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- W2987848922 abstract "Abstract The synaptonemal complex is a multiprotein complex, which mediates the synapsis and recombination between homologous chromosomes during meiosis. The complex is comprised of two lateral elements and a central element connected by perpendicular transverse filaments (TFs). A 3D model based on actual morphological data of the SC is missing. Here, we applied electron tomography (ET) and manual feature extraction to generate a quantitative 3D model of the murine SC. We quantified the length (90 nm) and width (2 nm) of the TFs. Interestingly, the 80 TFs/µm are distributed asymmetrically in the central region of the SC challenging available models of SC organization. Furthermore, our detailed 3D topological analysis does not support a bilayered organization of the central region as proposed earlier. Overall, our quantitative analysis is relevant to understand the functions and dynamics of the SC and provides the basis for analyzing multiprotein complexes in their morphological context using ET." @default.
- W2987848922 created "2019-11-22" @default.
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- W2987848922 date "2019-11-06" @default.
- W2987848922 modified "2023-10-16" @default.
- W2987848922 title "Quantitative basis of meiotic chromosome synapsis analyzed by electron tomography" @default.
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- W2987848922 doi "https://doi.org/10.1038/s41598-019-52455-4" @default.
- W2987848922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6834585" @default.
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