FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2988267949> ?p ?o ?g. }

• W2988267949 abstract "17(R),18(S)-Epoxyeicosatetraenoic acid (EEQ) is a cytochrome P450 metabolite of eicosapentaenoic acid (EPA) and a powerful negative chronotrope with low nanomolar activity in a neonatal rat cardiomyocyte (NRCM) arrhythmia model. Prior studies identified oxamide 2b as a soluble epoxide hydrolase (sEH) stable replacement but unsuitable for in vivo applications due to limited oral bioavailability and metabolic stability. These ADME limitations have been addressed in an improved generation of negative chronotropes, e.g., 4 and 16, which were evaluated as potential clinical candidates." @default.
• W2988267949 created "2019-11-22" @default.
• W2988267949 creator A5003909286 @default.
• W2988267949 creator A5006087353 @default.
• W2988267949 creator A5019067361 @default.
• W2988267949 creator A5020555164 @default.
• W2988267949 creator A5022933852 @default.
• W2988267949 creator A5023470534 @default.
• W2988267949 creator A5023781997 @default.
• W2988267949 creator A5033545581 @default.
• W2988267949 creator A5035592501 @default.
• W2988267949 creator A5049601795 @default.
• W2988267949 creator A5077198825 @default.
• W2988267949 creator A5085965111 @default.
• W2988267949 date "2019-11-06" @default.
• W2988267949 modified "2023-10-16" @default.
• W2988267949 title "Development of Robust 17(R),18(S)-Epoxyeicosatetraenoic Acid (17,18-EEQ) Analogs as Potential Clinical Antiarrhythmic Agents" @default.
• W2988267949 cites W105391546 @default.
• W2988267949 cites W1939670273 @default.
• W2988267949 cites W1967323363 @default.
• W2988267949 cites W1972237531 @default.
• W2988267949 cites W1975116761 @default.
• W2988267949 cites W1975795641 @default.
• W2988267949 cites W1975947882 @default.
• W2988267949 cites W1979566472 @default.
• W2988267949 cites W1988830375 @default.
• W2988267949 cites W1995858991 @default.
• W2988267949 cites W1996615849 @default.
• W2988267949 cites W1997478226 @default.
• W2988267949 cites W2001075246 @default.
• W2988267949 cites W2035309737 @default.
• W2988267949 cites W2039171739 @default.
• W2988267949 cites W2040837322 @default.
• W2988267949 cites W2046397438 @default.
• W2988267949 cites W2058617365 @default.
• W2988267949 cites W2061869396 @default.
• W2988267949 cites W2067044904 @default.
• W2988267949 cites W2074998701 @default.
• W2988267949 cites W2081628220 @default.
• W2988267949 cites W2095070004 @default.
• W2988267949 cites W2102022125 @default.
• W2988267949 cites W2135498589 @default.
• W2988267949 cites W2137297265 @default.
• W2988267949 cites W2139086060 @default.
• W2988267949 cites W2150541210 @default.
• W2988267949 cites W2151324766 @default.
• W2988267949 cites W2163021618 @default.
• W2988267949 cites W2167890506 @default.
• W2988267949 cites W2294668782 @default.
• W2988267949 cites W2403381988 @default.
• W2988267949 cites W2464452988 @default.
• W2988267949 cites W2768051700 @default.
• W2988267949 cites W2793861760 @default.
• W2988267949 cites W2899557002 @default.
• W2988267949 cites W2953232704 @default.
• W2988267949 doi "https://doi.org/10.1021/acs.jmedchem.9b00952" @default.
• W2988267949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31693857" @default.
• W2988267949 hasPublicationYear "2019" @default.
• W2988267949 type Work @default.
• W2988267949 sameAs 2988267949 @default.
• W2988267949 citedByCount "7" @default.
• W2988267949 countsByYear W29882679492020 @default.
• W2988267949 countsByYear W29882679492021 @default.
• W2988267949 countsByYear W29882679492022 @default.
• W2988267949 crossrefType "journal-article" @default.
• W2988267949 hasAuthorship W2988267949A5003909286 @default.
• W2988267949 hasAuthorship W2988267949A5006087353 @default.
• W2988267949 hasAuthorship W2988267949A5019067361 @default.
• W2988267949 hasAuthorship W2988267949A5020555164 @default.
• W2988267949 hasAuthorship W2988267949A5022933852 @default.
• W2988267949 hasAuthorship W2988267949A5023470534 @default.
• W2988267949 hasAuthorship W2988267949A5023781997 @default.
• W2988267949 hasAuthorship W2988267949A5033545581 @default.
• W2988267949 hasAuthorship W2988267949A5035592501 @default.
• W2988267949 hasAuthorship W2988267949A5049601795 @default.
• W2988267949 hasAuthorship W2988267949A5077198825 @default.
• W2988267949 hasAuthorship W2988267949A5085965111 @default.
• W2988267949 hasConcept C150903083 @default.
• W2988267949 hasConcept C181199279 @default.
• W2988267949 hasConcept C181389837 @default.
• W2988267949 hasConcept C185592680 @default.
• W2988267949 hasConcept C18605011 @default.
• W2988267949 hasConcept C202751555 @default.
• W2988267949 hasConcept C207001950 @default.
• W2988267949 hasConcept C2777477808 @default.
• W2988267949 hasConcept C55493867 @default.
• W2988267949 hasConcept C69366308 @default.
• W2988267949 hasConcept C71924100 @default.
• W2988267949 hasConcept C86803240 @default.
• W2988267949 hasConcept C98274493 @default.
• W2988267949 hasConceptScore W2988267949C150903083 @default.
• W2988267949 hasConceptScore W2988267949C181199279 @default.
• W2988267949 hasConceptScore W2988267949C181389837 @default.
• W2988267949 hasConceptScore W2988267949C185592680 @default.
• W2988267949 hasConceptScore W2988267949C18605011 @default.
• W2988267949 hasConceptScore W2988267949C202751555 @default.
• W2988267949 hasConceptScore W2988267949C207001950 @default.
• W2988267949 hasConceptScore W2988267949C2777477808 @default.
• W2988267949 hasConceptScore W2988267949C55493867 @default.
• W2988267949 hasConceptScore W2988267949C69366308 @default.

• next