FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2988294224> ?p ?o ?g. }

• W2988294224 abstract "Type 2 diabetes mellitus manifests in an insulin-resistant individual when pancreatic -cells are unable to produce sufficient insulin to overcome insulin resistance in the muscles and liver. There is a growing body of evidence that the thiazolidinedione (TZD) class of antidiabetic agents rejuvenates -cells and improves their function. When combination therapy with a sulfonylurea drug and metformin fails, treatment with a TZD increases C-peptide concentrations, reflecting improvement in -cell function. Further evidence of TZD-induced preservation of -cell function is documented by the findings of several recent trials in diabetes prevention. This apparent ability of TZDs to rejuvenate -cells, in addition to improving insulin resistance and glycemic control, is a compelling reason to use these agents as initial therapy for type 2 diabetes. Am J Med. 2003;115(8A): 20S–23S. © 2003 by Excerpta Medica, Inc. Type 2 diabetes mellitus occurs in an insulin-resistant individual when pancreatic -cells are unable to produce sufficient insulin to overcome insulin resistance in the muscles and liver. In the typical patient with type 2 diabetes, pancreatic decompensation begins more than a decade before diabetes is diagnosed (Figure 1). At this early stage, damage to the -cells is not caused by hyperglycemia, glycosylation of proteins, or amyloid deposition. Rather, it appears to occur because of lipotoxicity (i.e., elevated serum free fatty acids), which is also associated with the insulin resistance syndrome. An autopsy study in humans showed that fat content of -cells, but not -cells or duct cells, increased with age. Interestingly, only one third of insulin-resistant patients develop diabetes; in the other two thirds, insulin production and release increase to overcome the insulin resistance. In the one third of individuals who develop diabetes, pancreatic damage is thought to occur because of deposition of fat in the -cells; the latter is attributed to the inability of leptin to perform its physiologic function of protecting the -cell and other tissues from fat deposition. One theory suggests that with increased fat content of the -cell, there is an increase in free fatty acids and an increase in ceramide concentrations. This in turn stimulates expression of nitric oxide synthase, thereby increasing nitric oxide concentrations in the -cell and accelerating -cell apoptosis (Figure 2). In addition, free fatty acids may suppress the expression of the genes that are responsible for formation or replacement of -cells from stem cells in the pancreatic duct. However, a recent study showed that apoptosis, rather than decreased formation of -cells, is responsible for the reduction in -cell mass. Therefore, the lowering of tissue triglyceride content that occurs with use of the thiazolidinediones (TZDs) should result in decreased -cell apoptosis and increased formation of new -cells, leading to an increase in -cell mass and endogenous insulin production. This article will focus on data evaluating the effects of TZDs on -cell rejuvenation." @default.
• W2988294224 created "2019-11-22" @default.
• W2988294224 creator A5090691654 @default.
• W2988294224 date "2003-01-01" @default.
• W2988294224 modified "2023-09-26" @default.
• W2988294224 title "Cell Rejuvenation with Thiazolidinediones" @default.
• W2988294224 cites W1968237817 @default.
• W2988294224 cites W1971269545 @default.
• W2988294224 cites W2016247822 @default.
• W2988294224 cites W2017604923 @default.
• W2988294224 cites W2043209055 @default.
• W2988294224 cites W2072031497 @default.
• W2988294224 cites W2077149049 @default.
• W2988294224 cites W2080153104 @default.
• W2988294224 cites W2091035564 @default.
• W2988294224 cites W2100514340 @default.
• W2988294224 cites W2106080706 @default.
• W2988294224 cites W2113544353 @default.
• W2988294224 cites W2132594773 @default.
• W2988294224 cites W2166232000 @default.
• W2988294224 cites W1991131043 @default.
• W2988294224 hasPublicationYear "2003" @default.
• W2988294224 type Work @default.
• W2988294224 sameAs 2988294224 @default.
• W2988294224 citedByCount "2" @default.
• W2988294224 countsByYear W29882942242012 @default.
• W2988294224 crossrefType "journal-article" @default.
• W2988294224 hasAuthorship W2988294224A5090691654 @default.
• W2988294224 hasConcept C126322002 @default.
• W2988294224 hasConcept C134018914 @default.
• W2988294224 hasConcept C2776923340 @default.
• W2988294224 hasConcept C2777180221 @default.
• W2988294224 hasConcept C2777391703 @default.
• W2988294224 hasConcept C2777448766 @default.
• W2988294224 hasConcept C2778854520 @default.
• W2988294224 hasConcept C2779306644 @default.
• W2988294224 hasConcept C2780323712 @default.
• W2988294224 hasConcept C2910068830 @default.
• W2988294224 hasConcept C44353895 @default.
• W2988294224 hasConcept C555293320 @default.
• W2988294224 hasConcept C71924100 @default.
• W2988294224 hasConceptScore W2988294224C126322002 @default.
• W2988294224 hasConceptScore W2988294224C134018914 @default.
• W2988294224 hasConceptScore W2988294224C2776923340 @default.
• W2988294224 hasConceptScore W2988294224C2777180221 @default.
• W2988294224 hasConceptScore W2988294224C2777391703 @default.
• W2988294224 hasConceptScore W2988294224C2777448766 @default.
• W2988294224 hasConceptScore W2988294224C2778854520 @default.
• W2988294224 hasConceptScore W2988294224C2779306644 @default.
• W2988294224 hasConceptScore W2988294224C2780323712 @default.
• W2988294224 hasConceptScore W2988294224C2910068830 @default.
• W2988294224 hasConceptScore W2988294224C44353895 @default.
• W2988294224 hasConceptScore W2988294224C555293320 @default.
• W2988294224 hasConceptScore W2988294224C71924100 @default.
• W2988294224 hasLocation W29882942241 @default.
• W2988294224 hasOpenAccess W2988294224 @default.
• W2988294224 hasPrimaryLocation W29882942241 @default.
• W2988294224 hasRelatedWork W1548248963 @default.
• W2988294224 hasRelatedWork W16308079 @default.
• W2988294224 hasRelatedWork W2034208622 @default.
• W2988294224 hasRelatedWork W2043770389 @default.
• W2988294224 hasRelatedWork W2058661481 @default.
• W2988294224 hasRelatedWork W2059253812 @default.
• W2988294224 hasRelatedWork W2067943472 @default.
• W2988294224 hasRelatedWork W2095096269 @default.
• W2988294224 hasRelatedWork W2111597050 @default.
• W2988294224 hasRelatedWork W2169835146 @default.
• W2988294224 hasRelatedWork W2184857457 @default.
• W2988294224 hasRelatedWork W2414284935 @default.
• W2988294224 hasRelatedWork W2414818470 @default.
• W2988294224 hasRelatedWork W2417373749 @default.
• W2988294224 hasRelatedWork W2480759272 @default.
• W2988294224 hasRelatedWork W2760388466 @default.
• W2988294224 hasRelatedWork W2887550150 @default.
• W2988294224 hasRelatedWork W3010447564 @default.
• W2988294224 hasRelatedWork W3149272308 @default.
• W2988294224 hasRelatedWork W2902192930 @default.
• W2988294224 isParatext "false" @default.
• W2988294224 isRetracted "false" @default.
• W2988294224 magId "2988294224" @default.
• W2988294224 workType "article" @default.