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- W2988284154 abstract "The findings from clinical trials on the association between blood pressure lowering treatment and the prevention of dementia have been inconsistent. Hence, recent efforts have focused on defining the relationship between antihypertensive drug classes and incident dementia. These studies have tried to understand the pleiotropic effects of drugs on the brain through systematic reviews and meta-analyses. 1 Levi Marpillat N Macquin-Mavier I Tropeano AI Bachoud-Levi AC Maison P Antihypertensive classes, cognitive decline and incidence of dementia: a network meta-analysis. J Hypertens. 2013; 31: 1073-1082 Crossref PubMed Scopus (181) Google Scholar , 2 Peters R Booth A Peters J A systematic review of calcium channel blocker use and cognitive decline/dementia in the elderly. J Hypertens. 2014; 32 (discussion 1957–58.): 1945-1957 Crossref PubMed Scopus (40) Google Scholar , 3 Tully PJ Hanon O Cosh S Tzourio C Diuretic antihypertensive drugs and incident dementia risk: a systematic review, meta-analysis and meta-regression of prospective studies. J Hypertens. 2016; 34: 1027-1035 Crossref PubMed Scopus (48) Google Scholar , 4 Gelber RP Ross GW Petrovitch H Masaki KH Launer LJ White LR Antihypertensive medication use and risk of cognitive impairment: the Honolulu-Asia Aging Study. Neurology. 2013; 81: 888-895 Crossref PubMed Scopus (75) Google Scholar However, such analyses of aggregate data have limited potential to account for variation in methods and populations, and to adjust for confounders. Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studiesOver a long period of observation, no evidence was found that a specific AHM drug class was more effective than others in lowering risk of dementia. Among people with hypertensive levels of blood pressure, use of any AHM with efficacy to lower blood pressure might reduce the risk for dementia. These findings suggest future clinical guidelines for hypertension management should also consider the beneficial effect of AHM on the risk for dementia. Full-Text PDF" @default.
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- W2988284154 date "2020-01-01" @default.
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- W2988284154 title "Advancing dementia prevention through effective blood pressure control" @default.
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- W2988284154 doi "https://doi.org/10.1016/s1474-4422(19)30407-7" @default.
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