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• W2988403040 abstract "Abstract Background Successful establishment of pregnancy hinges on appropriate communication between the embryo and the uterus prior to implantation, but the nature of this communication remains poorly understood. Here, we tested the hypothesis that the endometrium is receptive to embryo-derived signals in the form of RNA. Methods We have utilized a non-contact co culture system to simulate the conditions of pre implantation environment of the uterus. We bioorthogonally tagged embryonic RNA and tracked the transferred transcripts to endometrium. Transferred transcripts were separated from endometrial transcripts and sequenced. Changes in endometrial transcripts were quantified using quantitative PCR. Results We show that three specific transcripts are transferred to endometrial cells. We subsequently demonstrate a role of extracellular vesicles (EVs) in this process, as EVs obtained from cultured trophoblast spheroids incubated with endometrial cells induced down-regulation of all the three identified transcripts in endometrial cells. Finally, we show that EVs/nanoparticles captured from conditioned culture media of viable embryos as opposed to degenerating embryos induce ZNF81 down-regulation in endometrial cells, hinting at the functional importance of this intercellular communication. Conclusion Ultimately, our findings demonstrate the existence of an RNA-based communication which may be of critical importance for the establishment of pregnancy." @default.
• W2988403040 created "2019-11-22" @default.
• W2988403040 creator A5001474940 @default.
• W2988403040 creator A5023716499 @default.
• W2988403040 creator A5037239931 @default.
• W2988403040 creator A5039603721 @default.
• W2988403040 creator A5048094466 @default.
• W2988403040 creator A5049113871 @default.
• W2988403040 creator A5056642994 @default.
• W2988403040 creator A5057082982 @default.
• W2988403040 creator A5061962903 @default.
• W2988403040 creator A5067620941 @default.
• W2988403040 creator A5071051674 @default.
• W2988403040 creator A5083430240 @default.
• W2988403040 date "2019-11-14" @default.
• W2988403040 modified "2023-10-10" @default.
• W2988403040 title "Specific trophoblast transcripts transferred by extracellular vesicles affect gene expression in endometrial epithelial cells and may have a role in embryo-maternal crosstalk" @default.
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• W2988403040 doi "https://doi.org/10.1186/s12964-019-0448-x" @default.

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