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- W2988049610 abstract "Abstract Interleukin-6 (IL-6) induced glycolysis and therapeutic resistance is reported in some cell systems; however the mechanism of IL-6 induced glycolysis in radio-resistance is un-explored. Therefore to investigate, we treated Raw264.7 cells with IL-6 (1hr prior to irradiation) and examined the glycolytic flux. Increased expression of mRNA and protein levels of key glycolytic enzymes was observed after IL-6 treatment, which conferred glycolysis dependent resistance from radiation induced cell death. We further established that IL-6 induced glycolysis is activated by Akt signaling and knocking down Akt or inhibition of pan Akt phosphorylation significantly abrogated the IL-6 induced radio-resistance. Moreover, reduction of IL-6 induced pAkt level suppressed the expression of Hexokinase-2 and its translocation to the mitochondria, thereby inhibiting the glycolysis induced resistance to radiation. IL-6 induced glycolysis also minimized the radiation induced mitochondrial damage. These results suggest that IL-6 induced glycolysis observed in cells may be responsible for IL-6 mediated therapeutic radio-resistance in cancer cells, partly by activation of Akt signaling." @default.
- W2988049610 created "2019-11-22" @default.
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- W2988049610 date "2019-10-31" @default.
- W2988049610 modified "2023-10-18" @default.
- W2988049610 title "Interleukin-6 confers radio-resistance by inducing Akt mediated glycolysis and reducing mitochondrial damage in cells" @default.
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- W2988049610 doi "https://doi.org/10.1093/jb/mvz091" @default.
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