FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2988199416> ?p ?o ?g. }

• W2988199416 endingPage "104673" @default.
• W2988199416 startingPage "104673" @default.
• W2988199416 abstract "Abstract The recently developed DJ-1 knockout (KO) rat models the DJ-1 (or PARK7) loss-of-function mutation responsible for one form of early-onset familial Parkinson's disease (PD). Prior studies demonstrate that DJ-1 KO rats present progressive dopamine (DA) cell body degeneration in the substantia nigra pars compacta between 4 and 8 months of age. Furthermore, as some motor deficits emerge before the significant loss of DA cells, this mutation may yield a period of DA neuron dysfunction preceding cell death that may also contribute to cognitive impairments in early PD. However, cognitive functions subserved by corticostriatal circuitry, as well as additional alterations to the neurochemistry of monoamine systems, are largely uncharacterized in the DJ-1 KO rat. We therefore assessed a variety of striatally-mediated behavioral tasks, as well as the integrity of dopamine and serotonin systems, in male DJ-1 KO rats and wild-type (WT) controls at 4, 6, and 8 months of age. We demonstrate that DJ-1 KO rats exhibited motor impairments, but have intact goal-directed control over behavior in an appetitive instrumental learning task. Further, preprotachykinin mRNA expression, a post-synaptic indicator of DA signaling, was significantly decreased in 4-month DJ-1 KO rats, while DA transporter binding in the dorsal striatum did not differ between genotypes at any of the ages examined. Striatal tyrosine hydroxylase levels were significantly increased in 8-month DJ-1 KO rats and tended to be higher than WT at 4 and 6 months. Lastly, serotonin transporter binding was increased in the medial and orbitofrontal cortices of 4-month old DJ-1 KO rats. These results suggest that the nigrostriatal dopaminergic and prefrontal serotoninergic systems are altered early in the progression of DJ-1 KO pathology, despite no overt loss of the DA innervation of the striatum, and thus may be associated with early alterations in the functions of corticostriatal systems." @default.
• W2988199416 created "2019-11-22" @default.
• W2988199416 creator A5012957895 @default.
• W2988199416 creator A5028552226 @default.
• W2988199416 creator A5079980459 @default.
• W2988199416 date "2020-02-01" @default.
• W2988199416 modified "2023-09-26" @default.
• W2988199416 title "Characterization of striatum-mediated behavior and neurochemistry in the DJ-1 knock-out rat model of Parkinson's disease" @default.
• W2988199416 cites W1512232574 @default.
• W2988199416 cites W1545592082 @default.
• W2988199416 cites W1593383161 @default.
• W2988199416 cites W1761627028 @default.
• W2988199416 cites W1922869549 @default.
• W2988199416 cites W1951544238 @default.
• W2988199416 cites W1965970654 @default.
• W2988199416 cites W1966556489 @default.
• W2988199416 cites W1971682638 @default.
• W2988199416 cites W1973300926 @default.
• W2988199416 cites W1974927898 @default.
• W2988199416 cites W1977166619 @default.
• W2988199416 cites W1977947329 @default.
• W2988199416 cites W1984941820 @default.
• W2988199416 cites W1986115821 @default.
• W2988199416 cites W1986550480 @default.
• W2988199416 cites W1997081993 @default.
• W2988199416 cites W1997296067 @default.
• W2988199416 cites W2003943670 @default.
• W2988199416 cites W2004025333 @default.
• W2988199416 cites W2009552365 @default.
• W2988199416 cites W2011248498 @default.
• W2988199416 cites W2012392954 @default.
• W2988199416 cites W2013699695 @default.
• W2988199416 cites W2019842877 @default.
• W2988199416 cites W2019922908 @default.
• W2988199416 cites W2023302444 @default.
• W2988199416 cites W2023430816 @default.
• W2988199416 cites W2028911868 @default.
• W2988199416 cites W2030554335 @default.
• W2988199416 cites W2034845121 @default.
• W2988199416 cites W2049625610 @default.
• W2988199416 cites W2050865611 @default.
• W2988199416 cites W2053170041 @default.
• W2988199416 cites W2057001461 @default.
• W2988199416 cites W2057364502 @default.
• W2988199416 cites W2058423830 @default.
• W2988199416 cites W2067590452 @default.
• W2988199416 cites W2067704171 @default.
• W2988199416 cites W2072812277 @default.
• W2988199416 cites W2074397899 @default.
• W2988199416 cites W2074531848 @default.
• W2988199416 cites W2085518947 @default.
• W2988199416 cites W2085553767 @default.
• W2988199416 cites W2086135180 @default.
• W2988199416 cites W2086241581 @default.
• W2988199416 cites W2090227765 @default.
• W2988199416 cites W2092933199 @default.
• W2988199416 cites W2093192797 @default.
• W2988199416 cites W2094623291 @default.
• W2988199416 cites W2096193724 @default.
• W2988199416 cites W2103768739 @default.
• W2988199416 cites W2104382960 @default.
• W2988199416 cites W2107254875 @default.
• W2988199416 cites W2107977469 @default.
• W2988199416 cites W2112337921 @default.
• W2988199416 cites W2112917428 @default.
• W2988199416 cites W2123986548 @default.
• W2988199416 cites W2125477506 @default.
• W2988199416 cites W2133191097 @default.
• W2988199416 cites W2135795032 @default.
• W2988199416 cites W2136439930 @default.
• W2988199416 cites W2140549509 @default.
• W2988199416 cites W2141277688 @default.
• W2988199416 cites W2146545384 @default.
• W2988199416 cites W2152223184 @default.
• W2988199416 cites W2153592313 @default.
• W2988199416 cites W2157416823 @default.
• W2988199416 cites W2160874664 @default.
• W2988199416 cites W2173749165 @default.
• W2988199416 cites W2754689594 @default.
• W2988199416 cites W2766142914 @default.
• W2988199416 cites W2793877036 @default.
• W2988199416 cites W2941656681 @default.
• W2988199416 cites W2953754509 @default.
• W2988199416 cites W4210952882 @default.
• W2988199416 cites W4211004647 @default.
• W2988199416 cites W4296930953 @default.
• W2988199416 cites W4313371819 @default.
• W2988199416 doi "https://doi.org/10.1016/j.nbd.2019.104673" @default.
• W2988199416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31734455" @default.
• W2988199416 hasPublicationYear "2020" @default.
• W2988199416 type Work @default.
• W2988199416 sameAs 2988199416 @default.
• W2988199416 citedByCount "14" @default.
• W2988199416 countsByYear W29881994162020 @default.
• W2988199416 countsByYear W29881994162021 @default.
• W2988199416 countsByYear W29881994162022 @default.
• W2988199416 countsByYear W29881994162023 @default.
• W2988199416 crossrefType "journal-article" @default.

• next