creator A5068212578 @default.
- W2987811700 creator A5082507527 @default.
- W2987811700 date "2019-11-06" @default.
- W2987811700 modified "2023-10-06" @default.
- W2987811700 title "Characterization of the Proteomic Response of A549 Cells Following Sequential Exposure to <i>Aspergillus fumigatus</i> and <i>Pseudomonas aeruginosa</i>" @default.
- W2987811700 cites W1505086866 @default.
- W2987811700 cites W1586362463 @default.
- W2987811700 cites W1911723645 @default.
- W2987811700 cites W1927734345 @default.
- W2987811700 cites W1967104197 @default.
- W2987811700 cites W1970953122 @default.
- W2987811700 cites W1971383754 @default.
- W2987811700 cites W1971664002 @default.
- W2987811700 cites W1972897007 @default.
- W2987811700 cites W1973988376 @default.
- W2987811700 cites W1981764881 @default.
- W2987811700 cites W1984693521 @default.
- W2987811700 cites W1985035909 @default.
- W2987811700 cites W1990232129 @default.
- W2987811700 cites W1991185106 @default.
- W2987811700 cites W1991774743 @default.
- W2987811700 cites W1996762614 @default.
- W2987811700 cites W1999278724 @default.
- W2987811700 cites W2000444249 @default.
- W2987811700 cites W2007921798 @default.
- W2987811700 cites W2014413639 @default.
- W2987811700 cites W2026092723 @default.
- W2987811700 cites W2028980647 @default.
- W2987811700 cites W2029038776 @default.
- W2987811700 cites W2031516834 @default.
- W2987811700 cites W2045640310 @default.
- W2987811700 cites W2055167909 @default.
- W2987811700 cites W2056807570 @default.
- W2987811700 cites W2057144329 @default.
- W2987811700 cites W2058934051 @default.
- W2987811700 cites W2059041864 @default.
- W2987811700 cites W2076716995 @default.
- W2987811700 cites W2079959569 @default.
- W2987811700 cites W2087790613 @default.
- W2987811700 cites W2089726284 @default.
- W2987811700 cites W2092383206 @default.
- W2987811700 cites W2097298997 @default.
- W2987811700 cites W2099093477 @default.
- W2987811700 cites W2104276267 @default.
- W2987811700 cites W2111414094 @default.
- W2987811700 cites W2112369943 @default.
- W2987811700 cites W2113613985 @default.
- W2987811700 cites W2114640540 @default.
- W2987811700 cites W2114770722 @default.
- W2987811700 cites W2115511578 @default.
- W2987811700 cites W2119409346 @default.
- W2987811700 cites W2124528309 @default.
- W2987811700 cites W2125283826 @default.
- W2987811700 cites W2125870848 @default.
- W2987811700 cites W2126745460 @default.
- W2987811700 cites W2132040510 @default.
- W2987811700 cites W2135818730 @default.
- W2987811700 cites W2137127369 @default.
- W2987811700 cites W2141197648 @default.
- W2987811700 cites W2144728717 @default.
- W2987811700 cites W2148054572 @default.
- W2987811700 cites W2151240150 @default.
- W2987811700 cites W2153911335 @default.
- W2987811700 cites W2153931434 @default.
- W2987811700 cites W2154063145 @default.
- W2987811700 cites W2163665700 @default.
- W2987811700 cites W2163754153 @default.
- W2987811700 cites W2166343786 @default.
- W2987811700 cites W2167049000 @default.
- W2987811700 cites W2169545551 @default.
- W2987811700 cites W2170861437 @default.
- W2987811700 cites W2171814265 @default.
- W2987811700 cites W2201817029 @default.
- W2987811700 cites W2209714275 @default.
- W2987811700 cites W2225487457 @default.
- W2987811700 cites W2236839872 @default.
- W2987811700 cites W2256617341 @default.
- W2987811700 cites W2290216457 @default.
- W2987811700 cites W2295902659 @default.
- W2987811700 cites W2316803818 @default.
- W2987811700 cites W2495893271 @default.
- W2987811700 cites W2508566482 @default.
- W2987811700 cites W2583179451 @default.
- W2987811700 cites W2606696784 @default.
- W2987811700 cites W2734422910 @default.
- W2987811700 cites W2765537442 @default.
- W2987811700 cites W2774061217 @default.
- W2987811700 cites W2799405617 @default.
- W2987811700 cites W2809218045 @default.
- W2987811700 cites W2888944359 @default.
- W2987811700 cites W2905949314 @default.
- W2987811700 cites W2921299578 @default.
- W2987811700 cites W311013591 @default.
- W2987811700 cites W4211151481 @default.
- W2987811700 cites W567038336 @default.