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• W2988087299 abstract "Magnetoresistive (MR) sensors coupled to a portable platform were used to detect carcinoembryonic antigen (CEA), a commonly used blood biomarker for colorectal cancer detection and stage monitoring in the clinical setting. Current methodologies for CEA detection, such as enzyme-linked immunosorbent assay, have certain disadvantages, in particular, low signal sensitivity and high background noise. These disadvantages can be overcome with MR sensors. The MR platform used in this work consisted of spin valve sensors, read-out electronic setup, magnetic nanoparticles, and an integrated microfluidics system. For the detection of CEA, antibodies were immobilized on the sensor's surface in a sandwich structure. MR detection of CEA was achieved with a sensitivity level of nanograms per milliliter, resulting in a calibration curve between 5 ng/ml and 10 μg/ml. This letter serves as proof-of-concept for protein detection using a portable lab-on-a-chip device." @default.
• W2988087299 created "2019-11-22" @default.
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• W2988087299 date "2019-01-01" @default.
• W2988087299 modified "2023-10-16" @default.
• W2988087299 title "Magnetoresistive Detection of Clinical Biomarker for Monitoring of Colorectal Cancer" @default.
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• W2988087299 doi "https://doi.org/10.1109/lmag.2019.2951339" @default.
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