FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2988019145> ?p ?o ?g. }

• W2988019145 endingPage "11" @default.
• W2988019145 startingPage "1" @default.
• W2988019145 abstract "The administration of glucocorticoids (GCs) for the treatment of traumatic brain injury (TBI) is controversial. Both protective and deleterious effects of GCs on the brain have been reported in previous studies, while the mechanisms are unclear. Most experimental studies have reported glucocorticoid receptor (GR)-mediated deleterious effects after TBI. Sufficient mineralocorticoid receptor (MR) activation was reported to be indispensable for normal function and survival of hippocampal neurons, but changes in MR expression and activation and the roles of MRs in the survival of neurons after TBI remain unclear. We hypothesized that inadequate MR expression and activation caused by TBI aggravates posttraumatic hippocampal apoptosis but that restoration by restoring MRs promotes the survival of neurons. Using a rat controlled cortical impact model, we examined plasma corticosterone, MR expression and activation, neuronal apoptosis in the hippocampus, and spatial memory on day 3 after injury with and without fludrocortisone (1 mg/kg) treatment. Plasma corticosterone levels were significantly reduced after TBI. In addition, both MR expression and activation were inhibited. Fludrocortisone treatment significantly increased both the expression and activation of MRs, reduced the number of apoptotic neurons and cell loss in the ipsilateral hippocampus, and subsequently improved spatial memory. Its protective effects were counteracted by the MR antagonist spironolactone. The results suggest that adequate expression and activation of MRs is crucial for the survival of neurons after TBI and that fludrocortisone protects hippocampal neurons via promoting MR expression and activation." @default.
• W2988019145 created "2019-11-22" @default.
• W2988019145 creator A5001021969 @default.
• W2988019145 creator A5012061252 @default.
• W2988019145 creator A5046881277 @default.
• W2988019145 creator A5066460853 @default.
• W2988019145 creator A5075733288 @default.
• W2988019145 creator A5079301669 @default.
• W2988019145 creator A5086269424 @default.
• W2988019145 creator A5086301136 @default.
• W2988019145 date "2020-01-01" @default.
• W2988019145 modified "2023-09-26" @default.
• W2988019145 title "Inadequate Expression and Activation of Mineralocorticoid Receptor Aggravates Spatial Memory Impairment after Traumatic Brain Injury" @default.
• W2988019145 cites W1736650634 @default.
• W2988019145 cites W184300591 @default.
• W2988019145 cites W1904677686 @default.
• W2988019145 cites W1951485924 @default.
• W2988019145 cites W1969068738 @default.
• W2988019145 cites W1975252975 @default.
• W2988019145 cites W1984943674 @default.
• W2988019145 cites W1985442160 @default.
• W2988019145 cites W1991207646 @default.
• W2988019145 cites W1994580609 @default.
• W2988019145 cites W1995684466 @default.
• W2988019145 cites W1995921594 @default.
• W2988019145 cites W1996449070 @default.
• W2988019145 cites W2003348781 @default.
• W2988019145 cites W2004872316 @default.
• W2988019145 cites W2022647670 @default.
• W2988019145 cites W2022838353 @default.
• W2988019145 cites W2025743225 @default.
• W2988019145 cites W2029004410 @default.
• W2988019145 cites W2030135572 @default.
• W2988019145 cites W2037004891 @default.
• W2988019145 cites W2040465695 @default.
• W2988019145 cites W2055723753 @default.
• W2988019145 cites W2062104532 @default.
• W2988019145 cites W2062714102 @default.
• W2988019145 cites W2067629356 @default.
• W2988019145 cites W2074802748 @default.
• W2988019145 cites W2074810352 @default.
• W2988019145 cites W2079358325 @default.
• W2988019145 cites W2084608025 @default.
• W2988019145 cites W2086070682 @default.
• W2988019145 cites W2092327987 @default.
• W2988019145 cites W2093400617 @default.
• W2988019145 cites W2104706940 @default.
• W2988019145 cites W2117527060 @default.
• W2988019145 cites W2120737609 @default.
• W2988019145 cites W2125967646 @default.
• W2988019145 cites W2129985526 @default.
• W2988019145 cites W2135160692 @default.
• W2988019145 cites W2151224994 @default.
• W2988019145 cites W2178224036 @default.
• W2988019145 cites W2414594846 @default.
• W2988019145 cites W2424182382 @default.
• W2988019145 cites W2464966002 @default.
• W2988019145 cites W2614346335 @default.
• W2988019145 cites W2619896461 @default.
• W2988019145 cites W2751708584 @default.
• W2988019145 cites W2754861217 @default.
• W2988019145 cites W2767813783 @default.
• W2988019145 cites W2792973160 @default.
• W2988019145 cites W2913447439 @default.
• W2988019145 cites W4294443837 @default.
• W2988019145 doi "https://doi.org/10.1016/j.neuroscience.2019.10.026" @default.
• W2988019145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31734415" @default.
• W2988019145 hasPublicationYear "2020" @default.
• W2988019145 type Work @default.
• W2988019145 sameAs 2988019145 @default.
• W2988019145 citedByCount "9" @default.
• W2988019145 countsByYear W29880191452020 @default.
• W2988019145 countsByYear W29880191452021 @default.
• W2988019145 countsByYear W29880191452022 @default.
• W2988019145 crossrefType "journal-article" @default.
• W2988019145 hasAuthorship W2988019145A5001021969 @default.
• W2988019145 hasAuthorship W2988019145A5012061252 @default.
• W2988019145 hasAuthorship W2988019145A5046881277 @default.
• W2988019145 hasAuthorship W2988019145A5066460853 @default.
• W2988019145 hasAuthorship W2988019145A5075733288 @default.
• W2988019145 hasAuthorship W2988019145A5079301669 @default.
• W2988019145 hasAuthorship W2988019145A5086269424 @default.
• W2988019145 hasAuthorship W2988019145A5086301136 @default.
• W2988019145 hasConcept C118552586 @default.
• W2988019145 hasConcept C126322002 @default.
• W2988019145 hasConcept C134018914 @default.
• W2988019145 hasConcept C148762608 @default.
• W2988019145 hasConcept C15744967 @default.
• W2988019145 hasConcept C169760540 @default.
• W2988019145 hasConcept C170493617 @default.
• W2988019145 hasConcept C189135053 @default.
• W2988019145 hasConcept C25498285 @default.
• W2988019145 hasConcept C2776069600 @default.
• W2988019145 hasConcept C2776899810 @default.
• W2988019145 hasConcept C2778709874 @default.
• W2988019145 hasConcept C2780352252 @default.
• W2988019145 hasConcept C2780841215 @default.
• W2988019145 hasConcept C2781017439 @default.

• next