FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2988292303> ?p ?o ?g. }

• W2988292303 endingPage "110067" @default.
• W2988292303 startingPage "110067" @default.
• W2988292303 abstract "Therapeutic cancer vaccines often do not substantially reduce tumour burden, despite stimulating anti-tumour cytotoxic T lymphocytes (CTLs). Recent experiments have shown that the majority of vaccine-elicited CTLs may be of low-avidity. Moreover, low-avidity CTLs, which are abundant, do not kill cancer cells and potentially inhibit the ability of high-avidity T cells to kill cancer cells. By modelling CTL selection using a system of ordinary differential equations, we show that the efficacy of the peptide vaccine may be improved by controlling its delivery and dosage to preferentially elicit high-avidity CTLs. Our simulations predict that weekly, reduced doses of a vaccine may result in a greater than 90% reduction in cancer concentration. By contrast, a standard vaccine protocol such as a high-dose injection given every 2 weeks induces only a 65% reduction. Our model demonstrates a proof-of-concept approach to targeting immune responses for CTL selection, thereby offering a technique to potentially improve existing therapies." @default.
• W2988292303 created "2019-11-22" @default.
• W2988292303 creator A5035781067 @default.
• W2988292303 creator A5041098720 @default.
• W2988292303 creator A5084570861 @default.
• W2988292303 date "2020-02-01" @default.
• W2988292303 modified "2023-10-17" @default.
• W2988292303 title "Optimisation of anti-cancer peptide vaccines to preferentially elicit high-avidity T cells" @default.
• W2988292303 cites W1482928030 @default.
• W2988292303 cites W1501233675 @default.
• W2988292303 cites W1507800008 @default.
• W2988292303 cites W1509269909 @default.
• W2988292303 cites W1603918837 @default.
• W2988292303 cites W1794076386 @default.
• W2988292303 cites W1966916002 @default.
• W2988292303 cites W1967994686 @default.
• W2988292303 cites W1974494916 @default.
• W2988292303 cites W1975931490 @default.
• W2988292303 cites W1978094859 @default.
• W2988292303 cites W1985558623 @default.
• W2988292303 cites W1994500716 @default.
• W2988292303 cites W1998048927 @default.
• W2988292303 cites W2014771395 @default.
• W2988292303 cites W2015310734 @default.
• W2988292303 cites W2017045714 @default.
• W2988292303 cites W2021158172 @default.
• W2988292303 cites W2030194163 @default.
• W2988292303 cites W2033668318 @default.
• W2988292303 cites W2037380046 @default.
• W2988292303 cites W2038632547 @default.
• W2988292303 cites W2040392199 @default.
• W2988292303 cites W2041218370 @default.
• W2988292303 cites W2041999490 @default.
• W2988292303 cites W2045115362 @default.
• W2988292303 cites W2048143404 @default.
• W2988292303 cites W2052078062 @default.
• W2988292303 cites W2053900043 @default.
• W2988292303 cites W2055495862 @default.
• W2988292303 cites W2068494547 @default.
• W2988292303 cites W2069340283 @default.
• W2988292303 cites W2078387120 @default.
• W2988292303 cites W2086221877 @default.
• W2988292303 cites W2089401318 @default.
• W2988292303 cites W2091218020 @default.
• W2988292303 cites W2095520403 @default.
• W2988292303 cites W2104401164 @default.
• W2988292303 cites W2105099710 @default.
• W2988292303 cites W2105180873 @default.
• W2988292303 cites W2108909957 @default.
• W2988292303 cites W2111695773 @default.
• W2988292303 cites W2124096267 @default.
• W2988292303 cites W2126479592 @default.
• W2988292303 cites W2127782698 @default.
• W2988292303 cites W2128055407 @default.
• W2988292303 cites W2137021531 @default.
• W2988292303 cites W2137158234 @default.
• W2988292303 cites W2140341414 @default.
• W2988292303 cites W2147915752 @default.
• W2988292303 cites W2150178690 @default.
• W2988292303 cites W2152217218 @default.
• W2988292303 cites W2152885609 @default.
• W2988292303 cites W2153929491 @default.
• W2988292303 cites W2154539317 @default.
• W2988292303 cites W2158092720 @default.
• W2988292303 cites W2160979720 @default.
• W2988292303 cites W2161255301 @default.
• W2988292303 cites W2163228402 @default.
• W2988292303 cites W2166966371 @default.
• W2988292303 cites W2167008563 @default.
• W2988292303 cites W2168648059 @default.
• W2988292303 cites W2169169493 @default.
• W2988292303 cites W2171342498 @default.
• W2988292303 cites W2178266085 @default.
• W2988292303 cites W2255207203 @default.
• W2988292303 cites W2409239642 @default.
• W2988292303 cites W2619891302 @default.
• W2988292303 cites W2792056797 @default.
• W2988292303 cites W2884754721 @default.
• W2988292303 cites W2887452509 @default.
• W2988292303 cites W3022552886 @default.
• W2988292303 doi "https://doi.org/10.1016/j.jtbi.2019.110067" @default.
• W2988292303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31704311" @default.
• W2988292303 hasPublicationYear "2020" @default.
• W2988292303 type Work @default.
• W2988292303 sameAs 2988292303 @default.
• W2988292303 citedByCount "11" @default.
• W2988292303 countsByYear W29882923032019 @default.
• W2988292303 countsByYear W29882923032020 @default.
• W2988292303 countsByYear W29882923032021 @default.
• W2988292303 countsByYear W29882923032022 @default.
• W2988292303 countsByYear W29882923032023 @default.
• W2988292303 crossrefType "journal-article" @default.
• W2988292303 hasAuthorship W2988292303A5035781067 @default.
• W2988292303 hasAuthorship W2988292303A5041098720 @default.
• W2988292303 hasAuthorship W2988292303A5084570861 @default.
• W2988292303 hasBestOaLocation W29882923031 @default.
• W2988292303 hasConcept C121608353 @default.
• W2988292303 hasConcept C126322002 @default.

• next